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6-氟-DL-色氨酸

6-氟-DL-色氨酸用途

6-氟色氨酸是色氨酸羟化酶的竞争性抑制剂,在长期植入脑电图记录电极的大鼠中产生短暂的睡眠中断[1]。

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6-氟-DL-色氨酸名称

[ CAS 号 ]:
7730-20-3

[ 中文名 ]:
6-氟-DL-色氨酸

[ 英文名 ]:
UNII:3I7LZ8M32B

[英文别名 ]:

EINECS 231-788-6
Tryptophan, 6-fluoro-
2-Amino-3-(6-fluoro-1H-indol-3-yl)propanoic acid
6-Fluorotryptophan
6-fluoro-dl-tryptophan
MFCD00005653
UNII:3I7LZ8M32B

6-氟-DL-色氨酸生物活性

[ 描述 ]:

6-氟色氨酸是色氨酸羟化酶的竞争性抑制剂,在长期植入脑电图记录电极的大鼠中产生短暂的睡眠中断[1]。

[ 相关类别 ]:

信号通路 >> 代谢酶/蛋白酶 >> 色氨酸羟化酶

研究领域 >> 神经疾病

[参考文献]

[1]. Miwa S, et al. Determination of serotonin turnover in the rat brain using 6-fluorotryptophan. J Neurochem. 1987 May;48(5):1577-80.

[2]. D Sugden, et al. Changes in the rat sleep-wake cycle produced by DL-6-fluorotryptophan, a competitive inhibitor of tryptophan hydroxylase. Psychopharmacology (Berl). 1981;74(4):369-73.

6-氟-DL-色氨酸物理化学性质

[ 密度 ]:
1.4±0.1 g/cm3

[ 沸点 ]:
450.7±45.0 °C at 760 mmHg

[ 熔点 ]:
280-285 °C (dec.)(lit.)

[ 分子式 ]:
C₁₁H₁₁FN₂O₂

[ 分子量 ]:
222.216

[ 闪点 ]:
226.4±28.7 °C

[ 精确质量 ]:
222.080460

[ PSA ]:
79.11000

[ LogP ]:
1.09

[ 外观性状 ]:
灰白色粉末

[ 蒸汽压 ]:
0.0±1.2 mmHg at 25°C

[ 折射率 ]:
1.673

[ 储存条件 ]:
−20°C

6-氟-DL-色氨酸MSDS

详细MSDS(安全技术说明书)

6-氟-DL-色氨酸毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: YN6850000

CHEMICAL NAME :: DL-Tryptophan, 6-fluoro-

CAS REGISTRY NUMBER :: 7730-20-3

LAST UPDATED :: 199612

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C11-H11-F-N2-O2

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >1 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: BCPCA6 Biochemical Pharmacology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1958- Volume(issue)/page/year: 15,2134,1966

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6-氟-DL-色氨酸安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危害码 (欧洲) ]:
T

[ 安全声明 (欧洲) ]:
S24/25

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ RTECS号 ]:
YN6850000

[ 海关编码 ]:
2933990090

6-氟-DL-色氨酸上下游产品

6-氟-DL-色氨酸上游产品

6-氟-DL-色氨酸下游产品

6-氟-DL-色氨酸海关

[ 海关编码 ]: 2933990090

[ 中文概述 ]:
2933990090. 其他仅含氮杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

6-氟-DL-色氨酸文献

Substrate promiscuity of the cyclic dipeptide prenyltransferases from Aspergillus fumigatus ( section sign).

J. Nat. Prod. 72 , 44-52, (2009)

This study reports that a series of tryptophan derivatives with modifications on the side chain or at the indole ring were accepted by two cyclic dipeptide prenyltransferases, CdpNPT and FtmPT1, and c...

Cloning of the trp gene cluster from a tryptophan-hyperproducing strain of Corynebacterium glutamicum: identification of a mutation in the trp leader sequence.

Appl. Environ. Microbiol. 59(3) , 791-9, (1993)

Corynebacterium glutamicum ATCC 21850 produces up to 5 g of extracellular L-tryptophan per liter in broth culture and displays resistance to several synthetic analogs of aromatic amino acids. Here we ...

Atomic mutations at the single tryptophan residue of human recombinant annexin V: effects on structure, stability, and activity.

Biochemistry 38(33) , 10649-59, (1999)

The single tryptophan residue (Trp187) of human recombinant annexin V, containing 320 residues and 5328 atoms, was replaced with three different isosteric analogues where hydrogen atoms at positions 4...

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