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头孢泊肟

头孢泊肟用途

头孢泊肟(头孢泊肟酸)是一种对革兰氏阳性菌和革兰氏阴性菌有效的抗生素。头孢泊肟抑制微生物群中的大多数细胞。头孢泊肟可用于急性中耳炎、鼻窦炎和口咽炎的研究[1][2]。

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头孢泊肟名称

[ CAS 号 ]:
80210-62-4

[ 中文名 ]:
头孢泊肟

[ 英文名 ]:
cefpodoxime

[中文别名 ]:

[英文别名 ]:

Cefpodoxime Acid
cefpodoxime
cefpodoxima
U 76253A
Cefpodoxime Proxetil EP Impurity A
Cefpodoxime Proxetil Impurity 1

头孢泊肟生物活性

[ 描述 ]:

[ 相关类别 ]:

研究领域 >> 感染

信号通路 >> 抗感染 >> 细菌

[体外研究]

头孢泊肟(头孢泊肟酸)抑制革兰氏阴性厌氧菌(类杆菌科),MIC值为0.125-4mg/L。头孢泊肟抑制小静脉内拉的MIC值为0.25-8 mg/L。头孢泊肟抑制微消化链球菌、细毛消化链球菌和溴瘤胃球菌,MIC值<2 mg/L[1]。头孢泊肟(头孢泊肟酸)抑制肺炎链球菌和化脓链球菌的细菌群。cfu[2]。

[体内研究]

头孢菌素(2.5-50 mg/kg；p.o；每8小时；持续48小时)对小鼠具有良好的疗效[3]。动物模型：雌性瑞士CD1小鼠[3]剂量：2.5、5、10、25、40和50mg/kg给药：口服给药；每8小时；48小时结果：获得的疗效值>350。

[参考文献]

[1]. Werner H, et, al. Comparative in vitro activity of cefpodoxime against anaerobes other than Bacteroides fragilis. Infection. 1991 Sep-Oct;19(5):377-9.

[2]. Valentini S, et, al. In-vitro evaluation of cefpodoxime. J Antimicrob Chemother. 1994 Mar;33(3):495-508.

[3]. Pérez-Trallero E, et, al. Prediction of in-vivo efficacy by in-vitro early bactericidal activity with oral beta-lactams, in a dose-ranging immunocompetent mouse sepsis model, using strains of Streptococcus pneumoniae with decreasing susceptibilities to penicillin. J Chemother. 2001 Apr;13(2):118-25.

头孢泊肟物理化学性质

[ 密度 ]:
1.8±0.1 g/cm3

[ 熔点 ]:
200-202ºC

[ 分子式 ]:
C₁₅H₁₇N₅O₆S₂

[ 分子量 ]:
427.455

[ 精确质量 ]:
427.062012

[ PSA ]:
209.98000

[ LogP ]:
0.94

[ 外观性状 ]:
白色至淡黄色粉末

[ 折射率 ]:
1.780

[ 储存条件 ]:
-20°C，密闭，干燥

头孢泊肟MSDS

头孢泊肟安全信息

[ 符号 ]:

GHS08

[ 信号词 ]:
Danger

[ 危害声明 ]:
H317-H334

[ 警示性声明 ]:
P261-P280-P342 + P311

[ 危害码 (欧洲) ]:
Xn

[ 风险声明 (欧洲) ]:
42/43

[ 安全声明 (欧洲) ]:
22-36/37-45

[ 危险品运输编码 ]:
NONH for all modes of transport

头孢泊肟合成路线

头孢泊肟上下游产品

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头孢泊肟下游产品

头孢泊肟文献

Isolation of Escherichia coli strains with AcrAB-TolC efflux pump-associated intermediate interpretation or resistance to fluoroquinolone, chloramphenicol and aminopenicillin from dogs admitted to a university veterinary hospital.

J. Vet. Med. Sci. 76(7) , 937-45, (2014)

Understanding the prevalence of antimicrobial-resistance and the relationship between emergence of resistant bacteria and clinical treatment can facilitate design of effective treatment strategies. We...

Increase in resistance to extended-spectrum cephalosporins in Salmonella isolated from retail chicken products in Japan.

PLoS ONE 10(2) , e0116927, (2015)

Extended-spectrum β-lactamase (ESBL)-producing Salmonella are one of the most important public health problems in developed countries. ESBL-producing Salmonella strains have been isolated from humans ...

Cephalosporinases associated with outer membrane vesicles released by Bacteroides spp. protect gut pathogens and commensals against β-lactam antibiotics.

J. Antimicrob. Chemother. 70(3) , 701-9, (2015)

To identify β-lactamase genes in gut commensal Bacteroides species and to assess the impact of these enzymes, when carried by outer membrane vesicles (OMVs), in protecting enteric pathogens and commen...

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