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阿尔吡登

阿尔吡登用途

Alpidem选择性结合含有GABAA受体的α1β2γ2亚单位,IC50为17 nM,并发挥抗焦虑作用[1]。

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阿尔吡登名称

[ CAS 号 ]:
82626-01-5

[ 中文名 ]:
阿吡坦

[ 英文名 ]:
alpidem

[中文别名 ]:

阿尔吡登

[英文别名 ]:

ALPIDEM
Ananxyl
SL 80.0342-00
Alpidemum [Latin]

阿尔吡登生物活性

[ 描述 ]:

Alpidem选择性结合含有GABAA受体的α1β2γ2亚单位,IC50为17 nM,并发挥抗焦虑作用[1]。

[ 相关类别 ]:

信号通路 >> 跨膜转运 >> GABA受体

研究领域 >> 神经疾病

信号通路 >> 神经信号通路 >> GABA受体

[参考文献]

[1]. Faure-Halley C, et al. Expression and properties of recombinant alpha 1 beta 2 gamma 2 and alpha 5 beta 2 gamma 2 forms of the rat GABAA receptor. Eur J Pharmacol. 1993 Aug 15;246(3):283-7.

阿尔吡登物理化学性质

[ 密度 ]:
1.24g/cm3

[ 熔点 ]:
136-138ºC

[ 分子式 ]:
C₂₁H₂₃Cl₂N₃O

[ 分子量 ]:
404.34

[ 精确质量 ]:
403.12200

[ PSA ]:
37.61000

[ LogP ]:
5.49920

[ 外观性状 ]:
白色至灰白色固体

[ 折射率 ]:
1.606

[ 储存条件 ]:
Refrigerator

[ 水溶解性 ]:
DMSO: ≥10mg/mL

阿尔吡登MSDS

详细MSDS(安全技术说明书)

阿尔吡登安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H302

[ 危险品运输编码 ]:
NONH for all modes of transport

阿尔吡登制备

化合物(I)和草酰氯及二正丙胺作用，可得阿吡坦。

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阿尔吡登文献

On the therapeutic action of alpidem in anxiety disorders: an overview of the European data.

Pharmacopsychiatry 23 Suppl 3 , 129-34, (1990)

This review analyzes the available data on the therapeutic activity of alpidem in various anxiety syndromes. Up to now, 17 studies have been completed in Europe, dealing with a total population of mor...

Morphology of hepatic stellate cells in patients with fulminant or subfulminant hepatitis requiring liver transplantation.

J. Submicrosc. Cytol. Pathol. 28(1) , 5-12, (1996)

Hepatic stellate cells were studied by immuno-cytochemistry with anti smooth muscle alpha-actin antibody (an activation marker for these cells) and electron microscopy, in eleven patients transplanted...

Studies with alpidem in normal volunteers and anxious patients.

Pharmacopsychiatry 23 Suppl 3 , 120-3, (1990)

Alpidem, an imidazo-pyridine compound, has been evaluated as an anxiolytic in comparison with placebo and lorazepam. In the first of our normal volunteer studies, we compared single doses of alpidem, ...

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