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ACTH (7-38) (human)

ACTH (7-38) (human)用途

ACTH(7-38)(人)是人ACTH(1-39)的7-38片段。人ACTH(1-39)被称为促肾上腺皮质激素抑制肽(CIP),是ACTH受体的拮抗剂,不具有任何皮质类固醇活性[1]。

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ACTH (7-38) (human)名称

[ CAS 号 ]:
68563-24-6

[ 英文名 ]:
ACTH (7-38) (human)

[英文别名 ]:

FRWGKPVGKKRRPVKVYPNGAEDESAEAFPLE

ACTH (7-38) (human)生物活性

[ 描述 ]:

ACTH(7-38)(人)是人ACTH(1-39)的7-38片段。人ACTH(1-39)被称为促肾上腺皮质激素抑制肽(CIP),是ACTH受体的拮抗剂,不具有任何皮质类固醇活性[1]。

[ 相关类别 ]:

研究领域 >> 代谢疾病

信号通路 >> G 蛋白偶联受体/G 蛋白 >> 黑皮素受体

[参考文献]

[1]. Verma PS, et.al. Inhibition of canine lung angiotensin converting enzyme by ACTH and structurally related peptides. Biochem Biophys Res Commun. 1982 Feb 26;104(4):1484-8.

ACTH (7-38) (human)物理化学性质

[ 分子式 ]:
C₁₆₇H₂₅₇N₄₇O₄₆

[ 分子量 ]:
3659.11

ACTH (7-38) (human)安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危险品运输编码 ]:
NONH for all modes of transport

ACTH (7-38) (human)文献

Gastric inhibitory polypeptide stimulates glucocorticoid secretion in rats, acting through specific receptors coupled with the adenylate cyclase-dependent signaling pathway.

Peptides 20(5) , 589-94, (1999)

Gastric inhibitory polypeptide (GIP) is a 42-amino acid peptide, belonging to the VIP-secretin-glucagon superfamily, some members of this group are able to regulate adrenocortical function. GIP-recept...

Evidence that an extrahypothalamic pituitary corticotropin-releasing hormone (CRH)/adrenocorticotropin (ACTH) system controls adrenal growth and secretion in rats.

Cell Tissue Res. 272(3) , 439-45, (1993)

Within two weeks, hypophysectomy induced in rats a striking decrease in the level of circulating ACTH (the concentration of which was at the limit of sensitivity of our assay system), coupled with a n...

Adrenocorticotrophic hormone modulates Escherichia coli O157:H7 adherence to porcine colonic mucosa.

Stress 8(3) , 185-90, (2005)

Exposure to stress is associated with susceptibility to disease and one stress mediator, norepinephrine, has been reported to enhance the adherence of enterohemorrhagic Escherichia coli O157:H7 (EHEC)...

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