DL-甲瓦龙酸内酯

DL-甲瓦龙酸内酯用途

DL-Mevalonolactone ((±) -Mevalonolactone; Mevalolactone) 是甲羟戊酸的 δ-lactone 形式,甲羟戊酸途径的一个前体。DL-Mevalonolactone (Mevalonolactone) 可以降低大脑中线粒体膜电位 (∆Ψm),NAD (P) H 的含量和 Ca2+ 的保留能力, 而且还诱导线粒体肿胀。

点击显示

DL-甲瓦龙酸内酯名称

[ CAS 号 ]:
674-26-0

[ 中文名 ]:
甲瓦龙酸内酯

[ 英文名 ]:
DL-Mevalonolactone

[中文别名 ]:

[英文别名 ]:

(3RS)-mevalonolactone
MEVALONIC LACTONE
(+/-)-MEVALONOLACTONE
EINECS 211-615-0
DL-MEVALOLACTONE
MFCD00006648
DL-mevalonic acid lactone
D,L-MEVELONIC ACID LACTONE
MEVALONIC ACID LACTONE,DL
(RS)-mevalonolactone

DL-甲瓦龙酸内酯生物活性

[ 描述 ]:

[ 相关类别 ]:

信号通路 >> 其他 >> 其他

研究领域 >> 代谢疾病

[参考文献]

[1]. Domingos SR, et al. On the structural intricacies of a metabolic precursor: Direct spectroscopic detection of water-induced conformational reshaping of mevalonolactone. J Chem Phys. 2017 Sep 28;147(12):124310.

[2]. Cecatto C, et al. Mevalonolactone disrupts mitochondrial functions and induces permeability transition pore opening in rat brain mitochondria: Implications for the pathogenesis of mevalonic aciduria. Neurochem Int. 2017 Sep;108:133-145.

DL-甲瓦龙酸内酯物理化学性质

[ 密度 ]:
1.189 g/cm3

[ 沸点 ]:
145-150 °C5 mm Hg(lit.)

[ 熔点 ]:
28 °C(lit.)

[ 分子式 ]:
C₆H₁₀O₃

[ 分子量 ]:
130.14200

[ 闪点 ]:
>230 °F

[ 精确质量 ]:
130.06300

[ PSA ]:
46.53000

[ LogP ]:
0.07440

[ 外观性状 ]:
潮湿的淡黄色至灰白色固体

[ 折射率 ]:
n20/D 1.473(lit.)

[ 储存条件 ]:
2-8°C

[ 稳定性 ]:
Hygroscopic

DL-甲瓦龙酸内酯MSDS

DL-甲瓦龙酸内酯安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ 海关编码 ]:
2932999099

DL-甲瓦龙酸内酯合成路线

DL-甲瓦龙酸内酯上下游产品

DL-甲瓦龙酸内酯上游产品

DL-甲瓦龙酸内酯下游产品

DL-甲瓦龙酸内酯海关

[ 海关编码 ]: 2932999099

[ 中文概述 ]:
2932999099. 其他仅含氧杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2932999099. other heterocyclic compounds with oxygen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

DL-甲瓦龙酸内酯文献

In vitro and in vivo anticancer effects of mevalonate pathway modulation on human cancer cells.

Br. J. Cancer 111(8) , 1562-71, (2014)

The increasing usage of statins (the 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors) has revealed a number of unexpected beneficial effects, including a reduction in cancer risk.We investi...

Synthesis and HMG-CoA reductase inhibition of 2-cyclopropyl-4-thiophenyl-quinoline mevalonolactones.

Bioorg. Med. Chem. 17(23) , 7915-23, (2009)

A novel series of 2-cyclopropyl-4-thiophenyl quinoline-based mevalonolactones were synthesized from the substituted anilines by several reactions. Among them, (4R,6S)-6-[(E)-2-(2-cyclopropyl-6-fluoro-...

Highly sensitive assay of HMG-CoA reductase activity by LC-ESI-MS/MS.

J. Lipid Res. 48(5) , 1212-20, (2007)

We have developed a new sensitive and specific nonradioisotope assay method to measure the activity of HMG-CoA reductase, the rate-controlling enzyme in the cholesterol biosynthetic pathway. This meth...

更多文献