N-甲酰脱乙酰秋水仙碱

N-甲酰脱乙酰秋水仙碱名称

[ CAS 号 ]:
7411-12-3

[ 中文名 ]:
N-甲酰脱乙酰秋水仙碱

[ 英文名 ]:
Formamide,N-[(7S)-5,6,7,9-tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo[a]heptalen-7-yl]-

[英文别名 ]:

Formyldescaetylcolchicine,N
N-deacetyl-N-formylcolchicine
N-Formyldeacetylcolchicine
N-Desacetyl-N-formyl-colchicin
COLCHICINE,N-DEACETYL-N-FORMYL
Gloriosine
N-formyl-N-deacetylcolchicine
N-Formyldesacetylcolchicine

N-甲酰脱乙酰秋水仙碱物理化学性质

[ 密度 ]:
1.27g/cm3

[ 沸点 ]:
715.8ºC at 760 mmHg

[ 熔点 ]:
264-267ºC

[ 分子式 ]:
C₂₁H₂₃NO₆

[ 分子量 ]:
385.41000

[ 闪点 ]:
386.7ºC

[ 精确质量 ]:
385.15300

[ PSA ]:
83.09000

[ LogP ]:
3.50830

[ 折射率 ]:
1.591

N-甲酰脱乙酰秋水仙碱毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: GH0794000

CHEMICAL NAME :: Colchicine, N-deacetyl-N-formyl-

CAS REGISTRY NUMBER :: 7411-12-3

BEILSTEIN REFERENCE NO. :: 2824080

LAST UPDATED :: 199612

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C21-H23-N-O6

MOLECULAR WEIGHT :: 385.45

WISWESSER LINE NOTATION :: L B677 MV&T&J CO1 DO1 EO1 JMVH NO1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 2 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: HCACAV Helvetica Chimica Acta. (Verlag Helvetica Chimica Acta, Postfach, CH-4002 Basel, Switzerland) V.1- 1918- Volume(issue)/page/year: 33,1606,1950

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 4400 ug/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - muscle weakness Gastrointestinal - hypermotility, diarrhea

REFERENCE :: PHTXA6 Pharmacology and Toxicology. English translation of FATOAO. (New York, NY) V.20-22, 1957-59. Discontinued. Volume(issue)/page/year: 20,284,1957

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 2666 ug/kg

TOXIC EFFECTS :: Tumorigenic - active as anti-cancer agent

REFERENCE :: JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 24,636,1981

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 9200 ug/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - muscle weakness Gastrointestinal - hypermotility, diarrhea

REFERENCE :: PHTXA6 Pharmacology and Toxicology. English translation of FATOAO. (New York, NY) V.20-22, 1957-59. Discontinued. Volume(issue)/page/year: 20,284,1957

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N-甲酰脱乙酰秋水仙碱安全信息

[ 海关编码 ]:
2924299090

N-甲酰脱乙酰秋水仙碱合成路线

详细合成路线

N-甲酰脱乙酰秋水仙碱海关

[ 海关编码 ]: 2924299090

[ 中文概述 ]:
2924299090. 其他环酰胺（包括环氨基甲酸酯）（包括其衍生物以及他们的盐）. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 包装

[ Summary ]:
2924299090. other cyclic amides (including cyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%