去乙基胺碘酮

去乙基胺碘酮用途

Desethylamiodarone (N-Deethylamiodarone) 是抗心律失常化合物胺碘酮 (Amiodarone (HY-14187)) 的主要代谢物。Desethylamiodarone 具有抗心律失常活性。Desethylamiodarone 还可诱导癌细胞凋亡 (apoptosis)。

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去乙基胺碘酮名称

[ CAS 号 ]:
83409-32-9

[ 中文名 ]:
去乙基胺碘酮

[ 英文名 ]:
Desethylamiodarone

[中文别名 ]:

[英文别名 ]:

N-Desethylamiodarone
Desethylamiodarone
N-Deethylamiodarone
N-Monodesethylamiodarone
Deethylamiodarone
Amiodarone Impurity 2

去乙基胺碘酮生物活性

[ 描述 ]:

[ 相关类别 ]:

信号通路 >> 细胞凋亡 >> 细胞凋亡

研究领域 >> 癌症

[参考文献]

[1]. Bognar Z, et al. Desethylamiodarone-A metabolite of amiodarone-Induces apoptosis on T24 human bladder cancer cells via multiple pathways. PLoS One. 2017 Dec 8;12(12):e0189470.

[2]. Kannan R, et al. Amiodarone toxicity. II. Desethylamiodarone-induced phospholipidosis and ultrastructural changes during repeated administration in rats. Fundam Appl Toxicol. 1991 Jan;16(1):103-9.

去乙基胺碘酮物理化学性质

[ 密度 ]:
1.638 g/cm3

[ 沸点 ]:
630.3ºC at 760 mmHg

[ 分子式 ]:
C₂₃H₂₅I₂NO₃

[ 分子量 ]:
617.25800

[ 闪点 ]:
335ºC

[ 精确质量 ]:
616.99200

[ PSA ]:
51.47000

[ LogP ]:
6.59480

[ 折射率 ]:
1.635

去乙基胺碘酮毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: PC4939000

CHEMICAL NAME :: Methanone, (2-butyl-3-benzofuranyl)(4-(2-(ethylamino)ethoxy)-3,5 -diiodophenyl)-

CAS REGISTRY NUMBER :: 83409-32-9

LAST UPDATED :: 199312

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C23-H25-I2-N-O3

MOLECULAR WEIGHT :: 617.29

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1380 mg/kg/23D-I

TOXIC EFFECTS :: Lungs, Thorax, or Respiration - other changes Nutritional and Gross Metabolic - weight loss or decreased weight gain Nutritional and Gross Metabolic - changes in phosphorus

REFERENCE :: FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1981- Volume(issue)/page/year: 16,103,1991