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甲磺酸普立地诺

甲磺酸普立地诺用途

甲磺酸普利地诺是一种口服活性强的中枢抗胆碱能药物,可作为肌肉松弛剂[1]。

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甲磺酸普立地诺名称

[ CAS 号 ]:
6856-31-1

[ 中文名 ]:
Alpha,Alpha-二苯基-1-哌啶丙醇

[ 英文名 ]:
Pridinol Methanesulfonate Salt

[中文别名 ]:

[英文别名 ]:

甲磺酸普立地诺生物活性

[ 描述 ]:

甲磺酸普利地诺是一种口服活性强的中枢抗胆碱能药物,可作为肌肉松弛剂[1]。

[ 相关类别 ]:

研究领域 >> 神经疾病

信号通路 >> 神经信号通路 >> 疼痛

[参考文献]

[1]. Richter M, et al. Pharmacokinetics of oral pridinol: Results of a randomized, crossover bioequivalence trial in healthy subjects. Int J Clin Pharmacol Ther. 2021 Jun;59(6):471-477.

[2]. Duperray, B., et al. The fate of pridinol in the organism: Pharmacokinetics and distribution in animals. European Journal of Drug Metabolism and Pharmacokinetics 2, 121–130 (1977).

甲磺酸普立地诺物理化学性质

[ 沸点 ]:
585.1ºC at 760 mmHg

[ 熔点 ]:
152.5-155ºC

[ 分子式 ]:
C₂₁H₂₉NO₄S

[ 分子量 ]:
391.52400

[ 闪点 ]:
307.6ºC

[ 精确质量 ]:
391.18200

[ PSA ]:
86.22000

[ LogP ]:
4.32120

[ 外观性状 ]:
白色至灰白色结晶粉末

[ 储存条件 ]:
2-8°C

甲磺酸普立地诺安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H302-H312-H332

[ 警示性声明 ]:
P280

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xn: Harmful;

[ 风险声明 (欧洲) ]:
R20/21/22

[ 安全声明 (欧洲) ]:
36

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

甲磺酸普立地诺文献

Anticataleptic effect of taurine: interaction with antiparkinsonian agents.

Pol. J. Pharmacol. Pharm. 39(4) , 329-35, (1987)

The influence of taurine on cataleptogenic effect of neuroleptics was investigated in male Wistar rats. It was found that taurine 900 micrograms/rat icv reduced significantly haloperidol or fluphenazi...

Suicide by multidrug ingestion: hypothesis on the role played by the self-administration of activated charcoal.

Am. J. Forensic Med. Pathol. 28(1) , 55-8, (2007)

A fatal suicidal ingestion of drugs, together with activated charcoal, is reported. The death occurred 31 hours after the self-administration. The autopsy revealed a large amount of gastric content th...

Pridinolum mesylate and neuroleptic malignant syndrome.

Am. J. Psychiatry 142(3) , 389-90, (1985)

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