1-β-d-ARABINOFURANOSYL-2′,3′,5′-TRIACETATE
名称
[ CAS 号 ]:
6742-07-0
[ 英文名 ]:
1-β-d-ARABINOFURANOSYL-2′,3′,5′-TRIACETATE
[英文别名 ]:
- triacetylcytarabine
- 2',3',5'-tri-O-acetyl-arabinofuranosyl-cytidine
- AraC 2',3',5'-tri-O-acetyl ester
物理化学性质
[ 密度 ]:
1.52g/cm3
[ 沸点 ]:
507.4ºC at 760 mmHg
[ 分子式 ]:
C15H19N3O8
[ 分子量 ]:
369.32700
[ 闪点 ]:
260.6ºC
[ 精确质量 ]:
369.11700
[ PSA ]:
149.04000
[ 折射率 ]:
1.61
毒性和生态
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- HA5600000
- CHEMICAL NAME :
- Cytosine, 1-beta-D-arabino-furanosyl-, 2',3',5'-triacetate
- CAS REGISTRY NUMBER :
- 6742-07-0
- LAST UPDATED :
- 199606
- DATA ITEMS CITED :
- 8
- MOLECULAR FORMULA :
- C15-H19-N3-O8
- MOLECULAR WEIGHT :
- 369.37
- WISWESSER LINE NOTATION :
- T6NVNJ DZ A- BT5OTJ COV1 DOV1 E1OV1
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- >5010 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 4400 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 680 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 1 gm/kg/5D-I
- TOXIC EFFECTS :
- Related to Chronic Data - death
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Mammal - dog
- DOSE/DURATION :
- 750 mg/kg/15D-I
- TOXIC EFFECTS :
- Gastrointestinal - hypermotility, diarrhea Blood - changes in bone marrow (not otherwise specified) Nutritional and Gross Metabolic - body temperature increase
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Primate - monkey
- DOSE/DURATION :
- 3 gm/kg/15D-I
- TOXIC EFFECTS :
- Kidney, Ureter, Bladder - changes primarily in glomeruli Blood - thrombocytopenia Related to Chronic Data - death
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Primate - monkey
- DOSE/DURATION :
- 750 mg/kg/15D-I
- TOXIC EFFECTS :
- Gastrointestinal - nausea or vomiting Nutritional and Gross Metabolic - weight loss or decreased weight gain Related to Chronic Data - death
MUTATION DATA
- TYPE OF TEST :
- DNA inhibition
- TEST SYSTEM :
- Rodent - mouse Leukocyte
- DOSE/DURATION :
- 49 umol/L
- REFERENCE :
- CCCCAK Collection of Czechoslovak Chemical Communications. (Academic Press Inc. Ltd., 24-28 Oval Rd., London NW1 7DX, UK) V.1- 1929- Volume(issue)/page/year: 49,2551,1984
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