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1-金刚烷甲酸

1-金刚烷甲酸用途

【用途一】
用作合成盐酸金刚乙胺的中间体

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1-金刚烷甲酸名称

[ CAS 号 ]:
828-51-3

[ 中文名 ]:
1-金刚烷甲酸

[ 英文名 ]:
Adamantane-1-carboxylic acid

[中文别名 ]:

[英文别名 ]:

1-adamantylcarboxylic acid
Adamantanecarboxylic acid
1-adamantylmethanoic acid
adamantane carboxylic acid
Adamantoic acid
1-ADAMANTOIC ACID
MFCD00074720
1-Adamantanecarboxylic acid
Tricyclo[3.3.1.1]decane-1-carboxylic acid
adamant-1-ylcarboxylic acid

1-金刚烷甲酸物理化学性质

[ 密度 ]:
1.2±0.1 g/cm3

[ 沸点 ]:
304.7±10.0 °C at 760 mmHg

[ 熔点 ]:
172-174 °C(lit.)

[ 分子式 ]:
C₁₁H₁₆O₂

[ 分子量 ]:
180.243

[ 闪点 ]:
142.0±13.7 °C

[ 精确质量 ]:
180.115036

[ PSA ]:
37.30000

[ LogP ]:
2.60

[ 外观性状 ]:
白色结晶粉末

[ 蒸汽压 ]:
0.0±1.4 mmHg at 25°C

[ 折射率 ]:
1.573

[ 储存条件 ]:
室温

[ 水溶解性 ]:
水溶性：不溶；可溶于：苯,甲醇,丙酮,乙醇

1-金刚烷甲酸MSDS

1-金刚烷甲酸毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: AU4452200

CHEMICAL NAME :: 3-Adamantanecarboxylic acid

CAS REGISTRY NUMBER :: 828-51-3

LAST UPDATED :: 199209

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C11-H16-O2

MOLECULAR WEIGHT :: 180.27

WISWESSER LINE NOTATION :: L 66 B6/B-H/DI A B- C 1B ITJ AVQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD - Lethal dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >600 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: PCJOAU Pharmaceutical Chemistry Journal (English Translation). Translation of KHFZAN. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) No.1- 1967- Volume(issue)/page/year: 8,396,1974

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 600 mg/kg

TOXIC EFFECTS :: Behavioral - anticonvulsant

REFERENCE :: RPTOAN Russian Pharmacology and Toxicology (English Translation). Translation of FATOAO. (Euromed Pub., 33, Woodlands Rd., Surbiton, Surrey, UK) V.30- 1967- Volume(issue)/page/year: 43,73,1980

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1-金刚烷甲酸安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危害码 (欧洲) ]:
Xi: Irritant;

[ 风险声明 (欧洲) ]:
R36/37/38

[ 安全声明 (欧洲) ]:
S22-S24/25

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ RTECS号 ]:
AU4452200

[ 海关编码 ]:
2916209090

1-金刚烷甲酸合成路线

1-金刚烷甲酸上下游产品

1-金刚烷甲酸上游产品

1-金刚烷甲酸下游产品

1-金刚烷甲酸制备

1.制法：

于装有搅拌器、温度计、滴液漏斗、通气导管的反应瓶中，加入96%的浓硫酸470g（225mL，4.8mol），100mL四氯化碳，金刚烷（2）13.6g（0.1mol）。冰浴冷至17～19℃，加入1mL98%～100%的甲酸。而后慢慢滴加叔丁醇29.6mL（0.4mol）与98%～100%的甲酸55g（1.2mol）的溶液，控制滴加速度，保持17～25℃约2h加完。加完后继续搅拌反应30min。倒入700g碎冰中，分出有机层，水层用四氯化碳提取3次。合并有机层，加入15mol/L的氨水110mL，充分摇动。过滤生成的铵盐，20mL冷丙酮洗涤。加入250mL水中，用浓盐酸酸化，氯仿提取。氯仿层用无水硫酸钠干燥，蒸出溶剂至干。得粗品（1）12～13g，收率67%～72%，mp173～174℃。用甲醇-水重结晶，mp175～176.5℃。

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1-金刚烷甲酸海关

[ 海关编码 ]: 2916209090

[ 中文概述 ]:
2916209090 其他（环烷、环烯、环萜烯）一元羧酸（包括酸酐、酰卤化物，过氧化物和过氧酸及该税号的衍生物）. 增值税率:17.0% 退税率:9.0% 监管条件:AB(入境货物通关单,出境货物通关单) 最惠国关税:6.5% 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 丙烯酸、丙烯酸盐或酯应报明包装

[ 监管条件 ]: A.入境货物通关单 B.出境货物通关单

[ 检验检疫 ]: R.进口食品卫生监督检验 S.出口食品卫生监督检验 M.进口商品检验 N.出口商品检验

[ Summary ]:
2916209090 other cyclanic, cyclenic or cyclotherpenic monocarboxylic acids, their anhydrides, halides, peroxides, peroxyacids and their derivatives VAT:17.0% Tax rebate rate:9.0% Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward) MFN tariff:6.5% General tariff:30.0%

1-金刚烷甲酸文献

Novel Bradykinin Analogues Modified in the N-Terminal Part of the Molecule with a Variety of Acyl Substituents.

Int. J. Pept. Res. Ther. 18(2) , 117-124, (2012)

In the current work we present some pharmacological characteristics of ten new analogues of bradykinin (Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg) modified in the N-terminal part of the molecule with a vari...

Trace analysis of total naphthenic acids in aqueous environmental matrices by liquid chromatography/mass spectrometry-quadrupole time of flight mass spectrometry direct injection.

J. Chromatogr. A. 1405 , 49-71, (2015)

A rapid and sensitive liquid chromatography quadrupole time of flight method has been established for the determination of total naphthenic acid concentrations in aqueous samples. This is the first me...

Unexpected fluorescent behavior of a 4-amino-1,8-naphthalimide derived beta-cyclodextrin: conformation analysis and sensing properties.

Chem. Commun. (Camb.) (27) , 4091-3, (2009)

A new fluorescent cyclodextrin shows unexpected and strong fluorescence enhancement upon binding of organic molecules, and the enhancing mechanism is found to be different from those reported in the l...

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1-金刚烷甲酸

1-金刚烷甲酸用途

1-金刚烷甲酸名称

1-金刚烷甲酸物理化学性质

1-金刚烷甲酸MSDS

详细MSDS(安全技术说明书)

1-金刚烷甲酸毒性和生态

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

1-金刚烷甲酸安全信息

1-金刚烷甲酸合成路线

详细合成路线

1-金刚烷甲酸上下游产品

1-金刚烷甲酸上游产品

1-金刚烷甲酸下游产品

1-金刚烷甲酸制备

1-金刚烷甲酸海关

1-金刚烷甲酸文献

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