柠檬酸三丁酯

柠檬酸三丁酯用途

柠檬酸三丁酯是一种柠檬酸酯。柠檬酸三丁酯可用作赋形剂,如增塑剂。药用辅料,或称药用辅料,是指除药物成分外,在制药过程中使用的其他化学物质。药用辅料一般是指药物制剂中的非活性成分,可以提高药物制剂的稳定性、溶解性和加工性。药用辅料也会影响联合给药药物的吸收、分布、代谢和消除(ADME)过程[1][2]。

柠檬酸三丁酯名称

[ CAS 号 ]:
77-94-1

[ 中文名 ]:
柠檬酸三丁酯

[ 英文名 ]:
Tributyl citrate

[中文别名 ]:

[英文别名 ]:

Tri-n-butyl citrate
Citric acid tri-n-butyl ester
EINECS 201-071-2
MFCD00027217
Citric acid, tributyl ester (8CI)
Tributyl citrate
tributyl 2-hydroxypropane-1,2,3-tricarboxylate

柠檬酸三丁酯生物活性

[ 描述 ]:

[ 相关类别 ]:

研究领域 >> 其他

信号通路 >> 其他 >> 其他

[参考文献]

[1]. FINKELSTEIN M, et al. Toxicology of the citric acid esters: tributyl citrate, acetyl tributyl citrate, triethyl citrate, and acetyl triethyl citrate. Toxicol Appl Pharmacol. 1959 May;1(3):283-98.

[2]. Elder DP, et al. Pharmaceutical excipients - quality, regulatory and biopharmaceutical considerations. Eur J Pharm Sci. 2016 May 25;87:88-99.

柠檬酸三丁酯物理化学性质

[ 密度 ]:
1.1±0.1 g/cm3

[ 沸点 ]:
389.8±9.0 °C at 760 mmHg

[ 熔点 ]:
≥300 °C(lit.)

[ 分子式 ]:
C₁₈H₃₂O₇

[ 分子量 ]:
360.45

[ 闪点 ]:
120.7±12.2 °C

[ 精确质量 ]:
360.214813

[ PSA ]:
99.13000

[ LogP ]:
4.68

[ 蒸汽压 ]:
0.0±2.0 mmHg at 25°C

[ 折射率 ]:
1.465

[ 储存条件 ]:
室温，密封

[ 水溶解性 ]:
insoluble

柠檬酸三丁酯MSDS

柠檬酸三丁酯毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: TZ8608000

CHEMICAL NAME :: 1,2,3-Propanetricarboxylic acid, 2-hydroxy-, tributyl ester

CAS REGISTRY NUMBER :: 77-94-1

BEILSTEIN REFERENCE NO. :: 1806072

LAST UPDATED :: 199701

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C18-H32-O7

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 2900 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Vascular - other changes

REFERENCE :: JPMSAE Journal of Pharmaceutical Sciences. (American Pharmaceutical Assoc., 2215 Constitution Ave., NW, Washington, DC 20037) V.50- 1961- Volume(issue)/page/year: 53,774,1964 ** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 8120 mg/kg/14D-I

TOXIC EFFECTS :: Nutritional and Gross Metabolic - weight loss or decreased weight gain

REFERENCE :: JPMSAE Journal of Pharmaceutical Sciences. (American Pharmaceutical Assoc., 2215 Constitution Ave., NW, Washington, DC 20037) V.50- 1961- Volume(issue)/page/year: 53,774,1964

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柠檬酸三丁酯安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves

[ 危害码 (欧洲) ]:
T: Toxic;

[ 风险声明 (欧洲) ]:
R25

[ 安全声明 (欧洲) ]:
S26-S36/37/39-S45-S24/25

[ 危险品运输编码 ]:
UN 2811 6.1/PG 2

[ WGK德国 ]:
3

[ RTECS号 ]:
TZ8608000

[ 海关编码 ]:
2918150000

柠檬酸三丁酯合成路线

柠檬酸三丁酯上下游产品

柠檬酸三丁酯上游产品

柠檬酸三丁酯下游产品

柠檬酸三丁酯制备

1.柠檬酸和正丁醇(投料比1∶1)在硫酸(投料量为柠檬酸和正丁醇总质量的0.3%)的作用下，于150℃回流4～5h，当反应物的酸值降至1mgKOH/g以下时，即为酯化终点。产物经活性炭脱色、过滤、中和、水洗、减压蒸馏，釜液即为成品。

精制方法：含有游离的酸和醇等杂质。精制时用无水碳酸钾或硫酸钠干燥后减压精馏。

2.制法：

于1L圆底烧瓶中加入柠檬酸（2）315g（1.0mol），正丁醇500g（6.7mol），1.5mL浓硫酸。装上60cm的分馏柱和分水器，加热反应脱水，约4h脱水115～120mL，反应液温度达到130℃。继续加热至反应液温度155℃，并回收丁醇。而后冷至50℃，分批加入固体碳酸钠4g，中和硫酸，直至pH5～6。放置过夜，过滤，减压蒸馏，收集198～200℃/0.8～0.9kPa的馏分，得产品（1）460g，收率85%。

柠檬酸三丁酯海关

[ 海关编码 ]: 2918150000

[ 中文概述 ]:
2918150000. 柠檬酸盐和柠檬酸酯. 增值税率:17.0%. 退税率:13.0%. 监管条件:4ABxy(出口许可证,入境货物通关单,出境货物通关单出口许可证(加工贸易),出口许可证(边境小额贸易)). 最惠国关税:6.5%. 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ 监管条件 ]: 4.出口许可证 A.入境货物通关单 B.出境货物通关单 x.出口许可证(加工贸易) y.出口许可证(边境小额贸易)

[ 检验检疫 ]: R.进口食品卫生监督检验 S.出口食品卫生监督检验 N.出口商品检验

[ Summary ]:
2918150000. other salts and esters of citric acid. VAT:17.0%. Tax rebate rate:13.0%. Supervision conditions:4ABXY(export license,certificate of inspection for goods inward,certificate of inspection for goods outwardexport license(processing trade),export license(border small volume trade)). MFN tariff:6.5%. General tariff:30.0%

柠檬酸三丁酯文献

Formulation considerations in the design of topical, polymeric film-forming systems for sustained drug delivery to the skin.

Eur. J. Pharm. Biopharm. 91 , 9-15, (2015)

Polymeric film-forming systems (FFSs) are potential drug delivery systems for topical application to the skin. The FFSs form thin and transparent polymeric films in situ upon solvent evaporation. Thei...

Improved mechanical property and water resistance of zein films by plasticization with tributyl citrate.

J. Agric. Food Chem. 60(23) , 5988-93, (2012)

Pure zein film is intrinsically rigid and brittle and lacks necessary mechanical properties for industrial processing. In addition, pure zein film is sensitive to high relative humidity, which limits ...

Development of sustained-release lipophilic calcium stearate pellets via hot melt extrusion.

Eur. J. Pharm. Biopharm. 79(3) , 635-45, (2011)

The objective of this study was the development of retarded release pellets using vegetable calcium stearate (CaSt) as a thermoplastic excipient. The matrix carrier was hot melt extruded and pelletize...

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