阿非昔芬

阿非昔芬用途

(E/Z)-4-Hydroxytamoxifen 是 (Z)-4-Hydroxytamoxifen 和 (E)-4-Hydroxytamoxifen 的消旋体。(E/Z)-4-Hydroxytamoxifen 是雌激素受体 (estrogen receptor) 调节剂。

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阿非昔芬名称

[ CAS 号 ]:
68392-35-8

[ 中文名 ]:
4-羟基他莫西芬

[ 英文名 ]:
(E/Z)-4-hydroxy Tamoxifen

[中文别名 ]:

阿非昔芬

[英文别名 ]:

4-hydroxytamoxifene
(E,Z)-4-hydroxytamoxifen

阿非昔芬生物活性

[ 描述 ]:

(E/Z)-4-Hydroxytamoxifen 是 (Z)-4-Hydroxytamoxifen 和 (E)-4-Hydroxytamoxifen 的消旋体。(E/Z)-4-Hydroxytamoxifen 是雌激素受体 (estrogen receptor) 调节剂。

[ 相关类别 ]:

信号通路 >> 其他 >> 雌激素受体/ERR

研究领域 >> 癌症

[ 靶点 ]

Estrogen receptor

阿非昔芬物理化学性质

[ 密度 ]:
1.092

[ 熔点 ]:
135-144°C

[ 分子式 ]:
C₂₆H₂₉NO₂

[ 分子量 ]:
387.51400

[ 精确质量 ]:
387.22000

[ PSA ]:
32.70000

[ LogP ]:
5.70170

[ 外观性状 ]:
white to off-white

[ 储存条件 ]:
Refrigerator

[ 水溶解性 ]:
methanol: soluble10mg/mL

阿非昔芬MSDS

详细MSDS(安全技术说明书)

阿非昔芬安全信息

[ 符号 ]:

GHS07, GHS08

[ 信号词 ]:
Warning

[ 危害声明 ]:
H302-H312-H332-H361

[ 警示性声明 ]:
P280

[ 个人防护装备 ]:
Eyeshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges

[ 危害码 (欧洲) ]:
Xn

[ 风险声明 (欧洲) ]:
63-20/21/22

[ 安全声明 (欧洲) ]:
22-23-36

[ 危险品运输编码 ]:
NONH for all modes of transport

[ RTECS号 ]:
SL1210000

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阿非昔芬文献

Combined histone deacetylase inhibition and tamoxifen induces apoptosis in tamoxifen-resistant breast cancer models, by reversing Bcl-2 overexpression.

Breast Cancer Res. 17 , 26, (2015)

The emergence of hormone therapy resistance, despite continued expression of the estrogen receptor (ER), is a major challenge to curing breast cancer. Recent clinical studies suggest that epigenetic m...

Selective inhibition of RET mediated cell proliferation in vitro by the kinase inhibitor SPP86.

BMC Cancer 14 , 853, (2014)

The RET tyrosine kinase receptor has emerged as a target in thyroid and endocrine resistant breast cancer. We previously reported the synthesis of kinase inhibitors with potent activity against RET. H...

Pharmacological inhibition of dynamin II reduces constitutive protein secretion from primary human macrophages.

PLoS ONE 9(10) , e111186, (2014)

Dynamins are fission proteins that mediate endocytic and exocytic membrane events and are pharmacological therapeutic targets. These studies investigate whether dynamin II regulates constitutive prote...

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