1,3-二硝基芘
1,3-二硝基芘名称
[ CAS 号 ]:
75321-20-9
[ 中文名 ]:
1,3-二硝基芘
[ 英文名 ]:
1,3-Dinitropyrene
[中文别名 ]:
[英文别名 ]:
- MFCD00010493
- 1,3-dinitropyrene
1,3-二硝基芘物理化学性质
[ 密度 ]:
1.574g/cm3
[ 沸点 ]:
493.9ºC at 760 mmHg
[ 分子式 ]:
C16H8N2O4
[ 分子量 ]:
292.24600
[ 闪点 ]:
248ºC
[ 精确质量 ]:
292.04800
[ PSA ]:
91.64000
[ LogP ]:
5.44680
[ 折射率 ]:
1.887
1,3-二硝基芘毒性和生态
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- UR2454000
- CHEMICAL NAME :
- Pyrene, 1,3-dinitro-
- CAS REGISTRY NUMBER :
- 75321-20-9
- LAST UPDATED :
- 199806
- DATA ITEMS CITED :
- 26
- MOLECULAR FORMULA :
- C16-H8-N2-O4
- MOLECULAR WEIGHT :
- 292.26
- WISWESSER LINE NOTATION :
- L666 B6 2AB PJ DNW FNW
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 23 mg/kg/4W-I
- TOXIC EFFECTS :
- Tumorigenic - Carcinogenic by RTECS criteria Skin and Appendages - tumors
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 16 mg/kg/10W-I
- TOXIC EFFECTS :
- Tumorigenic - Carcinogenic by RTECS criteria Tumorigenic - tumors at site of application
- TYPE OF TEST :
- TD - Toxic dose (other than lowest)
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 35071 ug/kg/4W-I
- TOXIC EFFECTS :
- Tumorigenic - equivocal tumorigenic agent by RTECS criteria Skin and Appendages - tumors
MUTATION DATA
- TYPE OF TEST :
- Mutation in mammalian somatic cells
- TEST SYSTEM :
- Rodent - hamster Ovary
- DOSE/DURATION :
- 500 ug/L
- REFERENCE :
- MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 119,387,1983 *** REVIEWS *** IARC Cancer Review:Animal Limited Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 46,201,1989 IARC Cancer Review:Human No Adequate Data IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 46,201,1989 IARC Cancer Review:Group 3 IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 46,201,1989
1,3-二硝基芘安全信息
[ 符号 ]:
GHS07
[ 信号词 ]:
Warning
[ 危害声明 ]:
H302 + H312 + H332
[ 警示性声明 ]:
P280
[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves
[ 危害码 (欧洲) ]:
Xn: Harmful;
[ 风险声明 (欧洲) ]:
20/21/22
[ 危险品运输编码 ]:
NONH for all modes of transport
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1,3-二硝基芘文献
Cancer Res. 50(7) , 2036-43, (1990)
NADPH-fortified human liver microsomes were examined with regard to ability to detoxicate several chemicals that do not require enzymatic oxidation to elicit a genotoxic response in a Salmonella typhi...
Modulation of the mutagenicity of three dinitropyrene isomers in vitro by rat-liver S9, cytosolic, and microsomal fractions following chronic ethanol ingestion.Mutat. Res. 279(4) , 289-98, (1992)
The effects of chronic ethanol feeding of rats on the ability of liver fractions to modulate the bacterial mutagenicity of three dinitropyrene isomers (1,3-, 1,6- and 1,8-DNP), which require bacterial...
Mutagenic activity and quantification of nitroarenes in surface soil in the Kinki region of Japan.Mutat. Res. 538(1-2) , 121-31, (2003)
To clarify the mutagenic potential of surface soil in the Kinki region of Japan, particularly in Osaka and neighboring cities, 62 surface soil samples were collected and their organic extracts were ex...
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