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红花黄色素(A)

红花黄色素(A)用途

Safflor yellow A 是一种从红花中提取的黄酮,是 Safflor yellow 的水溶性单体。Safflor yellow A 通过抑制细胞氧化应激和凋亡保护大鼠心肌细胞免于缺氧/复氧 (A/R) 损伤。

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红花黄色素(A)名称

[ CAS 号 ]:
85532-77-0

[ 中文名 ]:
红花黄色素(A)

[ 英文名 ]:
Safflor yellow A

[中文别名 ]:

红花黄色素A

红花黄色素(A)生物活性

[ 描述 ]:

[ 相关类别 ]:

信号通路 >> 细胞凋亡 >> 细胞凋亡

研究领域 >> 心血管疾病

研究领域 >> 炎症/免疫

[体内研究]

红花黄色素A(40、60和80nm)浓度依赖性地阻断A/R诱导的1-3d龄Sprague-Dawley大鼠心肌细胞变化[1]。

[参考文献]

[1]. Duan JL, et al. Safflor yellow A protects neonatal rat cardiomyocytes against anoxia/reoxygenation injury in vitro. Acta Pharmacol Sin. 2013 Apr;34(4):487-95.

红花黄色素(A)物理化学性质

[ 密度 ]:
1.81g/cm3

[ 沸点 ]:
942.3ºC at 760 mmHg

[ 分子式 ]:
C₂₇H₃₀O₁₅

[ 分子量 ]:
610.51700

[ 闪点 ]:
313ºC

[ 精确质量 ]:
610.15300

[ PSA ]:
273.36000

[ 折射率 ]:
1.764

红花黄色素(A)毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: UQ0333750

CHEMICAL NAME :: 9H-Pyrano(3,2-b)benzofuran-9-one, 2,3,4,4a,6,9b-hexahydro-6-beta-D-glucopyranosyl-2- (hydroxymethyl)-8-(3-(4-hydroxyphenyl)-1-oxo-2-propen yl)-3,4,6,7-tetrahydr oxy-

CAS REGISTRY NUMBER :: 85532-77-0

LAST UPDATED :: 199612

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C27-H30-O15

MOLECULAR WEIGHT :: 594.57

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 5530 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Behavioral - ataxia Lungs, Thorax, or Respiration - dyspnea

REFERENCE :: CTYAD8 Zhongcaoyao. Chinese Traditional and Herbal Medicine. (China International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) V.11- 1980- Volume(issue)/page/year: 15,348,1984

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 5490 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Behavioral - ataxia Lungs, Thorax, or Respiration - respiratory stimulation

REFERENCE :: CTYAD8 Zhongcaoyao. Chinese Traditional and Herbal Medicine. (China International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) V.11- 1980- Volume(issue)/page/year: 15,348,1984