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α-Conotoxin GI

α-Conotoxin GI用途

α-锥虫毒素GI对nAChR具有很高的亲和力。

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α-Conotoxin GI名称

[ CAS 号 ]:
76862-65-2

[ 中文名 ]:
GLU-CYS-CYS-ASN-PRO-ALA-CYS-GLY-ARG-HIS-TYR-SER-CYS-NH2

[ 英文名 ]:
α-Conotoxin GI

[中文别名 ]:

芋螺毒素 G I

[英文别名 ]:

a-Conotoxin GI
CONOTOXIN GI
a-Conotoxin GI,Conus geographus

α-Conotoxin GI生物活性

[ 描述 ]:

α-锥虫毒素GI对nAChR具有很高的亲和力。

[ 相关类别 ]:

信号通路 >> 跨膜转运 >> 胆碱受体

信号通路 >> 神经信号通路 >> 胆碱受体

研究领域 >> 神经疾病

[参考文献]

[1]. Groebe DR, et al. Determinants involved in the affinity of alpha-conotoxins GI and SI for the muscle subtype of nicotinic acetylcholine receptors. Biochemistry. 1997 May 27;36(21):6469-74.

[2]. Yu S, et al. Sensitive Detection of α-Conotoxin GI in Human Plasma Using a Solid-Phase Extraction Column and LC-MS/MS. Toxins (Basel). 2017 Jul 28;9(8):235.

[3]. Blount K, et al. alpha-Conotoxin GI produces tetanic fade at the rat neuromuscular junction. Toxicon. 1992 Aug;30(8):835-42.

α-Conotoxin GI物理化学性质

[ 密度 ]:
1.71

[ 分子式 ]:
C₅₅H₈₀N₂₀O₁₈S₄

[ 分子量 ]:
1437.61

[ 精确质量 ]:
1436.48000

[ PSA ]:
722.15000

[ 储存条件 ]:
-20°C

α-Conotoxin GIMSDS

详细MSDS(安全技术说明书)

α-Conotoxin GI毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: GL1500000

CHEMICAL NAME :: Conotoxin GI

CAS REGISTRY NUMBER :: 76862-65-2

LAST UPDATED :: 199506

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C55-H80-N20-O18-S4

MOLECULAR WEIGHT :: 1437.79

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 12 ug/kg

TOXIC EFFECTS :: Peripheral Nerve and Sensation - flaccid paralysis without anesthesia (usually neuromuscular blockage) Lungs, Thorax, or Respiration - other changes

REFERENCE :: ABBIA4 Archives of Biochemistry and Biophysics. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.31- 1951- Volume(issue)/page/year: 190,539,1978

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α-Conotoxin GI安全信息

[ 危害码 (欧洲) ]:
Xn

[ 危险品运输编码 ]:
UN 3172

[ 包装等级 ]:
III

[ 危险类别 ]:
6.1(b)