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美芬诺酮

美芬诺酮用途

Mephenoxalone 抑制神经元传递,通过抑制反射弧使骨骼肌放松。

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美芬诺酮名称

[ CAS 号 ]:
70-07-5

[ 中文名 ]:
美芬诺酮

[ 英文名 ]:
mephenoxalone

[中文别名 ]:

5-[(2-甲氧基苯氧基)甲基]-2-恶唑烷酮

[英文别名 ]:

Control-OM
5-[(2-Methoxyphenoxy)methyl]-1,3-oxazolidin-2-one
2-Oxazolidinone, 5-[(2-methoxyphenoxy)methyl]-
Mefenoxalona
Mefenoxalone
EINECS 200-723-3
mephenoxalone
Moderamin
Methoxydone
5-[(2-Methoxyphenoxy)methyl]-2-oxazolidinone

美芬诺酮生物活性

[ 描述 ]:

Mephenoxalone 抑制神经元传递,通过抑制反射弧使骨骼肌放松。

[ 相关类别 ]:

信号通路 >> 其他 >> 其他

研究领域 >> 神经疾病

[参考文献]

[1]. K F BENITZ, et al. Toxicity studies on mephenoxalone in rats and dogs. Toxicol Appl Pharmacol (IF: 4.22; Q2). 1962 Mar;4:220-37.

美芬诺酮物理化学性质

[ 密度 ]:
1.2±0.1 g/cm3

[ 沸点 ]:
440.0±18.0 °C at 760 mmHg

[ 分子式 ]:
C₁₁H₁₃NO₄

[ 分子量 ]:
223.23

[ 闪点 ]:
219.9±21.2 °C

[ 精确质量 ]:
223.084457

[ PSA ]:
56.79000

[ LogP ]:
1.32

[ 蒸汽压 ]:
0.0±1.1 mmHg at 25°C

[ 折射率 ]:
1.521

美芬诺酮毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: RQ3500000

CHEMICAL NAME :: 2-Oxazolidinone, 5-((o-methoxyphenoxy)methyl)-

CAS REGISTRY NUMBER :: 70-07-5

LAST UPDATED :: 199612

DATA ITEMS CITED :: 7

MOLECULAR FORMULA :: C11-H13-N-O4

MOLECULAR WEIGHT :: 223.25

WISWESSER LINE NOTATION :: T5MVOTJ D1OR BO1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 3820 mg/kg

TOXIC EFFECTS :: Sense Organs and Special Senses (Eye) - ptosis Behavioral - changes in motor activity (specific assay) Lungs, Thorax, or Respiration - respiratory depression

REFERENCE :: TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 6,642,1964

TYPE OF TEST :: LD - Lethal dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >1 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 134,198,1961

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >5 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: PSDTAP Proceedings of the European Society for the Study of Drug Toxicity. (Princeton, NJ 08540) V.1-15, 1963-74. For publisher information, see PESTD5. Volume(issue)/page/year: 11,212,1970

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 800 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: RAMAAB Revista de la Asociacion Medica Argentina. (Buenos Aires, Argentina) V.1-89, 1915-76. Discontinued. Volume(issue)/page/year: 74,82,1960 ** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 30330 mg/kg/30D-C

TOXIC EFFECTS :: Nutritional and Gross Metabolic - weight loss or decreased weight gain Related to Chronic Data - changes in ovarian weight

REFERENCE :: TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 4,220,1962

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 18 gm/kg/30D-I

TOXIC EFFECTS :: Behavioral - food intake (animal) Liver - other changes Blood - normocytic anemia

REFERENCE :: TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 4,220,1962

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 87 gm/kg/26W-I

TOXIC EFFECTS :: Behavioral - ataxia Blood - normocytic anemia

REFERENCE :: TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 4,220,1962

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美芬诺酮安全信息

[ 海关编码 ]:
2934999090

美芬诺酮合成路线

详细合成路线

美芬诺酮上下游产品

美芬诺酮上游产品

美芬诺酮下游产品

美芬诺酮海关

[ 海关编码 ]: 2934999090

[ 中文概述 ]:
2934999090. 其他杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%