生长抑素 28

生长抑素 28用途

生长抑素-28(绵羊)是一种生物活性多肽,在近端肠上皮细胞中合成。生长抑素-28(绵羊)抑制葡萄糖刺激的胰岛素分泌,而不影响循环基础胰岛素浓度。生长抑素-28(绵羊)还靶向生长抑素受体亚型5(SSTR5),以调节GLP-1分泌[1][2]。

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生长抑素 28名称

[ CAS 号 ]:
73032-94-7

[ 中文名 ]:
促生长抑制素-28

[ 英文名 ]:
Somatostatin-28 trifluoroacetate salt

[中文别名 ]:

[英文别名 ]:

Somatostatin-28
Somatostatin 28,Cyclic
MFCD00076772
Somatostatin-28 (sheep) 28

生长抑素 28生物活性

[ 描述 ]:

[ 相关类别 ]:

信号通路 >> G 蛋白偶联受体/G 蛋白 >> 生长抑素受体

研究领域 >> 代谢疾病

[ 靶点 ]

SSTR5

[体外研究]

生长抑素-28剂量依赖地抑制胃泌素释放肽刺激的 GLP-1蛋白分泌,第50周为 0.01nM[1]

[体内研究]

生长抑素-28(绵羊)(1.1 pmol/kg/min；通过颈静脉导管静脉注射; 15分钟)抑制 25μg/kg/min葡萄糖诱导绵羊胰岛素分泌[2]。动物模型：Finn Dorset Horn杂交绵羊(2-5岁,70-75 kg)[2]剂量：1.1 pmol/kg/min,15分钟,含或不含25μg/kg/min葡萄糖；给药：经颈静脉导管静脉注射；结果：显著抑制胰岛素分泌,导致血清浓度从约200pmol/L降至150pmol/L。

[参考文献]

[1]. Martin PA, et al. Effects of somatostatin-28 on circulating concentrations of insulin and gut hormones in sheep. J Endocrinol. 1996 Oct;151(1):107-12.

[2]. Chisholm C, et al. Somatostatin-28 regulates GLP-1 secretion via somatostatin receptor subtype 5 in rat intestinal cultures. Am J Physiol Endocrinol Metab. 2002 Aug;283(2):E311-7.

生长抑素 28物理化学性质

[ 分子式 ]:
C₁₃₇H₂₀₇N₄₁O₃₉S₃

[ 分子量 ]:
3148.56000

[ 精确质量 ]:
3146.46000

[ PSA ]:
1392.71000

[ LogP ]:
0.20370

[ 储存条件 ]:
-20°C

生长抑素 28安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危害码 (欧洲) ]:
Xi

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

生长抑素 28文献

Somatostatin and its receptor family.

Front. Neuroendocrinol. 20 , 157-198, (1999)

Somatostatin (SST), a regulatory peptide, is produced by neuroendocrine, inflammatory, and immune cells in response to ions, nutrients, neuropeptides, neurotransmitters, thyroid and steroid hormones, ...

Somatostatin receptor subtype-5 mediates inhibition of peptide YY secretion from rat intestinal cultures.

Am. J. Physiol. 279 , G983-G989, (2000)

Somatostatin-14 (S-14) and somatostatin-28 (S-28) bind to five distinct membrane receptors (SSTRs), but S-28 has higher affinity for SSTR-5. Whether S-28 acting through SSTR-5 regulates inhibition of ...

Intracisternal injection of somatostatin receptor 5-preferring agonists induces a vagal cholinergic stimulation of gastric emptying in rats.

J. Pharmacol. Exp. Ther. 293 , 1099-1105, (2000)

We previously showed that the somatostatin receptor 5 (sst(5))-preferring agonist BIM-23052 injected intracisternally (i.c. ; 0.8 nmol/rat) stimulated gastric emptying of a non-nutrient meal in consci...

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