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二(2-氯乙基)胺盐酸盐

二(2-氯乙基)胺盐酸盐用途

盐酸双(2-氯乙基)胺是一种生物化学试剂,可作为生物材料或有机化合物用于生命科学相关研究。

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二(2-氯乙基)胺盐酸盐名称

[ CAS 号 ]:
821-48-7

[ 中文名 ]:
二(2-氯乙基)胺盐酸盐

[ 英文名 ]:
Bis(2-Chloroethyl)amine hydrochloride

[中文别名 ]:

[英文别名 ]:

2-Chlor-N-(2-chlorethyl)ethanaminhydrochlorid
MFCD00012515
Bis(2-chloroethyl)amine Hydrochloride
EINECS 212-479-5
2-chloro-N-(2-chloroethyl)ethanamine hydrochloride
Bis(β-chloroethyl)amine hydrochloride
Bis(2-Chloroethyl)Amine HCL

二(2-氯乙基)胺盐酸盐生物活性

[ 描述 ]:

盐酸双(2-氯乙基)胺是一种生物化学试剂,可作为生物材料或有机化合物用于生命科学相关研究。

[ 相关类别 ]:

研究领域 >> 其他

信号通路 >> 其他 >> 其他

[体外研究]

双(2-氯乙基)胺盐酸盐用作医药中间体。

二(2-氯乙基)胺盐酸盐物理化学性质

[ 密度 ]:
1.125 g/cm3

[ 沸点 ]:
204.2ºC at 760 mmHg

[ 熔点 ]:
212-214 °C(lit.)

[ 分子式 ]:
C₄H₁₀Cl₃N

[ 分子量 ]:
178.49

[ 闪点 ]:
77.3ºC

[ 精确质量 ]:
176.987885

[ PSA ]:
12.03000

[ LogP ]:
2.24650

[ 外观性状 ]:
白色至淡米色粉末

[ 储存条件 ]:
库房通风低温干燥,与食品原料分开存放

[ 水溶解性 ]:
SOLUBLE

二(2-氯乙基)胺盐酸盐MSDS

二(2-氯乙基)胺盐酸盐毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: IA1225000

CHEMICAL NAME :: Diethylamine, 2,2'-dichloro-, hydrochloride

CAS REGISTRY NUMBER :: 821-48-7

LAST UPDATED :: 199701

DATA ITEMS CITED :: 17

MOLECULAR FORMULA :: C4-H9-Cl2-N.Cl-H

MOLECULAR WEIGHT :: 178.50

WISWESSER LINE NOTATION :: G2M2G &GH

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 100 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intramuscular

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 160 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LCLo - Lowest published lethal concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1000 mg/m3/10M

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 20 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intramuscular

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 280 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

DOSE :: 2500 ug/kg

SEX/DURATION :: female 11 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

DOSE :: 40 mg/kg

SEX/DURATION :: female 11 day(s) after conception

TOXIC EFFECTS :: Reproductive - Specific Developmental Abnormalities - Central Nervous System Reproductive - Specific Developmental Abnormalities - musculoskeletal system

MUTATION DATA

TYPE OF TEST :: DNA adduct

TEST SYSTEM :: Rodent - mouse Ascites tumor

DOSE/DURATION :: 170 umol/kg

REFERENCE :: CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year: 33,1048,1973

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二(2-氯乙基)胺盐酸盐安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H315-H319-H335

[ 警示性声明 ]:
P261-P305 + P351 + P338

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xi:Irritant;

[ 风险声明 (欧洲) ]:
R36/37/38

[ 安全声明 (欧洲) ]:
S26

[ 危险品运输编码 ]:
2811

[ WGK德国 ]:
3

[ RTECS号 ]:
IA1225000

[ 包装等级 ]:
III

[ 危险类别 ]:
8

[ 海关编码 ]:
29211980

二(2-氯乙基)胺盐酸盐合成路线

二(2-氯乙基)胺盐酸盐上下游产品

二(2-氯乙基)胺盐酸盐上游产品

二(2-氯乙基)胺盐酸盐下游产品

二(2-氯乙基)胺盐酸盐制备

由二乙醇胺和氯化亚砜反应得到。将氯化亚砜溶于氯仿中，于0℃以下滴加二乙醇胺和氯仿的混合液。控制滴加速度，使温度维持在-4-6℃，加完后，保温搅拌30min。再在室温搅拌1h，加热至60-65℃，待结晶全部析出后，加无水乙醇，加热回流使全部溶解。趁热倒出，自然冷却，析出结晶。次日过滤，用氯仿或无水乙醇洗涤2次。干燥，得成品，收率76%

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二(2-氯乙基)胺盐酸盐海关

[ 海关编码 ]: 2921199090

[ 中文概述 ]:
2921199090 其他无环单胺及其衍生物及其盐。监管条件:无。增值税率:17.0%。退税率:9.0%。最惠国关税:6.5%。普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2921199090 other acyclic monoamines and their derivatives; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%

二(2-氯乙基)胺盐酸盐文献

Occupational exposure to nor-nitrogen mustard: chemical and biological monitoring.

Toxicol. Ind. Health 11(1) , 89-97, (1995)

Nor-nitrogen mustard is an alkylating agent used in kilogram quantities in the production of various cytostatics. It has been shown to be mutagenic in vitro, and therefore must be regarded as a health...

Basic principles in preclinical cancer chemotherapy.

J. Cancer Res. Clin. Oncol. 116(5) , 411-24, (1990)

Covalent binding of nitrogen mustards to the cysteine-34 residue in human serum albumin.

Arch. Toxicol. 76(2) , 83-8, (2002)

Covalent binding of various clinically important nitrogen mustards to the cysteine-34 residue of human serum albumin, in vitro and in vivo, is demonstrated. A rapid method for detection of these adduc...

更多文献

二(2-氯乙基)胺盐酸盐

二(2-氯乙基)胺盐酸盐用途

二(2-氯乙基)胺盐酸盐名称

二(2-氯乙基)胺盐酸盐生物活性

二(2-氯乙基)胺盐酸盐物理化学性质

二(2-氯乙基)胺盐酸盐MSDS

详细MSDS(安全技术说明书)

二(2-氯乙基)胺盐酸盐毒性和生态

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

二(2-氯乙基)胺盐酸盐安全信息

二(2-氯乙基)胺盐酸盐合成路线

详细合成路线

二(2-氯乙基)胺盐酸盐上下游产品

二(2-氯乙基)胺盐酸盐上游产品

二(2-氯乙基)胺盐酸盐下游产品

二(2-氯乙基)胺盐酸盐制备

二(2-氯乙基)胺盐酸盐海关

二(2-氯乙基)胺盐酸盐文献

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