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卡巴泽伦

卡巴泽伦用途

卡巴泽兰是一种有效的磷酸二酯酶抑制剂,是醛氧化酶的底物。卡巴泽兰可用于代谢性疾病的研究[1]。

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卡巴泽伦名称

[ CAS 号 ]:
70724-25-3

[ 中文名 ]:
卡巴折伦

[ 英文名 ]:
carbazeran

[中文别名 ]:

卡巴泽伦

[英文别名 ]:

carbazeran

卡巴泽伦生物活性

[ 描述 ]:

卡巴泽兰是一种有效的磷酸二酯酶抑制剂,是醛氧化酶的底物。卡巴泽兰可用于代谢性疾病的研究[1]。

[ 相关类别 ]:

信号通路 >> 代谢酶/蛋白酶 >> 磷酸二酯酶(PDE)

研究领域 >> 代谢疾病

[参考文献]

[1]. Uehara S, et al. Human Aldehyde Oxidase 1-Mediated Carbazeran Oxidation in Chimeric TK-NOG Mice Transplanted with Human Hepatocytes. Drug Metab Dispos. 2020 Jul;48(7):580-586.

卡巴泽伦物理化学性质

[ 密度 ]:
1.3±0.1 g/cm3

[ 沸点 ]:
595.6±50.0 °C at 760 mmHg

[ 分子式 ]:
C₁₈H₂₄N₄O₄

[ 分子量 ]:
360.408

[ 闪点 ]:
314.0±30.1 °C

[ 精确质量 ]:
360.179749

[ PSA ]:
85.81000

[ LogP ]:
1.38

[ 外观性状 ]:
粉末

[ 蒸汽压 ]:
0.0±1.7 mmHg at 25°C

[ 折射率 ]:
1.600

[ 储存条件 ]:
2-8°C

卡巴泽伦MSDS

卡巴泽伦安全信息

[ 符号 ]:

GHS06

[ 信号词 ]:
Danger

[ 危害声明 ]:
H301

[ 警示性声明 ]:
P301 + P310

[ 危害码 (欧洲) ]:
T

[ 危险品运输编码 ]:
UN 2811 6.1 / PGIII

[ 海关编码 ]:
2933990090

卡巴泽伦合成路线

卡巴泽伦上下游产品

卡巴泽伦上游产品

卡巴泽伦下游产品

卡巴泽伦海关

[ 海关编码 ]: 2933990090

[ 中文概述 ]:
2933990090. 其他仅含氮杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

卡巴泽伦文献

Aldehyde oxidase activity in fresh human skin.

Drug Metab. Dispos. 42(12) , 2049-57, (2014)

Human aldehyde oxidase (AO) is a molybdoflavoenzyme that commonly oxidizes azaheterocycles in therapeutic drugs. Although high metabolic clearance by AO resulted in several drug failures, existing in ...

A novel reaction mediated by human aldehyde oxidase: amide hydrolysis of GDC-0834.

Drug Metab. Dispos. 43 , 908-15, (2015)

GDC-0834, a Bruton's tyrosine kinase inhibitor investigated as a potential treatment of rheumatoid arthritis, was previously reported to be extensively metabolized by amide hydrolysis such that no mea...

Chronotropic and inotropic actions of amrinone, carbazeran and isobutylmethyl xanthine: role of phosphodiesterase inhibition.

Br. J. Pharmacol. 98 , 291-301, (1999)

1. The chronotropic and inotropic effects of amrinone, carbazeran and 3-isobutyl-1-methyl xanthine (IBMX) were examined in isolated preparations of papillary muscle and right atria from rabbit heart. ...

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