5-羟基癸酸钠

5-羟基癸酸钠用途

5-Hydroxydecanoate sodium 是一种选择性 ATP 敏感的 K+ (KATP) 通道阻滞剂 (IC50 约为 30 μM)。5-Hydroxydecanoate sodium 是线粒体外膜酰基辅酶 A 合成酶的底物,并具有抗氧化活性。

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5-羟基癸酸钠名称

[ CAS 号 ]:
71186-53-3

[ 中文名 ]:
5-羟基癸酸钠盐

[ 英文名 ]:
5-Hydroxydecanoate sodium

[中文别名 ]:

5-羟基癸酸钠

[英文别名 ]:

5-HYDROXYDECANOATE NA
Sodium 5-hydroxydecanoate
5-HYDROXYDECANOIC ACID SODIUM

5-羟基癸酸钠生物活性

[ 描述 ]:

[ 相关类别 ]:

研究领域 >> 神经疾病

信号通路 >> 跨膜转运 >> 钾通道

[ 靶点 ]

IC50: ~30 μM (KATP)

[体外研究]

5-羟基癸酸盐(5-HD)治疗可消除盐酸戊乙奎醚(PHC)预处理对缺氧/复氧(A/R)诱导的H9c2细胞损伤的有益作用。5-羟基癸酸盐阻断PHC对Ca2+超载和ROS产生的抑制作用。5-羟基癸酸盐促进Cyt-C从线粒体释放到细胞质中。5-羟基癸酸盐减弱PHC的抗凋亡作用。PHC治疗可显著降低Bax和裂解caspase-3水平,升高Bcl-2水平。5-羟基癸酸预处理逆转了PHC对其表达水平的影响。5-羟基癸酸盐阻断PHC对KATP通道的影响[1]。

[体内研究]

5-羟基癸酸盐(100μM)治疗可消除缺血预处理(IPC)对收缩恢复的影响,且不影响其对大鼠挛缩、乳酸生成、糖原分解和活组织的影响[3]。

[参考文献]

[1]. Congna Zi, et al. Penehyclidine hydrochloride protects against anoxia/reoxygenation injury in cardiomyocytes through ATP-sensitive potassium channels, and the Akt/GSK-3β and Akt/mTOR signaling pathways. Cell Biol Int. 2020 Jun;44(6):1353-1362.

[2]. Xiantao Li, et al. 5-Hydroxydecanoate and coenzyme A are inhibitors of native sarcolemmal KATP channels in inside-out patches. Biochim Biophys Acta. 2010 Mar;1800(3):385-91.

[3]. M G Marina Prendes, et al. Effects of 5-hydroxydecanoate and ischemic preconditioning on the ischemic-reperfused heart of fed and fasted rats. J Physiol Biochem. 2005 Sep;61(3):447-56.

5-羟基癸酸钠物理化学性质

[ 沸点 ]:
320.8ºC at 760 mmHg

[ 分子式 ]:
C₁₀H₁₉NaO₃

[ 分子量 ]:
210.24600

[ 闪点 ]:
162ºC

[ 精确质量 ]:
210.12300

[ PSA ]:
60.36000

[ LogP ]:
0.84780

[ 外观性状 ]:
白色固体

[ 储存条件 ]:
室温

5-羟基癸酸钠MSDS

详细MSDS(安全技术说明书)

5-羟基癸酸钠安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

5-羟基癸酸钠文献

CYP-epoxygenases contribute to A2A receptor-mediated aortic relaxation via sarcolemmal KATP channels.

Am. J. Physiol. Regul. Integr. Comp. Physiol. 303(10) , R1003-10, (2012)

Previously, we have shown that A(2A) adenosine receptor (A(2A)AR) mediates aortic relaxation via cytochrome P-450 (CYP)-epoxygenases. However, the signaling mechanism is not understood properly. We hy...

Is preconditioning by oxytocin administration mediated by iNOS and/or mitochondrial K(ATP) channel activation in the in vivo anesthetized rabbit heart?

Life Sci. 90(19-20) , 763-9, (2012)

Oxytocin (OXT) pretreatment protects the heart during ischemia-reperfusion injury by activating ATP-dependent potassium (K(ATP)) channels. The aim of the current study was to elucidate the roles of ni...

Mitochondrial K+ channels are involved in ischemic postconditioning in rat hearts.

J. Physiol. Sci. 62(4) , 325-32, (2012)

The mitochondrial calcium-activated potassium channel (mitoK(Ca)) and the mitochondrial ATP-sensitive potassium channel (mitoK(ATP)) are both involved in cardiac preconditioning. Here, we examined whe...

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