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强啡肽A

强啡肽A用途

Dynorphin A 是一种内源性阿片肽,是一种高效的 kappa 阿片受体 (KOR) 激活剂。Dynorphin A 也作为其他阿片受体的激动剂,如 mu (MOR) 和 delta (DOR)。

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强啡肽A名称

[ CAS 号 ]:
80448-90-4

[ 中文名 ]:
强啡肽A

[ 英文名 ]:
Dynorphin A trifluoroacetate salt

[英文别名 ]:

Dynorphin acetate
DYNORPHIN A PORCINE
YGGFLRRIRPKLKWDNQ
DYNORPHIN A AMIDE

强啡肽A生物活性

[ 描述 ]:

Dynorphin A 是一种内源性阿片肽,是一种高效的 kappa 阿片受体 (KOR) 激活剂。Dynorphin A 也作为其他阿片受体的激动剂,如 mu (MOR) 和 delta (DOR)。

[ 相关类别 ]:

信号通路 >> G 蛋白偶联受体/G 蛋白 >> 阿片受体

信号通路 >> 神经信号通路 >> 阿片受体

研究领域 >> 神经疾病

[参考文献]

[1]. Zhang, et al.Dynorphin A as a Potential Endogenous Ligand for Four Members of the Opioid Receptor Gene Family. J Pharmacol Exp Ther. 1998 Jul;286(1):136-41.

强啡肽A物理化学性质

[ 密度 ]:
1.5±0.1 g/cm3

[ 分子式 ]:
C₉₉H₁₅₅N₃₁O₂₃

[ 分子量 ]:
2147.484

[ 精确质量 ]:
2146.191162

[ PSA ]:
917.37000

[ LogP ]:
-1.52

[ 折射率 ]:
1.669

[ 储存条件 ]:
−20°C

强啡肽AMSDS

详细MSDS(安全技术说明书)

强啡肽A安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 安全声明 (欧洲) ]:
22-24/25

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

强啡肽A文献

Dynorphin A as a potential endogenous ligand for four members of the opioid receptor gene family.

J. Pharmacol. Exp. Ther. 286 , 136-141, (1998)

Dynorphin A is an endogenous opioid peptide that activates the kappa opioid receptor (KOR) with high potency. Some studies also showed that the distribution and functional activity of dynorphin A are ...

Structure-activity relationship studies of dynorphin A and related peptides.

Peptides 19 , 1277-1292, (1998)

An up-to-date review is presented covering all the available information concerning the isolation, discovery, synthesis, conformation, receptor binding characteristics, pharmacological properties and ...

The kappa opioid receptor and dynorphin co-localize in vasopressin magnocellular neurosecretory neurons in guinea-pig hypothalamus.

Neuroscience 96 , 373-383, (2000)

The relationship between the cloned kappa opioid receptor, dynorphin, and the neurohypophysial hormones vasopressin and oxytocin was analysed in the guinea-pig hypothalamic magnocellular neurosecretor...

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