娃兒藤鹼
娃兒藤鹼名称
[ CAS 号 ]:
6879-02-3
[ 中文名 ]:
娃兒藤鹼
[ 英文名 ]:
Dibenzo[f,h]pyrrolo[1,2-b]isoquinoline,9,11,12,13,13a,14-hexahydro-2,3,5,6-tetramethoxy-, (13aR)-
[英文别名 ]:
- Tylocerebrine
- (-)-(R)-tylocrebrine
- Tylocrebrin
- Lylocrebrine
- Tylocrebine
娃兒藤鹼物理化学性质
[ 密度 ]:
1.26g/cm3
[ 沸点 ]:
559.9ºC at 760 mmHg
[ 分子式 ]:
C24H27NO4
[ 分子量 ]:
393.47500
[ 闪点 ]:
160.5ºC
[ 精确质量 ]:
393.19400
[ PSA ]:
40.16000
[ LogP ]:
4.48580
[ 蒸汽压 ]:
1.44E-12mmHg at 25°C
[ 折射率 ]:
1.657
娃兒藤鹼毒性和生态
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- YP0175000
- CHEMICAL NAME :
- Tylocrebrine
- CAS REGISTRY NUMBER :
- 6879-02-3
- LAST UPDATED :
- 199612
- DATA ITEMS CITED :
- 6
- MOLECULAR FORMULA :
- C24-H27-N-O4
- MOLECULAR WEIGHT :
- 393.52
- WISWESSER LINE NOTATION :
- T D5 B6 K666 DNJ MO1 NO1 RO1 SO1
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 65 mg/kg
- TOXIC EFFECTS :
- Behavioral - changes in motor activity (specific assay) Gastrointestinal - hypermotility, diarrhea Skin and Appendages - hair
- REFERENCE :
- NCICP* Progress Report Submitted to the National Cancer Institute by Charles Pfizer & Co. Volume(issue)/page/year: -,77,1964
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 32 mg/kg
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity) Behavioral - ataxia Gastrointestinal - hypermotility, diarrhea
- REFERENCE :
- NCICP* Progress Report Submitted to the National Cancer Institute by Charles Pfizer & Co. Volume(issue)/page/year: -,77,1964
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 50 mg/kg
- TOXIC EFFECTS :
- Behavioral - changes in motor activity (specific assay) Behavioral - ataxia Gastrointestinal - hypermotility, diarrhea
- REFERENCE :
- NCICP* Progress Report Submitted to the National Cancer Institute by Charles Pfizer & Co. Volume(issue)/page/year: -,77,1964
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 42 mg/kg
- TOXIC EFFECTS :
- Behavioral - tremor Behavioral - convulsions or effect on seizure threshold Behavioral - ataxia
- REFERENCE :
- NCICP* Progress Report Submitted to the National Cancer Institute by Charles Pfizer & Co. Volume(issue)/page/year: -,77,1964 ** OTHER MULTIPLE DOSE TOXICITY DATA **
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Mammal - dog
- DOSE/DURATION :
- 12 mg/kg/24D-I
- TOXIC EFFECTS :
- Gastrointestinal - changes in structure or function of esophagus Gastrointestinal - ulceration or bleeding from large intestine Blood - other changes
- REFERENCE :
- NCICP* Progress Report Submitted to the National Cancer Institute by Charles Pfizer & Co. Volume(issue)/page/year: -,77,1964
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Primate - monkey
- DOSE/DURATION :
- 24 mg/kg/24D-I
- TOXIC EFFECTS :
- Liver - other changes Blood - pigmented or nucleated red blood cells Blood - changes in erythrocyte (RBC) count
- REFERENCE :
- NCICP* Progress Report Submitted to the National Cancer Institute by Charles Pfizer & Co. Volume(issue)/page/year: -,77,1964
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