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去乙基利多卡因

去乙基利多卡因用途

单乙基甘氨酰亚胺是利多卡因(HY-B0185)的代谢产物,通过肝脏细胞色素P-450酶对木质素进行氧化N-脱乙基[1]。

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去乙基利多卡因名称

[ CAS 号 ]:
7728-40-7

[ 中文名 ]:
去乙基利多卡因

[ 英文名 ]:
Monoethylglycinexylidide

[中文别名 ]:

盐酸单乙基甘氨酸二甲基苯胺

[英文别名 ]:

monoethylglycine-2,6-xylidide
monoethyl glycine xylidide
MEGX
N-Ethylglycinexylidide
ethylaminoacet-2,6-xylidide
L 86
Ethylglycylxylidide
desmethyllidocaine
2-ethylamino-2',6'-dimethylacetanilide
Norlidocaine

去乙基利多卡因生物活性

[ 描述 ]:

单乙基甘氨酰亚胺是利多卡因(HY-B0185)的代谢产物,通过肝脏细胞色素P-450酶对木质素进行氧化N-脱乙基[1]。

[ 相关类别 ]:

研究领域 >> 炎症/免疫

研究领域 >> 代谢疾病

[参考文献]

[1]. Y S Huang, et al. Measuring lidocaine metabolite--monoethylglycinexylidide as a quantitative index of hepatic function in adults with chronic hepatitis and cirrhosis. J Hepatol. 1993 Aug;19(1):140-7.

去乙基利多卡因物理化学性质

[ 密度 ]:
1.047g/cm3

[ 沸点 ]:
335.6ºC at 760 mmHg

[ 熔点 ]:
242-245ºC

[ 分子式 ]:
C₁₂H₁₈N₂O

[ 分子量 ]:
206.28

[ 闪点 ]:
127.8ºC

[ 精确质量 ]:
206.14200

[ PSA ]:
41.13000

[ LogP ]:
2.31530

[ 外观性状 ]:
固体

[ 折射率 ]:
1.553

[ 储存条件 ]:
2-8°C

去乙基利多卡因MSDS

去乙基利多卡因毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: AN7740000

CHEMICAL NAME :: 2',6'-Acetoxylidide, 2-(ethylamino)-

CAS REGISTRY NUMBER :: 7728-40-7

BEILSTEIN REFERENCE NO. :: 2417108

LAST UPDATED :: 199612

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C12-H18-N2-O

MOLECULAR WEIGHT :: 206.32

WISWESSER LINE NOTATION :: 2M1MVR B1 F1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 234 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 179,580,1971

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去乙基利多卡因安全信息

[ 符号 ]:

GHS06

[ 信号词 ]:
Danger

[ 危害声明 ]:
H301

[ 警示性声明 ]:
P301 + P310

[ 危险品运输编码 ]:
UN 2811 6.1 / PGIII

[ RTECS号 ]:
AN7740000

[ 海关编码 ]:
2924299090

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去乙基利多卡因海关

[ 海关编码 ]: 2924299090

[ 中文概述 ]:
2924299090. 其他环酰胺（包括环氨基甲酸酯）（包括其衍生物以及他们的盐）. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 包装

[ Summary ]:
2924299090. other cyclic amides (including cyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

去乙基利多卡因文献

Transplacental Distribution of Lidocaine and Its Metabolite in Peridural Anesthesia Administered to Patients With Gestational Diabetes Mellitus.

Reprod. Sci. 22 , 791-7, (2015)

Neonatal effects of drugs administered to mothers before delivery depend on the quantity that crosses the placental barrier, which is determined by the pharmacokinetics of the drug in the mother, fetu...

Concentrations of dimethylaniline and other metabolites in milk and tissues of dairy cows treated with lidocaine.

Food Addit. Contam. Part A. Chem. Anal. Control. Expo. Risk Assess. 32 , 1256-64, (2015)

Lidocaine is a topical anaesthetic drug used in dairy cows for laparotomy (caesarean section, abomasal displacement). Because there are no registered drugs for this indication, it can be applied under...

MEGX test in hepatology: the long-sought ultimate quantitative liver function test?

J. Hepatol. 19(1) , 4-7, (1993)

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