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蓼二醛

蓼二醛用途

Polygodial(Poligodial)是一种抗真菌增强剂[1]。聚二醇是一种具有抗痛觉过敏特性的倍半萜[2]。

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蓼二醛名称

[ CAS 号 ]:
6754-20-7

[ 中文名 ]:
水蓼二醛

[ 英文名 ]:
(-)-Polygodial

[英文别名 ]:

UNII:A00RAV0W57
Podofilox
Wartec
Condylox
Podophyllotoxin 7
Condyline
S-Isopropylisothiourea hydrobromide
Polygodial
Warticon
Podophyllinic acid lactone

蓼二醛生物活性

[ 描述 ]:

Polygodial(Poligodial)是一种抗真菌增强剂[1]。聚二醇是一种具有抗痛觉过敏特性的倍半萜[2]。

[ 相关类别 ]:

研究领域 >> 感染

信号通路 >> 抗感染 >> 真菌

研究领域 >> 炎症/免疫

[体外研究]

在标准化敏感性试验(NCCLS)中,Polygodial对酿酒酵母、白色念珠菌和其他真菌病原体具有杀菌活性。在RPMI 1640培养基中,与最低杀菌浓度(MFC)为106 CFU/mL的酿酒酵母细胞中的对照组相比,聚乙二醇(12.5μg/mL,3小时)诱导显著收缩[3]。细胞活力测定[3]细胞系：S。酿酒酵母细胞浓度：12.5μg/mL孵育时间：3小时结果：与对照组相比,处理后的细胞显示出显著的收缩,亚细胞器的组织被破坏或致密。

[体内研究]

聚二醛是一种倍半萜,从冬石楠树皮(冬科)中分离得到。聚乙二醇(0.5至10 mg/kg；0.5小时；通过腹腔注射给小鼠)诱导显著、剂量相关且几乎完全抑制醋酸、高岭土和酵母多糖诱导的腹部收缩。计算的平均ID50值分别为0.8、2.1和2.6 mg/kg,对醋酸、高岭土和酵母多糖的最大抑制率分别为90.0±3.0、98.0±1.0和97.0±2.0%。在ID50水平下,Polygodial的效力约为水醇提取物(HE)的14-27倍[2]。动物模型：未禁食的雄性瑞士小鼠(20-30 g)或雄性Wistar大鼠(150-180 g)[2]剂量：0.1至10 mg/kg给药：在注射刺激性物质前0.5 h腹腔注射结果：对醋酸、高岭土和酵母多糖诱导的小鼠扭体产生显著抑制作用。

[参考文献]

[1]. I Kubo, et al. Polygodial, an antifungal potentiator. J Nat Prod. Jan-Feb 1988;51(1):22-9.

[2]. G L Mendes, et al. Anti-hyperalgesic properties of the extract and of the main sesquiterpene polygodial isolated from the barks of Drymis winteri (Winteraceae). Life Sci. 1998;63(5):369-81.

[3]. C S Lunde, et al. Effect of polygodial on the mitochondrial ATPase of Saccharomyces cerevisiae. Antimicrob Agents Chemother. 2000 Jul;44(7):1943-53.

蓼二醛物理化学性质

[ 密度 ]:
1.1±0.1 g/cm3

[ 沸点 ]:
330.7±35.0 °C at 760 mmHg

[ 分子式 ]:
C₁₅H₂₂O₂

[ 分子量 ]:
234.334

[ 闪点 ]:
124.0±22.9 °C

[ 精确质量 ]:
234.161987

[ PSA ]:
34.14000

[ LogP ]:
3.84

[ 外观性状 ]:
固体

[ 蒸汽压 ]:
0.0±0.7 mmHg at 25°C

[ 折射率 ]:
1.570

[ 储存条件 ]:
20°C

蓼二醛安全信息

[ 危害码 (欧洲) ]:
Xn

[ 风险声明 (欧洲) ]:
52/53

[ 危险品运输编码 ]:
NONH for all modes of transport

[ RTECS号 ]:
QJ2850000

蓼二醛文献

Screening for negative effects of candidate ascidian antifoulant compounds on a target aquaculture species, Perna canaliculus Gmelin.

Biofouling 29(1) , 29-37, (2013)

The natural chemical compounds radicicol, polygodial and ubiquinone-10 (Q10) have previously been identified as inhibitors of metamorphosis in ascidian larvae. Accordingly, they have potential as a sp...

Preventing ascidian fouling in aquaculture: screening selected allelochemicals for anti-metamorphic properties in ascidian larvae.

Biofouling 28(1) , 39-49, (2012)

Fouling by ascidians causes major stock losses and disrupts production in marine aquaculture, especially bivalve aquaculture. Currently, no cost effective solution exists despite the testing of many p...

Inhibition of the mitochondrial ATP synthesis by polygodial, a naturally occurring dialdehyde unsaturated sesquiterpene.

Biochem. Pharmacol. 70(1) , 82-9, (2005)

Polygodial is a naturally occurring sesquiterpene dialdehyde that exhibits several pharmacologically interesting activities. Among them, its antifungal properties have been more thoroughly studied. Th...

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蓼二醛