< 生产厂家价格 >

Psora-4

Psora-4用途

Psora-4是一种有效的选择性Kv1抑制剂。3(电压门控钾通道),EC50为3 nM【1】。Psora-4具有免疫抑制活性,并在体外抑制人和大鼠髓鞘特异性效应记忆T细胞的增殖[2]。

点击显示

Psora-4名称

[ CAS 号 ]:
724709-68-6

[ 英文名 ]:
Psora-4

[英文别名 ]:

Lopac-P-9872
5-(4-Phenylbutoxy)psoralen
Psora-4

Psora-4生物活性

[ 描述 ]:

[ 相关类别 ]:

研究领域 >> 炎症/免疫

信号通路 >> 跨膜转运 >> 钾通道

[参考文献]

[1]. Vennekamp J, et al. Kv1.3-blocking 5-phenylalkoxypsoralens: a new class of immunomodulators. Mol Pharmacol. 2004 Jun;65(6):1364-74.

Psora-4物理化学性质

[ 密度 ]:
1.246g/cm3

[ 沸点 ]:
537.7ºC at 760 mmHg

[ 分子式 ]:
C₂₁H₁₈O₄

[ 分子量 ]:
334.36500

[ 闪点 ]:
279ºC

[ 精确质量 ]:
334.12100

[ PSA ]:
52.58000

[ LogP ]:
4.94090

[ 外观性状 ]:
固体

[ 折射率 ]:
1.626

[ 储存条件 ]:
2-8°C，密封，干燥，避光

Psora-4安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H315-H319-H335-H413

[ 警示性声明 ]:
P261-P305 + P351 + P338

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
C

[ 危险品运输编码 ]:
NONH for all modes of transport

Psora-4文献

Psora-4, a Kv1.3 Blocker, Enhances Differentiation and Maturation in Neural Progenitor Cells.

CNS Neurosci. Ther. 21 , 558-67, (2015)

The self-repair ability of neural progenitor cells (NPCs) has been found to be activated and protected in several therapies helpful in multiple sclerosis (MS), an inflammatory demyelinating disease of...

K+ channels as targets for specific immunomodulation.

Trends Pharmacol. Sci. 25 , 280-289, (2004)

The voltage-gated Kv1.3 channel and the Ca(2+)-activated IKCa1 K(+) channel are expressed in T cells in a distinct pattern that depends on the state of lymphocyte activation and differentiation. The c...

Kv1.3-blocking 5-phenylalkoxypsoralens: a new class of immunomodulators.

Mol. Pharmacol. 65 , 1364-1374, (2004)

The lymphocyte potassium channel Kv1.3 is widely regarded as a promising new target for immunosuppression. To identify a potent small-molecule Kv1.3 blocker, we synthesized a series of 5-phenylalkoxyp...

更多文献