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美格鲁托

美格鲁托用途

Meglutol是一种抗血脂剂, 降低胆固醇, 甘油三酯, 及血清β-脂蛋白和磷脂, 并抑制羟甲基戊二酰辅酶A还原酶活性, 这是在胆固醇生物合成中的限速酶。

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美格鲁托名称

[ CAS 号 ]:
503-49-1

[ 中文名 ]:
3-羟基-3-甲基谷氨酸

[ 英文名 ]:
3-hydroxy-3-methylglutaric acid

[中文别名 ]:

[英文别名 ]:

EINECS 207-971-1
MFCD00002712
3-hydroxy-3-methylpentanedioic acid
3-Hydroxy-3-Methylglutaric Acid
Meglutol

美格鲁托生物活性

[ 描述 ]:

Meglutol是一种抗血脂剂, 降低胆固醇, 甘油三酯, 及血清β-脂蛋白和磷脂, 并抑制羟甲基戊二酰辅酶A还原酶活性, 这是在胆固醇生物合成中的限速酶。

[ 相关类别 ]:

信号通路 >> 代谢酶/蛋白酶 >> HMG-CoA还原酶(HMGCR)

研究领域 >> 心血管疾病

[相关活性小分子]

美格鲁托物理化学性质

[ 密度 ]:
1.417 g/cm3

[ 沸点 ]:
120 °C / 13mmHg

[ 熔点 ]:
105-108 °C(lit.)

[ 分子式 ]:
C₆H₁₀O₅

[ 分子量 ]:
162.14100

[ 闪点 ]:
182.2ºC

[ 精确质量 ]:
162.05300

[ PSA ]:
94.83000

[ 外观性状 ]:
灰白色粉末带有大块

[ 折射率 ]:
1.512

[ 储存条件 ]:
−20°C

美格鲁托MSDS

美格鲁托毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: MA3753000

CHEMICAL NAME :: Glutaric acid, 3-hydroxy-3-methyl-

CAS REGISTRY NUMBER :: 503-49-1

BEILSTEIN REFERENCE NO. :: 1769194

LAST UPDATED :: 199612

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C6-H10-O5

MOLECULAR WEIGHT :: 162.16

WISWESSER LINE NOTATION :: QV1XQ1&1VQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 7330 mg/kg

TOXIC EFFECTS :: Brain and Coverings - recordings from specific areas of CNS Behavioral - somnolence (general depressed activity) Lungs, Thorax, or Respiration - other changes

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 25,1284,1975

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 3230 mg/kg

TOXIC EFFECTS :: Brain and Coverings - recordings from specific areas of CNS Behavioral - somnolence (general depressed activity) Lungs, Thorax, or Respiration - other changes

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 25,1284,1975

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美格鲁托安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危害码 (欧洲) ]:
Xi

[ 风险声明 (欧洲) ]:
36/37/38

[ 安全声明 (欧洲) ]:
S22-S24/25

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
2

[ RTECS号 ]:
MA3753000

[ 海关编码 ]:
2918199090

美格鲁托合成路线

美格鲁托上下游产品

美格鲁托上游产品

美格鲁托下游产品

美格鲁托海关

[ 海关编码 ]: 2918199090

[ 中文概述 ]:
HS: 2918199090. 其他含醇基但不含其他含氧基羧酸（包括其酸酐、酰卤化物、过氧化物和过氧酸及该税号的衍生物）. 增值税率:17.0%. 退税率:9.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2918199090 other carboxylic acids with alcohol function but without other oxygen function, their anhydrides, halides, peroxides, peroxyacids and their derivatives。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:30.0%

美格鲁托文献

NMR spectroscopic studies on the late onset form of 3-methylglutaconic aciduria type I and other defects in leucine metabolism.

NMR Biomed. 19(2) , 271-8, (2006)

A diagnosis of 3-methylglutaconic aciduria type I (OMIM: 250950) based on elevated urinary excretion of 3-methylglutaconic acid (3MGA), 3-methylglutaric acid (3MG) and 3-hydroxyisovaleric acid (3HIVA)...

Unimolecular reaction chemistry of a charge-tagged beta-hydroxyperoxyl radical.

Phys. Chem. Chem. Phys. 16(45) , 24954-64, (2014)

β-Hydroxyperoxyl radicals are formed during atmospheric oxidation of unsaturated volatile organic compounds such as isoprene. They are intermediates in the combustion of alcohols. In these environment...

Mitochondrial DNA depletion associated with partial complex II and IV deficiencies and 3-methylglutaconic aciduria.

J. Child Neurol. 16(2) , 136-8, (2001)

We report a patient with mitochondrial DNA depletion, partial complex II and IV deficiencies, and 3-methylglutaconic aciduria. Complex II deficiency has not been previously observed in mitochondrial D...

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