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N-甲酰乙胺

N-甲酰乙胺名称

[ CAS 号 ]:
627-45-2

[ 中文名 ]:
N-甲酰乙胺

[ 英文名 ]:
N-Ethylformamide

[中文别名 ]:

N-乙基甲酰胺

[英文别名 ]:

EINECS 211-001-2
N-formylethylamine
monoethyl-formamide
Ethylformamide
MFCD00042672
N-ethyl carboxamide
N-ethyl-formamide
Formamide,N-ethyl
N-Aethylformamid [German]

N-甲酰乙胺物理化学性质

[ 密度 ]:
0.950 g/mL at 20ºC(lit.)

[ 沸点 ]:
202-204ºC

[ 熔点 ]:
-60.43°C (estimate)

[ 分子式 ]:
C₃H₇NO

[ 分子量 ]:
73.09380

[ 闪点 ]:
67ºC

[ 精确质量 ]:
73.05280

[ PSA ]:
29.10000

[ LogP ]:
0.77910

[ 外观性状 ]:
液体;Colorless to Light yellow to Light orange clear liquid

[ 折射率 ]:
n20/D 1.432

[ 储存条件 ]:
存放于惰性气体之中;避免空气

N-甲酰乙胺MSDS

N-甲酰乙胺毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: LQ2725000

CHEMICAL NAME :: Formamide, N-ethyl-

CAS REGISTRY NUMBER :: 627-45-2

BEILSTEIN REFERENCE NO. :: 1737860

LAST UPDATED :: 199701

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C3-H7-N-O

MOLECULAR WEIGHT :: 73.11

WISWESSER LINE NOTATION :: VHM2

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 3 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 18,645,1968

TYPE OF TEST :: LD - Lethal dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >1200 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: THERAP Therapie. (Doin, Editeurs, 8, Place de l'Odeon, F-75006 Paris, France) V.1- 1946- Volume(issue)/page/year: 27,873,1972

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N-甲酰乙胺安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xi

[ 安全声明 (欧洲) ]:
S23-S24/25

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ RTECS号 ]:
LQ2725000

[ 海关编码 ]:
2924199090

N-甲酰乙胺合成路线

N-甲酰乙胺上下游产品

N-甲酰乙胺上游产品

N-甲酰乙胺下游产品

N-甲酰乙胺海关

[ 海关编码 ]: 2924199090

[ 中文概述 ]:
2924199090. 其他无环酰胺（包括无环氨基甲酸酯)(包括其衍生物及盐）. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 包装

[ Summary ]:
2924199090. other acyclic amides (including acyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

N-甲酰乙胺文献

N-methylformamide: antitumour activity and metabolism in mice.

Br. J. Cancer 45(6) , 843-50, (1982)

The antitumour activities of N-methylformamide, N-ethylformamide and formamide against a number of murine tumours in vivo (Sarcoma 180, M5076 ovarian sarcoma and TLX5 lymphoma) have been estimated. In...

Cloning and expression of rat CYP2E1 in Saccharomyces cerevisiae: detection of genotoxicity of N-alkylformamides.

Environ. Mol. Mutagen. 36(2) , 97-104, (2000)

A cDNA coding for rat cytochrome P450 2E1 was cloned into the multicopy vector pYeDP60 and expressed in haploid RSY6 and diploid RS112 yeast strains of Saccharomyces cerevisiae under control of the GA...

An investigation of the relationship between the hepatotoxicity and the metabolism of N-alkylformamides.

J. Pharmacol. Exp. Ther. 240(1) , 265-70, (1987)

The hepatotoxicity and metabolism of the following close analogs of the hepatotoxic antitumor agent N-methylformamide (NMF) were investigated in CBA/CA mice: N-ethylformamide (NEF), dimethylformamide ...

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