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原水仙碱

原水仙碱名称

[ CAS 号 ]:
477-27-0

[ 中文名 ]:
原秋水仙碱

[ 英文名 ]:
Colchiceine

[中文别名 ]:

[英文别名 ]:

colchiceine

原水仙碱物理化学性质

[ 密度 ]:
1.31g/cm3

[ 沸点 ]:
731.5ºC at 760mmHg

[ 熔点 ]:
172-174ºC

[ 分子式 ]:
C₂₁H₂₃NO₆

[ 分子量 ]:
385.41000

[ 闪点 ]:
396.2ºC

[ 精确质量 ]:
385.15300

[ PSA ]:
94.09000

[ LogP ]:
2.95950

[ 蒸汽压 ]:
1.83E-22mmHg at 25°C

[ 折射率 ]:
1.61

[ 储存条件 ]:
库房通风低温干燥

原水仙碱毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: GH0520000

CHEMICAL NAME :: Colchiceine

CAS REGISTRY NUMBER :: 477-27-0

BEILSTEIN REFERENCE NO. :: 2824078

LAST UPDATED :: 199612

DATA ITEMS CITED :: 10

MOLECULAR FORMULA :: C21-H23-N-O6

MOLECULAR WEIGHT :: 385.45

WISWESSER LINE NOTATION :: L B677 MV&T&J CO1 DO1 EO1 JMV1 NQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Human

DOSE/DURATION :: 43 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 75 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 2500 ug/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - muscle weakness Gastrointestinal - hypermotility, diarrhea

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 30 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 84 mg/kg

TOXIC EFFECTS :: Blood - hemorrhage

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: Mutation test systems - not otherwise specified

TYPE OF TEST :: Mutation test systems - not otherwise specified

TYPE OF TEST :: Sperm Morphology

MUTATION DATA

TYPE OF TEST :: Mutation test systems - not otherwise specified

TEST SYSTEM :: Rodent - hamster Ovary

DOSE/DURATION :: 250 nmol/L

REFERENCE :: AJPAA4 American Journal of Pathology. (Lippincott/Harper, Journal Fulfillment Dept., 2350 Virginia Ave., Hagerstown, MD 21740) V.1- 1925- Volume(issue)/page/year: 137,779,1990

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原水仙碱安全信息

[ 危害码 (欧洲) ]:
T+

[ 海关编码 ]:
2924299090

原水仙碱合成路线

详细合成路线

原水仙碱上下游产品

原水仙碱上游产品

原水仙碱下游产品

原水仙碱海关

[ 海关编码 ]: 2924299090

[ 中文概述 ]:
2924299090. 其他环酰胺（包括环氨基甲酸酯）（包括其衍生物以及他们的盐）. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 包装

[ Summary ]:
2924299090. other cyclic amides (including cyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%