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3,6-二氧杂-1,8-辛二胺四乙酸(EGTA)

3,6-二氧杂-1,8-辛二胺四乙酸(EGTA)用途

EGTA 是一种特殊的钙离子螯合剂。EGTA 在生理 pH 值 (7.4) 下,Kd 为 60.5 nM,对 Ca2+ 比对 Mg2+ 有很高的特异性。EGTA 显著抑制炎性巨噬细胞的底物粘附能力。

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3,6-二氧杂-1,8-辛二胺四乙酸(EGTA)名称

[ CAS 号 ]:
67-42-5

[ 中文名 ]:
乙二醇双(2-氨基乙基醚)四乙酸

[ 英文名 ]:
EGTA

[中文别名 ]:

[英文别名 ]:

Egtazic acid
Egtazic
4F 4PP oxalate
CHEL-DE
EGTA
AEGT
ethylene glycol bis(2-aminoethyl)tetraacetic acid
(Ethylenebis(oxyethylenenitrilo))tetraacetic acid
EINECS 200-651-2
Ethylenebis(oxyethylenenitrilo)tetraacetic acid

3,6-二氧杂-1,8-辛二胺四乙酸(EGTA)生物活性

[ 描述 ]:

EGTA 是一种特殊的钙离子螯合剂。EGTA 在生理 pH 值 (7.4) 下,Kd 为 60.5 nM,对 Ca2+ 比对 Mg2+ 有很高的特异性。EGTA 显著抑制炎性巨噬细胞的底物粘附能力。

[ 相关类别 ]:

信号通路 >> 其他 >> 其他

研究领域 >> 炎症/免疫

[体外研究]

以剂量依赖性的方式,依时间和剂量减少巨噬细胞粘附。引起IC50的EGTA浓度为202 mM。螯合剂与羟基磷灰石晶体中的钙离子反应生成金属螯合物。去除牙本质中的钙离子会使牙本质组织变软,尤其是富含羟基磷灰石的管周牙本质,并增加暴露的牙本质小管的直径[2]。

[参考文献]

[1]. Harris RA, Hanrahan JW. Effects of EGTA on calcium signaling in airway epithelial cells. Am J Physiol. 1994;267(5 Pt 1):C1426-C1434. doi:10.1152/ajpcell.1994.267.5.C1426

[2]. Segura-Egea JJ, Jiménez-Rubio A, Rios-Santos JV, Velasco-Ortega E, Calvo-Gutierrez JR. In vitro inhibitory effect of EGTA on macrophage adhesion: endodontic implications. J Endod. 2003;29(3):211-213.

3,6-二氧杂-1,8-辛二胺四乙酸(EGTA)物理化学性质

[ 密度 ]:
1.4±0.1 g/cm3

[ 沸点 ]:
678.0±55.0 °C at 760 mmHg

[ 熔点 ]:
241 °C (dec.)(lit.)

[ 分子式 ]:
C₁₄H₂₄N₂O₁₀

[ 分子量 ]:
380.348

[ 闪点 ]:
363.9±31.5 °C

[ 精确质量 ]:
380.143097

[ PSA ]:
174.14000

[ LogP ]:
-2.53

[ 外观性状 ]:
白色粉末

[ 蒸汽压 ]:
0.0±4.5 mmHg at 25°C

[ 折射率 ]:
1.547

[ 储存条件 ]:
Store at RT.

[ 水溶解性 ]:
slightly soluble

3,6-二氧杂-1,8-辛二胺四乙酸(EGTA)MSDS

3,6-二氧杂-1,8-辛二胺四乙酸(EGTA)毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: AH3760000

CHEMICAL NAME :: Acetic acid, (ethylenebis(oxyethylenenitrilo))tetra-

CAS REGISTRY NUMBER :: 67-42-5

BEILSTEIN REFERENCE NO. :: 1717370

LAST UPDATED :: 199701

DATA ITEMS CITED :: 5

MOLECULAR FORMULA :: C14-H24-N2-O10

MOLECULAR WEIGHT :: 380.40

WISWESSER LINE NOTATION :: QV1N1VQ2O2O2N1VQ1VQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 3587 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 16,807,1970

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 150 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: AD691-490 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 84753 No. of Facilities: 111 (estimated) No. of Industries: 1 No. of Occupations: 3 No. of Employees: 664 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 84753 No. of Facilities: 103 (estimated) No. of Industries: 1 No. of Occupations: 4 No. of Employees: 1556 (estimated) No. of Female Employees: 1043 (estimated)

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3,6-二氧杂-1,8-辛二胺四乙酸(EGTA)安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危害码 (欧洲) ]:
Xi

[ 风险声明 (欧洲) ]:
R36/37/38

[ 安全声明 (欧洲) ]:
S24/25

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
2

[ RTECS号 ]:
AH3760000

[ 海关编码 ]:
29225000

3,6-二氧杂-1,8-辛二胺四乙酸(EGTA)合成路线

3,6-二氧杂-1,8-辛二胺四乙酸(EGTA)上下游产品

3,6-二氧杂-1,8-辛二胺四乙酸(EGTA)上游产品

3,6-二氧杂-1,8-辛二胺四乙酸(EGTA)下游产品

3,6-二氧杂-1,8-辛二胺四乙酸(EGTA)海关

[ 海关编码 ]: 29225000

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