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(D(CH2)51,TYR(ME)2,ORN8)-OXYTOCIN

(D(CH2)51,TYR(ME)2,ORN8)-OXYTOCIN用途

(d(CH2)51,Tyr(Me)2,Orn8)-Oxytocin (OVT) 是一种催产素受体拮抗剂。(d(CH2)51,Tyr(Me)2,Orn8)-Oxytocin 可用于神经系统疾病的研究。

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(D(CH2)51,TYR(ME)2,ORN8)-OXYTOCIN名称

[ CAS 号 ]:
77327-45-8

[ 中文名 ]:
(D(CH2)51,TYR(ME)2,ORN8)-OXYTOCIN

[ 英文名 ]:
(d(CH2)51,Tyr(Me)2,Orn8)-Oxytocin trifluoroacetate salt

[英文别名 ]:

[D(CH2)51,TYR(ME)2,ORN8]-VASOTOCIN
(D(CH2)(5/1),TYR(ME)2,ORN8)-OXYTOCIN
PMP-TYR(ME)-ILE-GLN-ASN-CYS-PRO-ORN-GLY-NH2
(D(CH2)51,(METHYL)TYR2,ORN8)-OXYTOCIN
me)(2)-orn(8)

(D(CH2)51,TYR(ME)2,ORN8)-OXYTOCIN生物活性

[ 描述 ]:

(d(CH2)51,Tyr(Me)2,Orn8)-Oxytocin (OVT) 是一种催产素受体拮抗剂。(d(CH2)51,Tyr(Me)2,Orn8)-Oxytocin 可用于神经系统疾病的研究。

[ 相关类别 ]:

信号通路 >> G 蛋白偶联受体/G 蛋白 >> 催产素受体

研究领域 >> 神经疾病

[参考文献]

[1]. Mullis K, et al. Oxytocin action in the ventral tegmental area affects sucrose intake. Brain Res. 2013 Jun 4;1513:85-91.

(D(CH2)51,TYR(ME)2,ORN8)-OXYTOCIN物理化学性质

[ 密度 ]:
1.4±0.1 g/cm3

[ 沸点 ]:
1537.6±65.0 °C at 760 mmHg

[ 分子式 ]:
C₄₈H₇₄N₁₂O₁₂S₂

[ 分子量 ]:
1075.304

[ 闪点 ]:
883.7±34.3 °C

[ 精确质量 ]:
1074.499023

[ PSA ]:
439.13000

[ LogP ]:
-2.55

[ 蒸汽压 ]:
0.0±0.3 mmHg at 25°C

[ 折射率 ]:
1.625

(D(CH2)51,TYR(ME)2,ORN8)-OXYTOCINMSDS

详细MSDS(安全技术说明书)

(D(CH2)51,TYR(ME)2,ORN8)-OXYTOCIN安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 安全声明 (欧洲) ]:
22-24/25

[ 危险品运输编码 ]:
NONH for all modes of transport

(D(CH2)51,TYR(ME)2,ORN8)-OXYTOCIN文献

Oxytocin enhances, and oxytocin antagonism decreases, sexual receptivity in intact female rats.

Neuropeptides 27(4) , 245-50, (1994)

In intact, non-ovariectomized female rats in spontaneous behavioral estrus, the i.c.v. injection of oxytocin significantly increased lordosis quotient and lordosis duration, starting from a dose of 1 ...

Effect of oxytocin receptor antagonists on the renal actions of oxytocin and vasopressin in the rat.

J. Endocrinol. 152(2) , 257-64, (1997)

The effect of three oxytocin receptor antagonists on the renal actions of oxytocin and vasopressin was investigated in conscious male rats infused with hypotonic saline. Infusion of oxytocin at 100 pg...

The oxytocin antagonist d(CH2)5Tyr(Me)2-Orn8-vasotocin reduces non-contact penile erections in male rats.

Neurosci. Lett. 265(3) , 171-4, (1999)

Male rats show four to six penile erection episodes when put for 80 min in the presence of an inaccessible receptive female. These non-contact penile erections were reduced dose-dependently by d(CH2)5...

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