依匹普林

依匹普林用途

Epiroprim (Ro11-8958) 是一种选择性二氢叶酸还原酶 (DHFR) 抑制剂。Epiroprim 对葡萄球菌、肠球菌、肺炎球菌和链球菌表现出优异的活性。

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依匹普林名称

[ CAS 号 ]:
73090-70-7

[ 中文名 ]:
依匹普林

[ 英文名 ]:
EPIROPRIM

[英文别名 ]:

Ro 11-8958
Epiroprima [INN-Spanish]
Epiroprimum [INN-Latin]
Epiroprime [INN-French]
Epiroprim

依匹普林生物活性

[ 描述 ]:

Epiroprim (Ro11-8958) 是一种选择性二氢叶酸还原酶 (DHFR) 抑制剂。Epiroprim 对葡萄球菌、肠球菌、肺炎球菌和链球菌表现出优异的活性。

[ 相关类别 ]:

研究领域 >> 感染

信号通路 >> 抗感染 >> 细菌

[参考文献]

[1]. H H Locher, et al. Antibacterial activities of epiroprim, a new dihydrofolate reductase inhibitor, alone and in combination with dapsone. Antimicrob Agents Chemother. 1996 Jun;40(6):1376-81.

依匹普林物理化学性质

[ 密度 ]:
1.27g/cm3

[ 沸点 ]:
626.5ºC at 760 mmHg

[ 分子式 ]:
C₁₉H₂₃N₅O₂

[ 分子量 ]:
353.41800

[ 闪点 ]:
332.7ºC

[ 精确质量 ]:
353.18500

[ PSA ]:
101.21000

[ LogP ]:
3.98230

[ 折射率 ]:
1.629

依匹普林毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: UV8140650

CHEMICAL NAME :: 2,4-Pyrimidinediamine, 5-((3,5-diethoxy-4-(1H-pyrrol-1-yl)phenyl)methyl)-

CAS REGISTRY NUMBER :: 73090-70-7

LAST UPDATED :: 199612

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C19-H23-N5-O2

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1419 mg/kg

TOXIC EFFECTS :: Behavioral - tremor Behavioral - convulsions or effect on seizure threshold Behavioral - ataxia

REFERENCE :: JCHEEU Journal of Chemotherapy. (Edizioni Riviste Scientifiche, via R. Giuliani, 419, 50141 Florence, Italy) V.1- 1989- Volume(issue)/page/year: 5,400,1993

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 2 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JCHEEU Journal of Chemotherapy. (Edizioni Riviste Scientifiche, via R. Giuliani, 419, 50141 Florence, Italy) V.1- 1989- Volume(issue)/page/year: 5,400,1993