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氯化琥珀胆碱

氯化琥珀胆碱用途

氯化琥珀胆碱为骨骼肌松弛药（全麻用骨骼肌松弛药）。临床用作全身麻醉时的肌肉松弛剂，另氯化琥珀胆碱在控制破伤风患者的肌肉痉挛方面有较好的疗效。氯化琥珀胆碱肌肉松弛作用快，持续时间短，易于控制，故适用于外科手术，可使气管插管更容易进行。

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氯化琥珀胆碱名称

[ CAS 号 ]:
71-27-2

[ 中文名 ]:
司可林

[ 英文名 ]:
Suxamethonium chloride

[中文别名 ]:

[英文别名 ]:

Succinylcholine Chloride
Suxamethonium chloride
QUELICIN
Succinylcholine dichloride
Succinyldicholine chloride
MFCD00038725
succinylcholine chloride (anhydrous)
Succinylcholine Chloride Dihydrate
Listenon
Ultrapal Chloride

氯化琥珀胆碱物理化学性质

[ 熔点 ]:
164ºC

[ 分子式 ]:
C₁₄H₃₀Cl₂N₂O₄

[ 分子量 ]:
361.305

[ 精确质量 ]:
360.158264

[ PSA ]:
52.60000

[ 外观性状 ]:
白色粉末

[ 储存条件 ]:
Refrigerator

[ 稳定性 ]:
Stable. Combustible. Incompatible with strong oxidizing agents.

氯化琥珀胆碱MSDS

详细MSDS(安全技术说明书)

氯化琥珀胆碱毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: GA2360000

CAS REGISTRY NUMBER :: 71-27-2

LAST UPDATED :: 199706

DATA ITEMS CITED :: 10

MOLECULAR FORMULA :: C14-H30-N2-O4.2Cl

MOLECULAR WEIGHT :: 361.36

WISWESSER LINE NOTATION :: 1K1&1&2OV2VO2K1&1&1 &Q 2 &G 2

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Human - man

DOSE/DURATION :: 1429 ug/kg

TOXIC EFFECTS :: Nutritional and Gross Metabolic - changes in potassium

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Human - man

DOSE/DURATION :: 7 mg/kg

TOXIC EFFECTS :: Nutritional and Gross Metabolic - changes in potassium Cardiac - arrhythmias (including changes in conduction)

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1250 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 430 ug/kg

TOXIC EFFECTS :: Peripheral Nerve and Sensation - flaccid paralysis without anesthesia (usually neuromuscular blockage) Behavioral - altered sleep time (including change in righting reflex) Lungs, Thorax, or Respiration - cyanosis

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 240 ug/kg

TOXIC EFFECTS :: Sense Organs and Special Senses (Eye) - effect, not otherwise specified Behavioral - altered sleep time (including change in righting reflex) Behavioral - rigidity (including catalepsy)

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Bird - chicken

DOSE/DURATION :: 300 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TEST SYSTEM :: Rodent - mouse

DOSE/DURATION :: 2500 ug/kg

REFERENCE :: MSCREJ Medical Science Research. (Elsevier Applied Science Pub. Ltd., Crown House, Linton Rd., Barking, Essex IG11 8JU, UK) V.15- 1987- Volume(issue)/page/year: 20,759,1992 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 84013 No. of Facilities: 25 (estimated) No. of Industries: 1 No. of Occupations: 2 No. of Employees: 400 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 84013 No. of Facilities: 207 (estimated) No. of Industries: 1 No. of Occupations: 4 No. of Employees: 10334 (estimated) No. of Female Employees: 9106 (estimated)

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氯化琥珀胆碱安全信息

[ 安全声明 (欧洲) ]:
7-8

[ 危险品运输编码 ]:
UN 3249

[ RTECS号 ]:
GA2360000

[ 包装等级 ]:
III

[ 危险类别 ]:
6.1(b)

[ 海关编码 ]:
2923900090

氯化琥珀胆碱合成路线

详细合成路线

氯化琥珀胆碱上下游产品

氯化琥珀胆碱上游产品

氯化琥珀胆碱下游产品

氯化琥珀胆碱海关

[ 海关编码 ]: 2923900090

[ 中文概述 ]:
2923900090 其他季铵盐及季铵碱。监管条件:无。增值税率:17.0%。退税率:9.0%。最惠国关税:6.5%。普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2923900090 other quaternary ammonium salts and hydroxides。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:30.0%