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乙酸松油酯

乙酸松油酯用途

α-Terpinyl acetate 是从 Laurus nobilis L. 精油中分离出的一种单萜酯。α-Terpinyl acetate 是竞争性的 P450 2B6 底物,与其活性部位结合的 Kd 值为 5.4  μM 。
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乙酸松油酯名称

[ CAS 号 ]:
80-26-2

[ 中文名 ]:
(±)-α-乙酸松油酯

[ 英文名 ]:
α-​Terpinyl acetate

[中文别名 ]:

[英文别名 ]:

乙酸松油酯生物活性

[ 描述 ]:

α-Terpinyl acetate 是从 Laurus nobilis L. 精油中分离出的一种单萜酯。α-Terpinyl acetate 是竞争性的 P450 2B6 底物,与其活性部位结合的 Kd 值为 5.4  μM 。

[ 相关类别 ]:

信号通路 >> 代谢酶/蛋白酶 >> 细胞色素P450
研究领域 >> 代谢疾病

[ 靶点 ]

CYP2B6:5.4  μM (Kd)


[体外研究]

α-乙酸松油酯抑制P450 2B6的安非他酮羟基化活性,IC50值为10.4μM,α-乙酸松油酯为P450 2B6的竞争性抑制剂,Ki值为7.6μM[2]。

[参考文献]

[1]. Fidan H, et al. Chemical Composition and Antimicrobial Activity of Laurus nobilis L. Essential Oils from Bulgaria. Molecules. 2019 Feb 22;24(4).

[2]. Lee Y, et al. Inhibitory effect of α-terpinyl acetate on cytochrome P450 2B6 enzymatic activity. Chem Biol Interact. 2018 Jun 1;289:90-97.

乙酸松油酯物理化学性质

[ 密度 ]:
1.0±0.1 g/cm3

[ 沸点 ]:
239.9±9.0 °C at 760 mmHg

[ 熔点 ]:
220 °C

[ 分子式 ]:
C12H20O2

[ 分子量 ]:
196.286

[ 闪点 ]:
83.0±17.1 °C

[ 精确质量 ]:
196.146332

[ PSA ]:
26.30000

[ LogP ]:
3.67

[ 外观性状 ]:
透明液体

[ 蒸汽压 ]:
0.0±0.5 mmHg at 25°C

[ 折射率 ]:
1.467

[ 储存条件 ]:
室温,干燥

乙酸松油酯MSDS

乙酸松油酯毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :
OT0200000
CHEMICAL NAME :
p-Menth-1-en-8-ol, acetate
CAS REGISTRY NUMBER :
80-26-2
BEILSTEIN REFERENCE NO. :
3198769
LAST UPDATED :
199709
DATA ITEMS CITED :
6
MOLECULAR FORMULA :
C12-H20-O2
MOLECULAR WEIGHT :
196.32
WISWESSER LINE NOTATION :
L6UTJ A DXOV1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
5075 mg/kg
TOXIC EFFECTS :
Sense Organs and Special Senses (Olfaction) - effect, not otherwise specified Sense Organs and Special Senses (Eye) - effect, not otherwise specified Behavioral - somnolence (general depressed activity)
REFERENCE :
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7. Volume(issue)/page/year: 2,327,1964
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
4800 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 58(10),27,1993
TYPE OF TEST :
LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Mammal - species unspecified
DOSE/DURATION :
>1 gm/m3
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 58(10),27,1993 ** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST :
TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
130 mg/m3/4H/17W-I
TOXIC EFFECTS :
Brain and Coverings - recordings from specific areas of CNS Liver - fatty liver degeneration Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - transaminases
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 58(10),27,1993 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X2063 No. of Facilities: 4671 (estimated) No. of Industries: 24 No. of Occupations: 23 No. of Employees: 44114 (estimated) No. of Female Employees: 28016 (estimated)
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乙酸松油酯安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H315-H319

[ 警示性声明 ]:
P305 + P351 + P338

[ 个人防护装备 ]:
Eyeshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ 危害码 (欧洲) ]:
Xi

[ 风险声明 (欧洲) ]:
R36/38

[ 安全声明 (欧洲) ]:
S26-S36

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
2

[ RTECS号 ]:
OT0200000

[ 海关编码 ]:
2915390090

乙酸松油酯上下游产品

乙酸松油酯制备

1.主要以松节油为原料进行生产。

2.将乙酸、硫酸的混合水溶液加入松节油中,在30~40℃下放置数小时,之后使油层析出,分离后经中和、减压蒸馏即得。也可由松油醇、醋酐和无水乙酸钠反应,经中和、洗涤、分离、蒸馏制得.

3. 烟草:FC,18。

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乙酸松油酯海关

[ 海关编码 ]: 2915390090

[ 中文概述 ]:
2915390090. 其他乙酸酯. 增值税率:17.0%. 退税率:13.0%. 监管条件:AB(入境货物通关单,出境货物通关单). 最惠国关税:5.5%. 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ 监管条件 ]: A.入境货物通关单 B.出境货物通关单

[ 检验检疫 ]: R.进口食品卫生监督检验 S.出口食品卫生监督检验 M.进口商品检验 N.出口商品检验

[ Summary ]:
2915390090. esters of acetic acid. VAT:17.0%. Tax rebate rate:13.0%. Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward). MFN tariff:5.5%. General tariff:30.0%

乙酸松油酯文献

Identification of olfactory receptor neurons in Uraba lugens (Lepidoptera: Nolidae) and its implications for host range.

J. Insect Physiol. 78 , 33-46, (2015)

Phytophagous insects detect volatile compounds produced by host and non-host plants, using species-specific sets of olfactory receptor neurons (ORNs). To investigate the relationship between the range...

Chemical composition and antibacterial activities of seven Eucalyptus species essential oils leaves.

Biol. Res. 48 , 7, (2015)

In this paper, we have studied the essential oils chemical composition of the leaves of seven Eucalyptus species developed in Tunisia. Eucalyptus leaves were picked from trees growing in different arb...

Differential effects of some natural compounds on the transdermal absorption and penetration of caffeine and salicylic acid.

Int. J. Pharm. 483(1-2) , 151-7, (2015)

Many natural products have the potential to modulate the dermal penetration of topically applied drugs and chemicals. We studied the effect of five natural compounds (hydroxycitronellal, limonene 1,2-...


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相关化合物

【乙酸松油酯】化源网提供乙酸松油酯CAS号80-26-2,乙酸松油酯MSDS及其说明、性质、英文名、生产厂家、作用/用途、分子量、密度、沸点、熔点、结构式等。CAS号查询乙酸松油酯上化源网,专业又轻松。>>电脑版:乙酸松油酯

标题:乙酸松油酯_MSDS_用途_密度_乙酸松油酯CAS号【80-26-2】_化源网 地址:https://m.chemsrc.com/mip/cas/80-26-2_509691.html