三(2-氯乙基)胺盐酸盐

三(2-氯乙基)胺盐酸盐用途

Trichlormethine hydrochloride是治疗癌症和关节炎的细胞生长抑制剂; 对人类有致癌作用。

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三(2-氯乙基)胺盐酸盐名称

[ CAS 号 ]:
817-09-4

[ 中文名 ]:
三(2-氯乙基)胺盐酸盐

[ 英文名 ]:
Trichlormethine (hydrochloride)

[中文别名 ]:

三(2-氯乙基)胺盐酸盐

[英文别名 ]:

Trichlormethin
Sinalost
Lekamin
Hn3 hcl
Trimustine
tris(2-chloroethyl)ammonium hydrochloride
EINECS 212-442-3
MFCD00012520
2,2',2''-Trichlortriethylamin-hydrochlorid
HN3 hydrochloride

三(2-氯乙基)胺盐酸盐生物活性

[ 描述 ]:

Trichlormethine hydrochloride是治疗癌症和关节炎的细胞生长抑制剂; 对人类有致癌作用。

[ 相关类别 ]:

信号通路 >> 其他 >> 其他

研究领域 >> 癌症

[体外研究]

可以在0.01单层的表面覆盖率下检测到三氯甲基,对应于表面积为2.2m 2/g的土壤,其对应于20ppm(质量/质量)。 TEA是三氯甲基的彻底水解产物,在0.001单层的表面覆盖率下检测到,相当于0.86 ppm [1]。

[体内研究]

三氯甲基盐酸盐对精子发生的后期生成阶段具有遗传风险,并且通过其对精母细胞的作用而干扰精子头部的形态。发现三氯甲基盐酸盐的毒性作用影响小鼠的体重,降低睾丸的相对重量,破坏生精小管中的精子发生,引起附睾中多核细胞的出现,并增加完全成熟的精子头部异常率[2]。

[动物实验]

小鼠：使用显性致死突变试验（DLM）和精子异常试验，在给药1周后评估细胞抑制性三氯甲基盐酸盐的遗传效应。剂量为0.5mg / kg，连续7天，相当于人治疗剂量。同时，评估细胞生长抑制剂对男性性器官的直接毒性作用[2]。

[参考文献]

[1]. Gresham GL, et al. Identification of the nitrogen-based blister agents bis(2-chloroethyl)methylamine (HN-2) and tris(2-chloroethyl)amine (HN-3) and their hydrolysis products on soil using ion trap secondary ion mass spectrometry. J Mass Spectrom. 2000 Dec;35(12):1460-9.

[2]. Sýkora I, et al. Trichlormethine hydrochloride and correlation of its mutagenic and toxic effects on male germ cells in mice. Mutat Res. 1992 Apr;266(2):291-7.

[相关活性小分子]

三(2-氯乙基)胺盐酸盐物理化学性质

[ 沸点 ]:
156.2ºC at 760 mmHg

[ 熔点 ]:
127-130ºC(lit.)

[ 分子式 ]:
C₆H₁₃Cl₄N

[ 分子量 ]:
240.98600

[ 闪点 ]:
48.3ºC

[ 精确质量 ]:
238.98000

[ PSA ]:
3.24000

[ LogP ]:
2.80680

[ 储存条件 ]:
Poison room

三(2-氯乙基)胺盐酸盐MSDS

三(2-氯乙基)胺盐酸盐毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: YE2800000

CHEMICAL NAME :: Triethylamine, 2,2',2''-trichloro-, hydrochloride

CAS REGISTRY NUMBER :: 817-09-4

LAST UPDATED :: 199512

DATA ITEMS CITED :: 27

MOLECULAR FORMULA :: C6-H12-Cl3-N.Cl-H

MOLECULAR WEIGHT :: 241.00

WISWESSER LINE NOTATION :: G2N2G2G &GH

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Human

DOSE/DURATION :: 214 ug/kg

TOXIC EFFECTS :: Blood - leukopenia

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Human

DOSE/DURATION :: 30 ug/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - anorexia (human) Gastrointestinal - nausea or vomiting

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Human

DOSE/DURATION :: 100 ug/kg

TOXIC EFFECTS :: Behavioral - headache Vascular - thrombosis distant from injection site Gastrointestinal - nausea or vomiting

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 5 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 750 ug/kg

TOXIC EFFECTS :: Tumorigenic - active as anti-cancer agent

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 2 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 700 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1100 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1600 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 2 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD75 - Lethal Dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 1 mg/kg

TOXIC EFFECTS :: Gastrointestinal - ulceration or bleeding from small intestine Gastrointestinal - hypermotility, diarrhea Gastrointestinal - nausea or vomiting

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 2 mg/kg

TOXIC EFFECTS :: Gastrointestinal - changes in structure or function of salivary glands

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 2500 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 10 mg/kg/9W-I

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Lungs, Thorax, or Respiration - tumors Tumorigenic - tumors at site of application

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intravenous

DOSE :: 2400 ug/kg

SEX/DURATION :: male 1 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Paternal Effects - spermatogenesis (incl. genetic material, sperm morphology, motility, and count) Reproductive - Paternal Effects - testes, epididymis, sperm duct

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

DOSE :: 1500 ug/kg

SEX/DURATION :: male 1 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Paternal Effects - testes, epididymis, sperm duct

TYPE OF TEST :: DNA damage

TYPE OF TEST :: Dominant lethal test

MUTATION DATA

TEST SYSTEM :: Rodent - mouse

DOSE/DURATION :: 3500 ug/kg/7D (Continuous)

REFERENCE :: MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 266,291,1992 *** REVIEWS *** IARC Cancer Review:Animal Sufficient Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 50,143,1990 IARC Cancer Review:Animal Inadequate Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 9,229,1975 IARC Cancer Review:Human No Adequate Data IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 9,229,1975 IARC Cancer Review:Human No Adequate Data IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 50,143,1990 IARC Cancer Review:Group 2B IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 50,143,1990

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三(2-氯乙基)胺盐酸盐安全信息

[ 符号 ]:

GHS05, GHS06, GHS08

[ 信号词 ]:
Danger

[ 危害声明 ]:
H300-H314-H351

[ 警示性声明 ]:
P264-P280-P305 + P351 + P338-P310

[ 个人防护装备 ]:
Eyeshields;Faceshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges

[ 危害码 (欧洲) ]:
T+: Very toxic;Xi: Irritant;

[ 风险声明 (欧洲) ]:
R26/27/28;R33;R40

[ 安全声明 (欧洲) ]:
S23-S24/25

[ 危险品运输编码 ]:
UN 2928 6.1/PG 1

[ WGK德国 ]:
3

[ RTECS号 ]:
YE2800000

[ 包装等级 ]:
II

[ 危险类别 ]:
6.1(a)

[ 海关编码 ]:
2921199090

三(2-氯乙基)胺盐酸盐合成路线

三(2-氯乙基)胺盐酸盐上下游产品

三(2-氯乙基)胺盐酸盐上游产品

三(2-氯乙基)胺盐酸盐下游产品

三(2-氯乙基)胺盐酸盐海关

[ 海关编码 ]: 2921199090

[ 中文概述 ]:
2921199090 其他无环单胺及其衍生物及其盐。监管条件:无。增值税率:17.0%。退税率:9.0%。最惠国关税:6.5%。普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2921199090 other acyclic monoamines and their derivatives; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%

三(2-氯乙基)胺盐酸盐文献

Identification of the nitrogen-based blister agents bis(2-chloroethyl)methylamine (HN-2) and tris(2-chloroethyl)amine (HN-3) and their hydrolysis products on soil using ion trap secondary ion mass spectrometry.

J. Mass Spectrom. 35(12) , 1460-9, (2000)

The nitrogen blister agents HN-2 (bis(2-chloroethyl)methylamine) and HN-3 (tris(2-chloroethyl)amine) were directly analyzed on the surface of soil samples using ion trap secondary ion mass spectrometr...

Ameliorative effect of DRDE 07 and its analogues on the systemic toxicity of sulphur mustard and nitrogen mustard in rabbit.

Hum. Exp. Toxicol. 29(9) , 747-55, (2010)

Despite extensive research efforts, there is no unanimous approval of any animal model to evaluate the toxicity of sulphur mustard [SM; bis (2-chloroethyl) sulphide] or nitrogen mustard [HN-3; tris-(2...

Carcinogenicity of trichloromethine hydrochloride (TS-160 Spofa) and morphological damage after its intraamniotic injection.

Neoplasma 28(5) , 565-74, (1981)

The cytostatic TS-160 (trichloromethine hydrochloride, tris-/2-chloroethyl/amine hydrochloride) was injected subcutaneously into SPF Wistar rats of both sexes. After all doses used, spindle-cell or ev...

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