三(羟甲基)氨基甲烷

Trometamol 是一种低毒性的生物惰性氨基醇,可以在体内和体外缓冲二氧化碳和酸。Trometamol 是一种在生理范围内控制 pH 值的有效胺类化合物。

[ 描述 ]:

[ 相关类别 ]:

[参考文献]

[ 密度 ]:
1.3±0.1 g/cm3

[ 沸点 ]:
357.0±37.0 °C at 760 mmHg

[ 熔点 ]:
167-172 °C(lit.)

[ 分子式 ]:
C₄H₁₁NO₃

[ 分子量 ]:
121.135

[ 闪点 ]:
169.7±26.5 °C

[ 精确质量 ]:
121.073891

[ PSA ]:
86.71000

[ LogP ]:
-1.38

[ 外观性状 ]:
白色结晶粉末

[ 蒸汽压 ]:
0.0±1.8 mmHg at 25°C

[ 折射率 ]:
1.544

[ 储存条件 ]:
2-8°C

[ 稳定性 ]:
Stable. Incompatible with bases, strong oxidizing agents. Protect from moisture.

[ 水溶解性 ]:
550 g/L (25 ºC)

详细MSDS(安全技术说明书)

CHEMICAL IDENTIFICATION

RTECS NUMBER :

TY2900000

CHEMICAL NAME :

1,3-Propanediol, 2-amino-2-(hydroxymethyl)-

CAS REGISTRY NUMBER :

77-86-1

LAST UPDATED :

199706

DATA ITEMS CITED :

7

MOLECULAR FORMULA :

C4-H11-N-O3

MOLECULAR WEIGHT :

121.16

WISWESSER LINE NOTATION :

Q1XZ1Q1Q

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

5900 mg/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

REFERENCE :

BCFAAI Bollettino Chimico Farmaceutico. (Societa Editoriale Farmaceutica, Via Ausonio 12, 20123 Milan, Italy) V.33- 1894- Volume(issue)/page/year: 110,653,1971

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Intravenous

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

1800 mg/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

REFERENCE :

NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: -,419,1990

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Intravenous

SPECIES OBSERVED :

Rodent - mouse

DOSE/DURATION :

1210 mg/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

REFERENCE :

ABMGAJ Acta Biologica et Medica Germanica. (Berlin, Ger. Dem. Rep.) V.1-41, 1958-82. For publisher information, see BBIADT. Volume(issue)/page/year: 17,217,1966

TYPE OF TEST :

LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Rodent - rabbit

DOSE/DURATION :

1 gm/kg

TOXIC EFFECTS :

Behavioral - somnolence (general depressed activity) Behavioral - muscle weakness Behavioral - coma

REFERENCE :

JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA) V.18-31, 1936-49. For publisher information, see AEHLAU. Volume(issue)/page/year: 22,315,1940 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 81165 No. of Facilities: 850 (estimated) No. of Industries: 4 No. of Occupations: 6 No. of Employees: 7274 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 81165 No. of Facilities: 2296 (estimated) No. of Industries: 9 No. of Occupations: 22 No. of Employees: 40897 (estimated) No. of Female Employees: 30773 (estimated)

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xi:Irritant

[ 风险声明 (欧洲) ]:
R36/37/38

[ 安全声明 (欧洲) ]:
S26-S36-S37/39

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
2

[ RTECS号 ]:
TY2900000

[ 海关编码 ]:
29221980

详细合成路线

三(羟甲基)氨基甲烷上游产品

三(羟甲基)氨基甲烷下游产品

1.用相应的硝基化合物还原或催化氢化方法制取。

2.可用硝基甲烷与3mol甲醛作用生成三羟甲基硝基甲烷，再还原成三羟甲基氨基甲烷。

[ 海关编码 ]: 2922199090

[ 中文概述 ]:
2922199090. 其他氨基醇及其醚，酯和它们的盐（但含一种以上含氧基的除外）. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乙醇胺及其盐应报明色度, 乙醇胺及其盐应报明包装

[ Summary ]:
2922199090. other amino-alcohols, other than those containing more than one kind of oxygen function, their ethers and esters; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

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更多文献

公司名：上海化源世纪贸易有限公司

区域：上海市普陀区

价格：

联系人：徐经理

产品详情：三(羟甲基)氨基甲烷

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公司名：南通润丰石油化工有限公司

区域：南通市崇川区

价格：
￥需询单/1kg ￥需询单/1ton

联系人：曹经理

产品详情：三羟甲基氨基甲烷

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公司名：上海吉至生化科技有限公司

区域：上海市奉贤区

价格：
￥6788.0/25kg ￥1688.0/5kg ￥218.0/500g

联系人：刘佳

产品详情：三(羟甲基)氨基甲烷

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公司名：上海脉铂医药科技有限公司

区域：上海市嘉定区

价格：
￥589.0/1g ￥669.0/50mg ￥需询单/1g ￥需询单/1g

联系人：李先生

产品详情：Trometamol

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公司名：上海阿拉丁生化科技股份有限公司

区域：上海市浦东新区

价格：
￥119.9/100g ￥597.9/1kg ￥331.9/500g ￥2059.9/5kg

联系人：阿拉丁

产品详情：三（羟甲基）氨基甲烷

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