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喹乙宗

喹乙宗用途

喹唑酮是一种口服利尿剂,也是碳酸酐酶的弱抑制剂。喹唑酮可用于高血压研究[1][2]。

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喹乙宗名称

[ CAS 号 ]:
73-49-4

[ 中文名 ]:
喹噻酮

[ 英文名 ]:
Quinethazone

[中文别名 ]:

喹乙宗

[英文别名 ]:

Quimethazin
Quinethazonum
Hydromox
Quinetazona
Quinethazon
Chinethazonum
UNII:455E0S048W
quinethazone
Aquamox
Idrokin

喹乙宗生物活性

[ 描述 ]:

喹唑酮是一种口服利尿剂,也是碳酸酐酶的弱抑制剂。喹唑酮可用于高血压研究[1][2]。

[ 相关类别 ]:

研究领域 >> 心血管疾病

信号通路 >> 代谢酶/蛋白酶 >> 碳酸酐酶

[体内研究]

喹唑酮(50 mg/kg；p.o.；每日2周)降低肾性高血压大鼠的血压,与主动脉壁钾含量降低相关,但水或钠含量无变化[1]。动物模型：5-6周龄Long Evans雄性大鼠,高血压模型[1]剂量：50 mg/kg给药：口服,每日2周结果：对高血压大鼠动脉组织中的钠或水分布没有显著影响,但降低了约20%的细胞内钾含量

[参考文献]

[1]. FREED SC. MECHANISM OF ANTI-HYPERTENSIVE ACTION OF QUINETHAZONE. Proc Soc Exp Biol Med. 1963 Nov;114:421-2.

[2]. Angelopoulos B, et al. Experimental investigation and observations on the diuretic action of quinethazone. Med Pharmacol Exp Int J Exp Med. 1966;14(6):528-36.

喹乙宗物理化学性质

[ 密度 ]:
1.4±0.1 g/cm3

[ 熔点 ]:
250 - 252ºC

[ 分子式 ]:
C₁₀H₁₂ClN₃O₃S

[ 分子量 ]:
289.739

[ 精确质量 ]:
289.028778

[ PSA ]:
109.67000

[ LogP ]:
0.49

[ 外观性状 ]:
白色粉末

[ 折射率 ]:
1.582

喹乙宗毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: VA1679500

CHEMICAL NAME :: 6-Quinazolinesulfonamide, 1,2,3,4-tetrahydro-7-chloro-2-ethyl-4-oxo-

CAS REGISTRY NUMBER :: 73-49-4

BEILSTEIN REFERENCE NO. :: 0818554

LAST UPDATED :: 199612

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C10-H12-Cl-N3-O3-S

MOLECULAR WEIGHT :: 289.76

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >10 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,201,1982 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X5486 No. of Facilities: 16 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 94 (estimated) No. of Female Employees: 62 (estimated)