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L-苏氨酸

L-苏氨酸用途

L-Threonine 是一种天然氨基酸,可由微生物发酵产生,可用于食品、药品和饲料中。

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L-苏氨酸名称

[ CAS 号 ]:
72-19-5

[ 中文名 ]:
L-苏氨酸

[ 英文名 ]:
L-Threonine

[中文别名 ]:

[英文别名 ]:

EINECS 200-774-1
L-Tlhreonine
H-THR-OH
L-Threonine (JP15)
(2S,3R)-(-)-Threonine
L-α-Amino-β-hydroxybutyric acid
L-Threonine
2-Amino-3-hydroxybutanoic acid, (R-(R*,S*))-
UNII:TFM6DU5S6A
H-L-THR-OH

L-苏氨酸生物活性

[ 描述 ]:

L-Threonine 是一种天然氨基酸,可由微生物发酵产生,可用于食品、药品和饲料中。

[ 相关类别 ]:

研究领域 >> 其他

信号通路 >> 其他 >> 其他

[参考文献]

[1]. Zhao H, et al. Increasing L-threonine production in Escherichia coli by engineering the glyoxylate shunt and the L-threonine biosynthesis pathway. Appl Microbiol Biotechnol. 2018 Jul;102(13):5505-5518.

L-苏氨酸物理化学性质

[ 密度 ]:
1.3±0.1 g/cm3

[ 沸点 ]:
345.8±32.0 °C at 760 mmHg

[ 熔点 ]:
255ºC

[ 分子式 ]:
C₄H₉NO₃

[ 分子量 ]:
119.119

[ 闪点 ]:
162.9±25.1 °C

[ 精确质量 ]:
119.058243

[ PSA ]:
83.55000

[ LogP ]:
-1.23

[ 外观性状 ]:
白色结晶粉末

[ 蒸汽压 ]:
0.0±1.7 mmHg at 25°C

[ 折射率 ]:
1.507

[ 储存条件 ]:
室温

L-苏氨酸MSDS

L-苏氨酸毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: XO8590000

CHEMICAL NAME :: Threonine, L-

CAS REGISTRY NUMBER :: 72-19-5

LAST UPDATED :: 199709

DATA ITEMS CITED :: 5

MOLECULAR FORMULA :: C4-H9-N-O3

MOLECULAR WEIGHT :: 119.14

WISWESSER LINE NOTATION :: QY1&YZVQ -L

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 3098 mg/kg

TOXIC EFFECTS :: Behavioral - muscle contraction or spasticity Lungs, Thorax, or Respiration - dyspnea Nutritional and Gross Metabolic - body temperature decrease

MUTATION DATA

TYPE OF TEST :: Sister chromatid exchange

TEST SYSTEM :: Human Lymphocyte

DOSE/DURATION :: 10 mg/L

REFERENCE :: MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 372,75,1996 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 81868 No. of Facilities: 53 (estimated) No. of Industries: 1 No. of Occupations: 3 No. of Employees: 750 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 81868 No. of Facilities: 787 (estimated) No. of Industries: 3 No. of Occupations: 13 No. of Employees: 18524 (estimated) No. of Female Employees: 13980 (estimated)

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L-苏氨酸安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危害码 (欧洲) ]:
Xi

[ 风险声明 (欧洲) ]:
36/37/38

[ 安全声明 (欧洲) ]:
S24/25

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ RTECS号 ]:
XO8590000

[ 海关编码 ]:
29225000

L-苏氨酸合成路线

L-苏氨酸上下游产品

L-苏氨酸上游产品

L-苏氨酸下游产品

L-苏氨酸制备

1.用产谷氨酸小球菌或短杆菌、棒杆菌等使糖类、氨、高丝氨酸发酵后，再经过精制而制得，发酵液中浓度可达5～20g/L。

2.以巴豆酸或以甘氨酸为原料制得。也可以葡萄糖或淀粉为原料，经由大肠杆菌、黄色短杆菌、谷氨酸杆菌或钝齿棒杆菌为菌种经发酵精制得产品。

3.L-苏氨酸的工业生产方法主要有：①合成法；②发酵法；③蛋白质水解法三种。现提倡用发酵法生产。
发酵法是以糖、氨、高丝氨酸（homoserine）为培养基，用产谷氨酸小球菌（glutaminus）等发酵后精制可制得L- 苏氨酸。

4.提取法

5.注射液制法如下

6. 烟草：BU，22；FC，21；合成：可由蛋白质（如酪蛋白）经水解、精制而得，或由丙烯酸衍生物中甲醇和乙酸汞合成。

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L-苏氨酸海关

[ 海关编码 ]: 2922509090

[ 中文概述 ]:
2922509090. 其他氨基醇酚、氨基酸酚及其他含氧基氨基化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件：AB. 最惠国关税:6.5%. 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乙醇胺及其盐应报明色度, 乙醇胺及其盐应报明包装

[ 监管条件 ]: A.入境货物通关单 B.出境货物通关单

[ 检验检疫 ]: R.进口食品卫生监督检验 S.出口食品卫生监督检验

[ Summary ]:
2922509090. other amino-alcohol-phenols, amino-acid-phenols and other amino-compounds with oxygen function. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

L-苏氨酸文献

Urinary metabolic fingerprinting of mice with diet-induced metabolic derangements by parallel dual secondary column-dual detection two-dimensional comprehensive gas chromatography.

J. Chromatogr. A. 1361 , 265-76, (2014)

This study investigates the potential of a parallel dual secondary column-dual detection two-dimensional comprehensive GC platform (GC×2GC-MS/FID) for metabolic profiling and fingerprinting of mouse u...

Mechanism of chemical activation of sodium chloride in the presence of amino acids.

Food Chem. 166 , 301-8, (2014)

Sodium chloride has been shown to promote chlorination of glycerol during thermal processing. However, the detailed mechanism of this reaction is not well understood. Preliminary experiments have indi...

The unique serine/threonine phosphatase from the minimal bacterium Mycoplasma synoviae: biochemical characterization and metal dependence.

J. Biol. Inorg. Chem. 20(1) , 61-75, (2015)

Serine/threonine protein phosphatases have been described in many pathogenic bacteria as essential enzymes involved in phosphorylation-dependent signal transduction pathways and frequently associated ...

更多文献

L-苏氨酸

L-苏氨酸用途

L-苏氨酸名称

L-苏氨酸生物活性

L-苏氨酸物理化学性质

L-苏氨酸MSDS

详细MSDS(安全技术说明书)

L-苏氨酸毒性和生态

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

L-苏氨酸安全信息

L-苏氨酸合成路线

详细合成路线

L-苏氨酸上下游产品

L-苏氨酸上游产品

L-苏氨酸下游产品

L-苏氨酸制备

L-苏氨酸海关

L-苏氨酸文献

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