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1-二苯甲基-4-甲基哌嗪

1-二苯甲基-4-甲基哌嗪名称

[ CAS 号 ]:
82-92-8

[ 中文名 ]:
苯甲嗪

[ 英文名 ]:
Cyclizine

[中文别名 ]:

1-二苯甲基-4-甲基哌嗪

[英文别名 ]:

Ciclizina
Marzine
N-benzhydryl-N'-methylpiperazine
Valoid
Bw 47-83
Marazine
1-Benzhydryl-4-methyl-piperazin
Emoquil
Nautazine
Marezine

1-二苯甲基-4-甲基哌嗪物理化学性质

[ 分子式 ]:
C₁₈H₂₂N₂

[ 分子量 ]:
266.38100

[ 精确质量 ]:
266.17800

[ PSA ]:
6.48000

[ LogP ]:
2.89920

[ 储存条件 ]:
室温，干燥，密封

1-二苯甲基-4-甲基哌嗪MSDS

1-二苯甲基-4-甲基哌嗪毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: TL6475000

CHEMICAL NAME :: Piperazine, 1-(diphenylmethyl)-4-methyl-

CAS REGISTRY NUMBER :: 82-92-8

BEILSTEIN REFERENCE NO. :: 0230441

LAST UPDATED :: 199612

DATA ITEMS CITED :: 5

MOLECULAR FORMULA :: C18-H22-N2

MOLECULAR WEIGHT :: 266.42

WISWESSER LINE NOTATION :: T6N DNTJ AYR&R& D1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Human - woman

DOSE/DURATION :: 126 mg/kg/6W-I

TOXIC EFFECTS :: Blood - agranulocytosis

REFERENCE :: BMJOAE British Medical Journal. (British Medical Assoc., BMA House, Tavistock Sq., London WC1H 9JR, UK) V.1- 1857- Volume(issue)/page/year: 292,174,1986

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 147 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,218,1972 ** REPRODUCTIVE DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 450 mg/kg

SEX/DURATION :: female 10-15 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Specific Developmental Abnormalities - craniofacial (including nose and tongue) Reproductive - Specific Developmental Abnormalities - musculoskeletal system

REFERENCE :: BCFAAI Bollettino Chimico Farmaceutico. (Societa Editoriale Farmaceutica, Via Ausonio 12, 20123 Milan, Italy) V.33- 1894- Volume(issue)/page/year: 109,323,1970

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 450 mg/kg

SEX/DURATION :: female 10-15 day(s) after conception

TOXIC EFFECTS :: Reproductive - Specific Developmental Abnormalities - homeostasis Reproductive - Effects on Newborn - stillbirth

REFERENCE :: BCFAAI Bollettino Chimico Farmaceutico. (Societa Editoriale Farmaceutica, Via Ausonio 12, 20123 Milan, Italy) V.33- 1894- Volume(issue)/page/year: 109,323,1970 *** REVIEWS *** TOXICOLOGY REVIEW ADVPA3 Advances in Pharmacology. (New York, NY) V.1-6, 1962-68. For publisher information, see AVPCAQ. Volume(issue)/page/year: 4,263,1966

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1-二苯甲基-4-甲基哌嗪安全信息

[ 危害码 (欧洲) ]:
T+

[ 海关编码 ]:
2933599090

1-二苯甲基-4-甲基哌嗪合成路线

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1-二苯甲基-4-甲基哌嗪海关

[ 海关编码 ]: 2933599090

[ 中文概述 ]:
2933599090. 其他结构上有嘧啶环的化合物(包括其他结构上有哌嗪环的化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期

[ Summary ]:
2933599090. other compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%