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N-[3-(2-呋喃基)丙烯酰]-L-苯丙氨酰-甘氨酰-甘氨酸

用途

N-[3-(2-呋喃)丙烯酰基]-Phe-Gly-Gly(FAPGG)是用于血管紧张素转换酶(ACE)测定的合成色甘酸底物[1]。

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名称

[ CAS 号 ]:
64967-39-1

[ 中文名 ]:
N-[3-(2-呋喃基)丙烯酰]-L-苯丙氨酰-甘氨酰-甘氨酸

[ 英文名 ]:
FA-Phe-Gly-Gly-OH

[中文别名 ]:

[英文别名 ]:

FAPGG

生物活性

[ 描述 ]:

N-[3-(2-呋喃)丙烯酰基]-Phe-Gly-Gly(FAPGG)是用于血管紧张素转换酶(ACE)测定的合成色甘酸底物[1]。

[ 相关类别 ]:

研究领域 >> 其他

信号通路 >> 代谢酶/蛋白酶 >> 血管紧张素转换酶(ACE)

[参考文献]

[1]. Hsu FL, et al. Both dioscorin, the tuber storage protein of yam (Dioscorea alata cv. Tainong No. 1), and its peptic hydrolysates exhibited angiotensin converting enzyme inhibitory activities. J Agric Food Chem. 2002 Oct 9;50(21):6109-13.

物理化学性质

[ 密度 ]:
1.3±0.1 g/cm3

[ 沸点 ]:
842.3±65.0 °C at 760 mmHg

[ 熔点 ]:
245ºC (dec.)(lit.)

[ 分子式 ]:
C₂₀H₂₁N₃O₆

[ 分子量 ]:
399.397

[ 闪点 ]:
463.2±34.3 °C

[ 精确质量 ]:
399.143036

[ PSA ]:
137.74000

[ LogP ]:
1.77

[ 外观性状 ]:
灰白色至淡黄褐色的粉末

[ 蒸汽压 ]:
0.0±3.3 mmHg at 25°C

[ 折射率 ]:
1.603

[ 储存条件 ]:
−20°C

[ 水溶解性 ]:
NH4OH 1 M: 50 mg/mL, clear to slightly turbid, yellow

安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危害码 (欧洲) ]:
Xi: Irritant;

[ 风险声明 (欧洲) ]:
R36/37/38

[ 安全声明 (欧洲) ]:
22-24/25

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ RTECS号 ]:
OH2915000

[ 海关编码 ]:
29321900

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文献

Effect of power ultrasound pretreatment on peptidic profiles and angiotensin converting enzyme inhibition of milk protein concentrate hydrolysates.

J. Sci. Food Agric. 94(12) , 2420-8, (2014)

The use of power ultrasound as a pretreatment to enhance the hydrolysis of milk protein concentrate (MPC) and subsequent angiotensin converting enzyme (ACE) inhibitory activity has been studied. Liqui...

Assessment and optimization of kinetic methods for angiotensin-converting enzyme in plasma.

Clin. Chem. 39(2) , 312-6, (1993)

In the kinetic angiotensin-converting enzyme (ACE) method, a practical and optimal buffer is 80 mmol/L borate buffer at pH 8.2 (37 degrees C). A lag phase is detected in the reaction, and a 5-min incu...

Evidence for the negative cooperativity of the two active sites within bovine somatic angiotensin-converting enzyme.

FEBS Lett. 550(1-3) , 84-8, (2003)

The somatic isoform of angiotensin-converting enzyme (ACE) consists of two homologous domains (N- and C-domains), each bearing a catalytic site. We have used the two-domain ACE form and its individual...

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