对苯氧基苯酚

对苯氧基苯酚用途

BIF-44, also known as 4-Phenoxyphenol and Hydroquinone monophenyl ether, is a sensitizer of BCL-2-associated X protein (BAX) activation by binding to a pocket formed by the junction of the α3-α4 and α5-α6 hairpins. BIF-44 enhances BAX activity.

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对苯氧基苯酚名称

[ CAS 号 ]:
831-82-3

[ 中文名 ]:
4-苯氧基苯酚

[ 英文名 ]:
4-Phenoxyphenol

[中文别名 ]:

[英文别名 ]:

4-Phenoxyphenol
o-Phenylhydroquinone
EINECS 212-611-1
MFCD00002331
Phenol, 4-phenoxy-

对苯氧基苯酚物理化学性质

[ 密度 ]:
1.2±0.1 g/cm3

[ 沸点 ]:
313.8±25.0 °C at 760 mmHg

[ 熔点 ]:
80-84 °C(lit.)

[ 分子式 ]:
C₁₂H₁₀O₂

[ 分子量 ]:
186.207

[ 闪点 ]:
141.4±17.4 °C

[ 精确质量 ]:
186.068085

[ PSA ]:
29.46000

[ LogP ]:
3.35

[ 外观性状 ]:
白色或淡黄色结晶粉末

[ 蒸汽压 ]:
0.0±0.7 mmHg at 25°C

[ 折射率 ]:
1.605

[ 储存条件 ]:
室温

[ 稳定性 ]:
Stable. Combustible. Incompatible with strong oxidizing agents.

[ 水溶解性 ]:
insoluble

对苯氧基苯酚MSDS

详细MSDS(安全技术说明书)

对苯氧基苯酚安全信息

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xi:Irritant

[ 风险声明 (欧洲) ]:
R36/37/38

[ 安全声明 (欧洲) ]:
S26-S36-S37/39

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ 包装等级 ]:
I; II; III

[ 海关编码 ]:
29095090

对苯氧基苯酚合成路线

详细合成路线

对苯氧基苯酚上下游产品

对苯氧基苯酚上游产品

对苯氧基苯酚下游产品

对苯氧基苯酚制备

4-羟基二苯醚的制备方法很多，其中两条工艺路线原料成本低，工艺简单。
对苯二酚与溴苯反应

以对苯二酚为原料，加入二甲基亚砜溶剂及96％氢氧化钾溶液，同时通入氮气，搅拌下加热至 140 ℃ 时，缓慢滴加溴苯溶液，在(145±5)℃温度下反应8h；反应完毕，水相经盐酸酸化，析出结晶，收率为88％～89％。
对氯苯酚法

向装有温度计、分水器和磁力搅拌器的500mL三口瓶中加入 235g (2.50mol)苯酚、 42.1g (0.75mol)氢氧化钠和150mL甲苯，加热分出水。脱溶剂后，加入 1.75g 铜盐作催化剂，滴加 64.3g (0.50 mol)对氯苯酚，在 175 ℃ 下反应8h。回收苯酚后，用稀盐酸进行酸化。用乙醚提取，用水洗。干燥后蒸馏，收集145～ 152 ℃ (800Pa)馏分，得产品 60g ，收率64%，m. p. 83～ 84 ℃ (文献值m. p. 85～ 86 ℃ )。

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对苯氧基苯酚海关

[ 海关编码 ]: 2909500000

[ 中文概述 ]:
2909500000. 醚酚、醚醇酚及其卤化、磺化、硝化或亚硝化衍生物. 增值税率:17.0%. 退税率:9.0%. 监管条件:无. 最惠国关税:5.5%. 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2909500000 ether-phenols, ether-alcohol-phenols and their halogenated, sulphonated, nitrated or nitrosated derivatives VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:5.5% General tariff:30.0%

对苯氧基苯酚文献

Cellular apoptosis and cytotoxicity of phenolic compounds: a quantitative structure-activity relationship study.

J. Med. Chem. 48 , 7234-42, (2005)

In this comprehensive study on the caspase-mediated apoptosis-inducing effect of 51 substituted phenols in a murine leukemia cell line (L1210), we determined the concentrations needed to induce caspas...

Activation and inhibition of leukotriene A4 hydrolase aminopeptidase activity by diphenyl ether and derivatives.

Bioorg. Med. Chem. Lett. 18 , 6549-52, (2008)

The synthesis and biological evaluation of a series of diphenyl ether derivatives were described. The compounds can either activate or inhibit the aminopeptidase activity of leukotriene A(4) hydrolase...

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