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氯化胆碱

氯化胆碱用途

Choline chloride是一种有机化合物和季铵盐, 是酰基受体和胆碱乙酰转移酶的底物, 是一种植物光合作用促进剂, 也作禽畜饲料添加剂, 刺激产蛋产仔。

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氯化胆碱名称

[ CAS 号 ]:
67-48-1

[ 中文名 ]:
氯化胆碱

[ 英文名 ]:
Choline chloride

[中文别名 ]:

[英文别名 ]:

Lipotril
[3H]-Choline chloride
2-hydroxyethyltrimethyl ammonium chloride
trimethyl-(2-hydroxyethyl)ammonium chloride
Colina cloruro [DCIT]
Actiron CC 6
(2-hydroxyethyl)trimethyl-Ammonium chloride
MFCD00011721
(β-Hydroxyethyl)trimethylammonium chloride
Neocolina

氯化胆碱生物活性

[ 描述 ]:

Choline chloride是一种有机化合物和季铵盐, 是酰基受体和胆碱乙酰转移酶的底物, 是一种植物光合作用促进剂, 也作禽畜饲料添加剂, 刺激产蛋产仔。

[ 相关类别 ]:

信号通路 >> 其他 >> 其他

研究领域 >> 其他

[相关活性小分子]

氯化胆碱物理化学性质

[ 密度 ]:
1.205 g/cm3

[ 熔点 ]:
302-305 °C (dec.)(lit.)

[ 分子式 ]:
C₅H₁₄ClNO

[ 分子量 ]:
139.624

[ 精确质量 ]:
139.076385

[ PSA ]:
20.23000

[ 外观性状 ]:
白色结晶粉末

[ 储存条件 ]:
0-6°C

[ 稳定性 ]:
Stable. Incompatible with strong oxidizing agents, moisture. Store under a dry atmosphere.

[ 水溶解性 ]:
soluble

氯化胆碱MSDS

氯化胆碱毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: KH2975000

CHEMICAL NAME :: Ethanaminium, 2-hydroxy-N,N,N-trimethyl-, chloride

CAS REGISTRY NUMBER :: 67-48-1

LAST UPDATED :: 199701

DATA ITEMS CITED :: 24

MOLECULAR FORMULA :: C5-H14-N-O.Cl

MOLECULAR WEIGHT :: 139.65

WISWESSER LINE NOTATION :: Q2K1&1&1 &Q &G

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 3400 mg/kg

TOXIC EFFECTS :: Sense Organs and Special Senses (Eye) - chromodacryorrhea Behavioral - excitement Lungs, Thorax, or Respiration - respiratory depression

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 450 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 3900 mg/kg

TOXIC EFFECTS :: Sense Organs and Special Senses (Eye) - lacrimation Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - respiratory depression

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 320 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 735 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 53 mg/kg

TOXIC EFFECTS :: Sense Organs and Special Senses (Eye) - lacrimation Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - respiratory depression

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 5 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Mammal - cat

DOSE/DURATION :: 25 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 500 mg/kg

TOXIC EFFECTS :: Sense Organs and Special Senses (Eye) - corneal damage Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - other changes

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 1 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 1100 ug/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - cyanosis Gastrointestinal - changes in structure or function of salivary glands

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Rectal

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 1 gm/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - cyanosis Gastrointestinal - changes in structure or function of salivary glands

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Amphibian - frog

DOSE/DURATION :: 1500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 331 mg/kg/14W-C

TOXIC EFFECTS :: Nutritional and Gross Metabolic - weight loss or decreased weight gain

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 4950 mg/kg/30D-I

TOXIC EFFECTS :: Lungs, Thorax, or Respiration - changes in lung weight Liver - changes in liver weight Endocrine - changes in thymus weight

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 6250 mg/kg/10W-I

TOXIC EFFECTS :: Related to Chronic Data - death

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 3564 mg/kg/5W-I

TOXIC EFFECTS :: Liver - changes in liver weight Endocrine - changes in thymus weight Blood - changes in spleen

MUTATION DATA

TYPE OF TEST :: Sister chromatid exchange

TEST SYSTEM :: Rodent - hamster Ovary

DOSE/DURATION :: 500 ug/L

REFERENCE :: ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For publisher information, see EMMUEG. Volume(issue)/page/year: 7,1,1985 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-RUSSIA:STEL 0.2 mg/m3 JAN 1993 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 19130 No. of Facilities: 198 (estimated) No. of Industries: 3 No. of Occupations: 12 No. of Employees: 2813 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 19130 No. of Facilities: 2227 (estimated) No. of Industries: 10 No. of Occupations: 30 No. of Employees: 31203 (estimated) No. of Female Employees: 8214 (estimated)

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氯化胆碱安全信息

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xi:Irritant

[ 风险声明 (欧洲) ]:
R36/37/38

[ 安全声明 (欧洲) ]:
S26-S36

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
1

[ RTECS号 ]:
KH2975000

[ 海关编码 ]:
2923100000

氯化胆碱合成路线

氯化胆碱上下游产品

氯化胆碱上游产品

氯化胆碱下游产品

氯化胆碱制备

1）连续法制备氯化胆碱溶液的三甲胺盐酸盐与一定量的环氧乙烷分别用泵连续送入反应器，反应物在反应器内的停留时间为1-1.5h。反应在搅拌下进行，生成物连续引出，使反应器内的液面保持稳定。反应器引出的氯化胆碱粗产品进入汽提塔，从塔底获得60-80%氯化胆碱液体产品。（2）三甲胺盐酸盐与环氧乙烷反应，然后加有机酸中和并浓缩，制取氯化胆碱。（3）氯乙醇与三甲胺反应制取氯化胆碱。

由三甲胺与环氧乙烷反应而得产品。也可用氯乙醇在少量环氧乙烷或碱性物质催化下，与三甲胺反应而得产品。

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氯化胆碱海关

[ 海关编码 ]: 2923100000

氯化胆碱文献

Choline partially prevents the impact of ethanol on the lipid raft dependent functions of l1 cell adhesion molecule.

Alcohol. Clin. Exp. Res. 38(11) , 2722-30, (2014)

Fetal alcohol spectrum disorder, the leading known cause of mental retardation, is caused by alcohol exposure during pregnancy. One mechanism of ethanol (EtOH) teratogenicity is the disruption of the ...

Pregnancy and lactation alter biomarkers of biotin metabolism in women consuming a controlled diet.

J. Nutr. 144(12) , 1977-84, (2014)

Biotin functions as a cofactor for several carboxylase enzymes with key roles in metabolism. At present, the dietary requirement for biotin is unknown and intake recommendations are provided as Adequa...

Highly efficient extraction of anthocyanins from grape skin using deep eutectic solvents as green and tunable media.

Arch. Pharm. Res. 38 , 2143-52, (2015)

Deep eutectic solvents (DESs) were investigated as tunable, environmentally benign, yet superior extraction media to enhance the extraction of anthocyanins from grape skin, which is usually discarded ...

更多文献

氯化胆碱

氯化胆碱用途

氯化胆碱名称

氯化胆碱生物活性

氯化胆碱物理化学性质

氯化胆碱MSDS

详细MSDS(安全技术说明书)

氯化胆碱毒性和生态

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

氯化胆碱安全信息

氯化胆碱合成路线

详细合成路线

氯化胆碱上下游产品

氯化胆碱上游产品

氯化胆碱下游产品

氯化胆碱制备

氯化胆碱海关

氯化胆碱文献

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