< 生产厂家价格 >

2-氨基-4-甲基吡啶

2-氨基-4-甲基吡啶用途

氨基吡啶(Ascensil)是一种有效且非选择性的NO合成酶(NOS)同功酶(iNOS、nNOS、eNOS)抑制剂[1]。

点击显示

2-氨基-4-甲基吡啶名称

[ CAS 号 ]:
695-34-1

[ 中文名 ]:
2-氨基-4-甲基吡啶

[ 英文名 ]:
Aminopicoline

[中文别名 ]:

[英文别名 ]:

2-amino-4-Me-pyridine
2-Amino-4-meyhylpyrimidine
MFCD00149166
2-Pyridinamine,4-methyl
4-methyl-pyridin-2-ylamine
4-Methyl-2-aminopyridine
2-Amino-4-methylpyridine
2-Amino-4-picoline
2-amino-4-methyl-pyridine
4-Methylpyridin-2-amin

2-氨基-4-甲基吡啶生物活性

[ 描述 ]:

氨基吡啶(Ascensil)是一种有效且非选择性的NO合成酶(NOS)同功酶(iNOS、nNOS、eNOS)抑制剂[1]。

[ 相关类别 ]:

研究领域 >> 其他

信号通路 >> 免疫及炎症 >> 一氧化氮合酶

[参考文献]

[1]. Boer R, et al. The inhibitory potency and selectivity of arginine substrate site nitric-oxide synthase inhibitors is solely determined by their affinity toward the different isoenzymes. Mol Pharmacol. 2000;58(5):1026-1034.

2-氨基-4-甲基吡啶物理化学性质

[ 密度 ]:
1.1±0.1 g/cm3

[ 沸点 ]:
227.4±20.0 °C at 760 mmHg

[ 熔点 ]:
96-99 °C(lit.)

[ 分子式 ]:
C₆H₈N₂

[ 分子量 ]:
108.141

[ 闪点 ]:
114.0±9.0 °C

[ 精确质量 ]:
108.068748

[ PSA ]:
38.91000

[ LogP ]:
1.08

[ 外观性状 ]:
米色结晶粉末

[ 蒸汽压 ]:
0.1±0.4 mmHg at 25°C

[ 折射率 ]:
1.574

[ 储存条件 ]:
库房通风低温干燥

[ 水溶解性 ]:
SOLUBLE

2-氨基-4-甲基吡啶MSDS

2-氨基-4-甲基吡啶毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: TJ5150000

CHEMICAL NAME :: 4-Picoline, 2-amino-

CAS REGISTRY NUMBER :: 695-34-1

BEILSTEIN REFERENCE NO. :: 0107066

LAST UPDATED :: 199701

DATA ITEMS CITED :: 6

MOLECULAR FORMULA :: C6-H8-N2

MOLECULAR WEIGHT :: 108.16

WISWESSER LINE NOTATION :: T6NJ BZ D1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 200 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year: -,841,1986

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 160 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: AEPPAE Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. (Berlin, Ger.) V.110-253, 1925-66. For publisher information, see NSAPCC. Volume(issue)/page/year: 227,234,1955

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 64 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Behavioral - excitement

REFERENCE :: NYKZAU Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. (Nippon Yakuri Gakkai, c/o Kyoto Daigaku Igakubu Yakurigaku Kyoshitsu, Konoe-cho, Yoshida, Sakyo-ku, Kyoto 606, Japan) V.40- 1944- Volume(issue)/page/year: 53,227S,1957

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 39 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold

REFERENCE :: APFRAD Annales Pharmaceutiques Francaises. (SPPIF, B.P.22, F-41353 Vineuil, France) V.1- 1943- Volume(issue)/page/year: 26,345,1968

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year: -,841,1986

点击显示

2-氨基-4-甲基吡啶安全信息

[ 符号 ]:

GHS06, GHS08

[ 信号词 ]:
Danger

[ 危害声明 ]:
H301 + H311 + H331-H373

[ 警示性声明 ]:
P261-P280-P301 + P310-P311

[ 个人防护装备 ]:
Eyeshields;Faceshields;Gloves;type P2 (EN 143) respirator cartridges

[ 危害码 (欧洲) ]:
T:Toxic

[ 风险声明 (欧洲) ]:
R25;R36/37/38

[ 安全声明 (欧洲) ]:
S53-S45-S60-S61-S37/39-S28A-S26-S36/37/39

[ 危险品运输编码 ]:
UN 3086 6.1/PG 1

[ WGK德国 ]:
3

[ RTECS号 ]:
TJ5150000

[ 包装等级 ]:
II

[ 危险类别 ]:
6.1

[ 海关编码 ]:
2932999099

2-氨基-4-甲基吡啶合成路线

2-氨基-4-甲基吡啶上下游产品

2-氨基-4-甲基吡啶上游产品

2-氨基-4-甲基吡啶下游产品

2-氨基-4-甲基吡啶海关

[ 海关编码 ]: 2933399090

[ 中文概述 ]:
2933399090. 其他结构含非稠合吡啶环的化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期

[ Summary ]:
2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

2-氨基-4-甲基吡啶文献

Guide to Receptors and Channels (GRAC), 4th Edition.

Br. J. Pharmacol. 158 Suppl 1 , S1-254, (2009)

Synthesis and evaluation of pyrido[1,2-a]pyrimidines as inhibitors of nitric oxide synthases.

Eur. J. Med. Chem. 44 , 2877-87, (2009)

A series of new 3-aroylpyrido[1,2-a]pyrimidines were synthesized from aryl methyl ketones in a simple two-step procedure and evaluated as nitric oxide synthases (NOS) inhibitors. In order to perform a...

Actions of 4-methyl-2-aminopyridine on neuromuscular transmission and contractility of skeletal muscle.

Eur. J. Pharmacol. 70(1) , 53-7, (1981)

4-Methyl-2-aminopyridine (4M2AP) increased responses of isolated rat diaphragm and chick biventer cervicis nerve-muscle preparations to nerve stimulation but depressed responses to direct stimulation....

更多文献