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GAB氧杂DOL盐酸盐

GAB氧杂DOL盐酸盐用途

Gaboxadol hydrochloride (Lu 02-030 hydrochloride) 是含有 α4-δ 亚基的 GABAA 受体的选择性激动剂,产生抗焦虑和镇静作用。

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GAB氧杂DOL盐酸盐名称

[ CAS 号 ]:
85118-33-8

[ 中文名 ]:
加波沙朵盐酸盐

[ 英文名 ]:
Gaboxadol hydrochloride

[中文别名 ]:

[英文别名 ]:

Gaboxadol hydrochloride

GAB氧杂DOL盐酸盐生物活性

[ 描述 ]:

Gaboxadol hydrochloride (Lu 02-030 hydrochloride) 是含有 α4-δ 亚基的 GABAA 受体的选择性激动剂,产生抗焦虑和镇静作用。

[ 相关类别 ]:

信号通路 >> 跨膜转运 >> GABA受体

研究领域 >> 神经疾病

信号通路 >> 神经信号通路 >> GABA受体

[ 靶点 ]

GABAA[1]

[参考文献]

[1]. Zanettini C, et al. Comparing the discriminative stimulus effects of modulators of GABAA receptors containing α4-δ subunits with those of gaboxadol in rats. Psychopharmacology (Berl). 2016 May;233(10):2005-13.

GAB氧杂DOL盐酸盐物理化学性质

[ 沸点 ]:
295.7ºC at 760 mmHg

[ 熔点 ]:
236 °C

[ 分子式 ]:
C₆H₉ClN₂O₂

[ 分子量 ]:
176.601

[ 闪点 ]:
132.6ºC

[ 精确质量 ]:
176.035248

[ PSA ]:
58.03000

[ LogP ]:
0.74440

[ 外观性状 ]:
固体;White to Almost white powder to crystal

[ 储存条件 ]:
室温，干燥

GAB氧杂DOL盐酸盐MSDS

详细MSDS(安全技术说明书)

GAB氧杂DOL盐酸盐安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 安全声明 (欧洲) ]:
22-24/25

[ 危险品运输编码 ]:
NONH for all modes of transport

[ RTECS号 ]:
NY3396800

GAB氧杂DOL盐酸盐文献

Molecular and functional diversity of GABA-A receptors in the enteric nervous system of the mouse colon.

J. Neurosci. 34(31) , 10361-78, (2014)

The enteric nervous system (ENS) provides the intrinsic neural control of the gastrointestinal tract (GIT) and regulates virtually all GI functions. Altered neuronal activity within the ENS underlies ...

Effect of nucleus accumbens shell infusions of ganaxolone or gaboxadol on ethanol consumption in mice.

Psychopharmacol. Ser. 232(8) , 1415-26, (2015)

Allopregnanolone (ALLO) is an endogenous neuroactive steroid thought to alter the reinforcement value of alcohol (ethanol) due to its actions as a positive modulator of the GABAA receptor (GABAAR). Ex...

Effects of gaboxadol on the expression of cocaine sensitization in rats.

Exp. Clin. Psychopharmacol. 24 , 131-41, (2016)

Behavioral sensitization to psychostimulants is associated with changes in dopamine (DA), glutamate, and GABA within the mesocorticolimbic and nigrostriatal DA systems. Because GABAA receptors are hig...

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