N-甲基乙酰胺
N-甲基乙酰胺用途
1. 因它具有溶解其它有机物的优良性能所以在有机合成上常用作溶剂使用，在制药工业上使用较广泛，如合成头孢菌素，就使用它和为溶剂。 N-甲基乙酰胺对于某些化学反应有催化作用，在非极性溶剂中又是一个脱酸剂，所以目前使用广泛。
2. 用作农药中间体。
N-甲基乙酰胺名称
[ CAS 号 ]:
79-16-3
[ 中文名 ]:
N-甲基乙酰胺
[ 英文名 ]:
N-Methylacetamide
[中文别名 ]:
[英文别名 ]:
- Acetamide, N-methyl-
- Acetamide,methyl
- N-Monomethylacetamide
- N-Methyl acetamide
- Acetylmethylamine
- Acetamide,N-methyl
- N-acetyl-methylamine
- EINECS 201-182-6
- N-Acetylmethylamine
- N-Methyl-acetamide
N-甲基乙酰胺物理化学性质
[ 密度 ]:
0.9±0.1 g/cm3
[ 沸点 ]:
125.0±23.0 °C at 760 mmHg
[ 熔点 ]:
26-28 °C(lit.)
[ 分子式 ]:
C3H7NO
[ 分子量 ]:
73.094
[ 闪点 ]:
46.2±11.9 °C
[ 精确质量 ]:
73.052765
[ PSA ]:
29.10000
[ LogP ]:
-0.09
[ 外观性状 ]:
无色液体或固体
[ 蒸汽压 ]:
5.8±0.5 mmHg at 25°C
[ 折射率 ]:
1.410
[ 储存条件 ]:
库房通风低温干燥
[ 稳定性 ]:
Stable. Combustible. Incompatible with strong oxidizing agents.
[ 水溶解性 ]:
soluble
N-甲基乙酰胺MSDS
N-甲基乙酰胺毒性和生态
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- AC5960000
- CHEMICAL NAME :
- Acetamide, N-methyl-
- CAS REGISTRY NUMBER :
- 79-16-3
- LAST UPDATED :
- 199710
- DATA ITEMS CITED :
- 23
- MOLECULAR FORMULA :
- C3-H7-N-O
- MOLECULAR WEIGHT :
- 73.11
- WISWESSER LINE NOTATION :
- 1VM1
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 5 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 2750 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 3600 mg/kg
- TOXIC EFFECTS :
- Gastrointestinal - other changes Liver - other changes Endocrine - other changes
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Unreported
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 3200 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 4380 mg/kg
- TOXIC EFFECTS :
- Nutritional and Gross Metabolic - weight loss or decreased weight gain Nutritional and Gross Metabolic - body temperature decrease
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 4015 mg/kg
- TOXIC EFFECTS :
- Nutritional and Gross Metabolic - weight loss or decreased weight gain Nutritional and Gross Metabolic - body temperature decrease
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- 16940 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Bird - chicken
- DOSE/DURATION :
- 14 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 90 gm/kg/90D-C
- TOXIC EFFECTS :
- Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis) Blood - changes in bone marrow (not otherwise specified) Nutritional and Gross Metabolic - weight loss or decreased weight gain
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- DOSE :
- 2 gm/kg
- SEX/DURATION :
- female 7 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants)
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Administration onto the skin
- DOSE :
- 1200 mg/kg
- SEX/DURATION :
- female 10-11 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Effects on Embryo or Fetus - fetal death
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intraperitoneal
- DOSE :
- 2 gm/kg
- SEX/DURATION :
- female 15-16 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants)
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- DOSE :
- 3250 mg/kg
- SEX/DURATION :
- female 6-18 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Specific Developmental Abnormalities - craniofacial (including nose and tongue) Reproductive - Specific Developmental Abnormalities - body wall Reproductive - Specific Developmental Abnormalities - musculoskeletal system
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- DOSE :
- 3250 mg/kg
- SEX/DURATION :
- female 6-18 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- DOSE :
- 130 mg/kg
- SEX/DURATION :
- female 6-18 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants)
- TYPE OF TEST :
- DNA inhibition
MUTATION DATA
- TYPE OF TEST :
- Sister chromatid exchange
- TEST SYSTEM :
- Rodent - hamster Ovary
- DOSE/DURATION :
- 10 gm/L
- REFERENCE :
- APHGAO Acta Pharmaceutica Hungarica. (Kultura, POB 149, H-1389 Budapest, Hungary) 1953- Adopts V.24 in 1955. Volume(issue)/page/year: 56,97,1986 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X4317 No. of Facilities: 17 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 851 (estimated) No. of Female Employees: 187 (estimated)
N-甲基乙酰胺安全信息
[ 符号 ]:
GHS08
[ 信号词 ]:
Danger
[ 危害声明 ]:
H360D
[ 警示性声明 ]:
P201-P308 + P313
[ 个人防护装备 ]:
Eyeshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges
[ 危害码 (欧洲) ]:
T:Toxic;
[ 风险声明 (欧洲) ]:
R61
[ 安全声明 (欧洲) ]:
S53-S45
[ 危险品运输编码 ]:
NONH for all modes of transport
[ WGK德国 ]:
2
[ RTECS号 ]:
AC5960000
[ 海关编码 ]:
2942000000
N-甲基乙酰胺合成路线
N-甲基乙酰胺上下游产品
N-甲基乙酰胺上游产品
N-甲基乙酰胺下游产品
N-甲基乙酰胺制备
由乙酸乙酯与甲胺反应而得。将乙酸乙酯和65%的甲胺混合，加热至60℃左右，反应4昼夜，至不再有分层现象，即反应完毕。减压蒸馏回收乙醇，收集95-110℃（4.0kPa）馏分而得N-甲基乙酰胺。
精制方法：N-甲基乙酰胺是由甲胺与乙酸反应合成的。一般利用多次分馏和分步结晶的方法精制，可以得到电导率为5×10-8 S/m的产品。作盐类电导率研究用的N-甲基乙酰胺，可在其中加入五氧化二磷摇振，用玻璃棉过滤后真空蒸馏。重复此操作3次后再蒸馏2次，可得电导率为4.2×10-7 S/m的纯品。
N-甲基乙酰胺海关
[ 海关编码 ]: 2942000000
N-甲基乙酰胺文献
Talanta 147 , 1-7, (2015)
We present a fast, robust and straightforward spin force assisted surface imprinting approach for activated platelets and demonstrate that Heparin induced thrombocytopenia (HIT) platelet aggregation c...
Effects of peptide backbone amide-to-ester bond substitution on the cleavage frequency in electron capture dissociation and collision-activated dissociation.J. Am. Soc. Mass Spectrom. 22(8) , 1441-52, (2011)
Probing the mechanism of electron capture dissociation on variously modified model peptide polycations has resulted in discovering many ways to prevent or reduce N-Cα bond fragmentation. Here we repor...
[The impact of N, N-dimethylacetamide on the health of workers].Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi 29(11) , 834-6, (2011)
To explore the hepatic toxicity and the exposure biomarkers of N, N-Dimethylacetamide.One hundred forty five objects were chosen by stratified random sampling method. The investigation was performed u...
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