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2,2'-脱水尿苷

2,2'-脱水尿苷用途

2,2'-Anhydrouridine 可以用于抗肿瘤和抗病毒研究[1]。

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2,2'-脱水尿苷名称

[ CAS 号 ]:
3736-77-4

[ 中文名 ]:
2,2'-脱水尿苷

[ 英文名 ]:
2,2'-Cyclouridine

[中文别名 ]:

[英文别名 ]:

O2,2'-Cyclouridine
EINECS 223-107-6
2,2'-Cyclouridine
2,2'-O-Cyclouridine
MFCD00004945
2,2-Anhydro-1(b-D-arabinofuranosyl)uracil
2,2'-Anhydro-1(B-D-arabinofuranosyl)uracil
2,2′-O-Cyclouridine
O2,2'-Cyclouridine (VAN)
2,2'-Anhydrouridine

2,2'-脱水尿苷生物活性

[ 描述 ]:

2,2'-Anhydrouridine 可以用于抗肿瘤和抗病毒研究[1]。

[ 相关类别 ]:

信号通路 >> 其他 >> 其他

研究领域 >> 癌症

研究领域 >> 感染

[参考文献]

[1]. Drabikowska AK, et al. Inhibitor properties of some 5-substituted uracil acyclonucleosides, and 2,2'-anhydrouridines versus uridine phosphorylase from E. coli and mammalian sources. Biochem Pharmacol. 1987 Dec 1;36(23):4125-8.

[相关活性小分子]

2,2'-脱水尿苷物理化学性质

[ 密度 ]:
2.0±0.1 g/cm3

[ 沸点 ]:
456.3±55.0 °C at 760 mmHg

[ 熔点 ]:
239-240ºC

[ 分子式 ]:
C₉H₁₀N₂O₅

[ 分子量 ]:
226.186

[ 闪点 ]:
229.8±31.5 °C

[ 精确质量 ]:
226.058975

[ PSA ]:
93.81000

[ LogP ]:
-1.40

[ 外观性状 ]:
固体;White to Almost white powder to crystal

[ 蒸汽压 ]:
0.0±2.5 mmHg at 25°C

[ 折射率 ]:
1.816

[ 储存条件 ]:
Store at RT.

2,2'-脱水尿苷MSDS

2,2'-脱水尿苷安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危害码 (欧洲) ]:
T+

[ 安全声明 (欧洲) ]:
24/25

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ 海关编码 ]:
29349990

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2,2'-脱水尿苷文献

2,2'-Anhydro-1-(3',5'-di-O-acetyl-β-D-arabinofuranosyl)uracil, a cyclouridine nucleoside with a C4'-endo furanosyl conformation.

Acta Crystallogr. C 69(Pt 3) , 282-4, (2013)

2,2'-Anhydro-1-(3',5'-di-O-acetyl-β-D-arabinofuranosyl)uracil, C13H14N2O7, was obtained by refluxing 2',3'-O-(methoxymethylene)uridine in acetic anhydride. The structure exhibits a nearly perfect C4'-...

Aldrichimica Acta 20 , 52, (1987)

Inhibitor properties of some 5-substituted uracil acyclonucleosides, and 2,2'-anhydrouridines versus uridine phosphorylase from E. coli and mammalian sources.

Biochem. Pharmacol. 36(23) , 4125-8, (1987)

Two series of 5-substituted uracil N(1)-acyclonucleosides, each with a different acyclic chain, were examined as inhibitors of uridine phosphorylase from rat intestinal mucosa, and several against the...

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