氨苄青霉素,三水
氨苄青霉素,三水用途
氨苄青霉素,三水名称
[ CAS 号 ]:
7177-48-2
[ 中文名 ]:
氨苄青霉素
[ 英文名 ]:
Ampicillin Trihydrate
[中文别名 ]:
[英文别名 ]:
- Ampicillin
- MFCD00072036
- EINECS 200-709-7
- Ampicillin Trihydrate
氨苄青霉素,三水生物活性
[ 描述 ]:
[ 相关类别 ]:
[体外研究]
[体内研究]
[参考文献]
氨苄青霉素,三水物理化学性质
[ 沸点 ]:
683.9ºC at 760 mmHg
[ 熔点 ]:
208 °C (dec.)(lit.)
[ 分子式 ]:
C16H25N3O7S
[ 分子量 ]:
403.451
[ 闪点 ]:
367.4ºC
[ 精确质量 ]:
403.141327
[ PSA ]:
165.72000
[ LogP ]:
1.15430
[ 外观性状 ]:
无气味的白色微结晶粉末,带有一种苦味道
[ 折射率 ]:
265 ° (C=0.1, H2O)
[ 储存条件 ]:
库房通风低温干燥
[ 水溶解性 ]:
0.1-1 g/100 mL at 21 ºC
氨苄青霉素,三水MSDS
氨苄青霉素,三水毒性和生态
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- XH8425000
- CHEMICAL NAME :
- 4-Thia-1-azabicyclo(3.2.0)heptane-2-carboxylic acid, 6-(2-amino-2-phenylacetamido)- 3,3-dimethyl-7-oxo-, trihydrate, D- (-)-
- CAS REGISTRY NUMBER :
- 7177-48-2
- LAST UPDATED :
- 199707
- DATA ITEMS CITED :
- 14
- MOLECULAR FORMULA :
- C16-H19-N3-O4-S.3H2-O
- MOLECULAR WEIGHT :
- 403.50
- WISWESSER LINE NOTATION :
- T45 ANV ESTJ CMVYZR& F1 F1 GVQ &QH 3
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 10 gm/kg
- TOXIC EFFECTS :
- Behavioral - tremor Behavioral - muscle weakness Gastrointestinal - hypermotility, diarrhea
- REFERENCE :
- ANTBAL Antibiotiki. (Moscow, USSR) V.1-29, 1956-84. For publisher information, see AMBIEH. Volume(issue)/page/year: 20,653,1975
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 15200 mg/kg
- TOXIC EFFECTS :
- Behavioral - tremor Behavioral - muscle weakness Gastrointestinal - hypermotility, diarrhea
- REFERENCE :
- ANTBAL Antibiotiki. (Moscow, USSR) V.1-29, 1956-84. For publisher information, see AMBIEH. Volume(issue)/page/year: 20,653,1975 ** OTHER MULTIPLE DOSE TOXICITY DATA **
- TYPE OF TEST :
- TCLo - Lowest published toxic concentration
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 5 mg/m3/5H/17W-I
- TOXIC EFFECTS :
- Blood - other changes Immunological Including Allergic - decreased immune response Nutritional and Gross Metabolic - weight loss or decreased weight gain
- REFERENCE :
- ANTBAL Antibiotiki. (Moscow, USSR) V.1-29, 1956-84. For publisher information, see AMBIEH. Volume(issue)/page/year: 20,653,1975 ** REPRODUCTIVE DATA **
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- DOSE :
- 1500 mg/kg
- SEX/DURATION :
- female 6-11 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)
- REFERENCE :
- ANTBAL Antibiotiki. (Moscow, USSR) V.1-29, 1956-84. For publisher information, see AMBIEH. Volume(issue)/page/year: 18,815,1973
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- DOSE :
- 2800 mg/kg
- SEX/DURATION :
- female 7-13 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Specific Developmental Abnormalities - musculoskeletal system
- REFERENCE :
- KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 7,3113,1973
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- DOSE :
- 9100 mg/kg
- SEX/DURATION :
- female 7-13 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Fertility - litter size (e.g. # fetuses per litter; measured before birth)
- REFERENCE :
- KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 7,3113,1973
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- DOSE :
- 28 gm/kg
- SEX/DURATION :
- female 7-13 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Specific Developmental Abnormalities - musculoskeletal system
- REFERENCE :
- KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 7,3113,1973 *** REVIEWS *** IARC Cancer Review:Animal Limited Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 50,153,1990 IARC Cancer Review:Human Inadequate Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 50,153,1990 IARC Cancer Review:Group 3 IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 50,153,1990 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 81708 No. of Facilities: 2339 (estimated) No. of Industries: 3 No. of Occupations: 4 No. of Employees: 5081 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 81708 No. of Facilities: 861 (estimated) No. of Industries: 4 No. of Occupations: 13 No. of Employees: 13014 (estimated) No. of Female Employees: 7415 (estimated)
氨苄青霉素,三水安全信息
[ 符号 ]:
GHS07, GHS08
[ 信号词 ]:
Danger
[ 危害声明 ]:
H315-H317-H319-H334-H335
[ 警示性声明 ]:
P261-P280-P284-P304 + P340-P305 + P351 + P338-P342 + P311
[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Faceshields;Gloves
[ 危害码 (欧洲) ]:
Xn: Harmful;
[ 风险声明 (欧洲) ]:
R36/37/38;R42/43
[ 安全声明 (欧洲) ]:
S22-S26-S36/37
[ 危险品运输编码 ]:
NONH for all modes of transport
[ WGK德国 ]:
2
[ RTECS号 ]:
XH8425000
[ 海关编码 ]:
2941101100
氨苄青霉素,三水海关
[ 海关编码 ]: 2941101100
氨苄青霉素,三水文献
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BBS4 is one of several proteins whose defects cause Bardet-Biedl syndrome (BBS), a multi-systemic disorder, manifesting with marked obesity. BBS4 polymorphisms have been associated with common non-syn...
An HD-domain phosphodiesterase mediates cooperative hydrolysis of c-di-AMP to affect bacterial growth and virulence.Proc. Natl. Acad. Sci. U. S. A. 112(7) , E747-56, (2015)
The nucleotide cyclic di-3',5'- adenosine monophosphate (c-di-AMP) was recently identified as an essential and widespread second messenger in bacterial signaling. Among c-di-AMP-producing bacteria, al...
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