安妥

安妥用途

【用途一】
硫脲类急性杀鼠剂。选择性强，主要用于防治褐家鼠及黄毛鼠，对其他鼠种毒性较低。该药剂有强胃毒作用，也可损害鼠类呼吸系统。一般食后6～72h内死亡。安妥适口性好，初次使用效果理想，但摄入亚致死剂量后会产生很强的耐药性，耐药能力可提高7～50倍，并对其他硫脲衍生物产生交互抗性。安妥以配制毒饵来防治鼠类，毒饵有效成分为0.5%～2%，配制方法同磷化锌杀鼠剂。例1，0.5%安妥胡萝卜毒饵（或用水果、蔬菜代替），每房间放2～3堆，每堆毒饵量10～20g,3d后回收剩余毒饵。例2，安妥原粉1份、鱼骨粉1份、食用油1份、玉米面97份，混合均匀后加适量水和成面团，并制成黄豆粒大小毒饵丸，每房间放量2～3堆，每堆10～20g，防治褐家鼠效果甚好。也可制成2%安妥小麦毒饵应用。
【用途二】
作灭鼠药。

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安妥名称

[ CAS 号 ]:
86-88-4

[ 中文名 ]:
安妥

[ 英文名 ]:
Naphtox

[中文别名 ]:

[英文别名 ]:

Rattrack
1-naphthalenylthiourea
1-(1-naphthyl)thiourea
Alrato
1-naphthylthiourea
Dirax
Thiourea,1-naphthalenyl
N-naphthyl-thiourea
ANTU
EINECS 201-706-3

安妥物理化学性质

[ 密度 ]:
1.333 g/cm3

[ 沸点 ]:
377.6ºC at 760 mmHg

[ 熔点 ]:
193 °C

[ 分子式 ]:
C₁₁H₁₀N₂S

[ 分子量 ]:
202.27500

[ 闪点 ]:
182.1ºC

[ 精确质量 ]:
202.05600

[ PSA ]:
70.14000

[ LogP ]:
3.26860

[ 外观性状 ]:
白色,无臭结晶粉末

[ 折射率 ]:
1.794

[ 储存条件 ]:
库房通风低温干燥,与食品原料分开储运

安妥MSDS

详细MSDS(安全技术说明书)

安妥毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: YT9275000

CHEMICAL NAME :: Urea, 1-(1-naphthyl)-2-thio-

CAS REGISTRY NUMBER :: 86-88-4

BEILSTEIN REFERENCE NO. :: 0778118

LAST UPDATED :: 199712

DATA ITEMS CITED :: 52

MOLECULAR FORMULA :: C11-H10-N2-S

MOLECULAR WEIGHT :: 202.29

WISWESSER LINE NOTATION :: L66J BMYZUS

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Human - man

DOSE/DURATION :: 588 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 6 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 2470 ug/kg

TOXIC EFFECTS :: Lungs, Thorax, or Respiration - acute pulmonary edema Lungs, Thorax, or Respiration - pleural effusion

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 5 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 10 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 380 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 16 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Primate - monkey

DOSE/DURATION :: 4250 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Primate - monkey

DOSE/DURATION :: 175 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Primate - monkey

DOSE/DURATION :: >2 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - cat

DOSE/DURATION :: 500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: >200 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - pig

DOSE/DURATION :: 50 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 350 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Bird - chicken

DOSE/DURATION :: 4250 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Bird - chicken

DOSE/DURATION :: 2500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Bird - chicken

DOSE/DURATION :: 700 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 5 mg/kg

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Lungs, Thorax, or Respiration - tumors Blood - tumors

MUTATION DATA

TYPE OF TEST :: Morphological transformation

TEST SYSTEM :: Rodent - hamster Embryo

REFERENCE :: NCIMAV National Cancer Institute, Monograph. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) No.1- 1959- Volume(issue)/page/year: 58,243,1981 *** REVIEWS *** ACGIH TLV-Not classifiable as a human carcinogen DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 ACGIH TLV-TWA 0.3 mg/m3 DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 IARC Cancer Review:Animal Inadequate Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 30,347,1983 IARC Cancer Review:Human Inadequate Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 30,347,1983 IARC Cancer Review:Group 3 IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979- Volume(issue)/page/year: 7,263,1987 TOXICOLOGY REVIEW ADCSAJ Advances in Chemistry Series. (American Chemical Soc., Distribution Office Dept. 223, POB 57136, West End Stn., Washington, DC 20037) No.1- 1950- Volume(issue)/page/year: 13,271,1970 *** U.S. STANDARDS AND REGULATIONS *** MSHA STANDARD-air:TWA 0.3 mg/m3 DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: 3,14,1971 OSHA PEL (Gen Indu):8H TWA 0.3 mg/m3 CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1910.1000,1994 OSHA PEL (Construc):8H TWA 0.3 mg/m3 CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1926.55,1994 OSHA PEL (Shipyard):8H TWA 0.3 mg/m3 CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1915.1000,1993 OSHA PEL (Fed Cont):8H TWA 0.3 mg/m3 CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 41,50-204.50,1994 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-AUSTRALIA:TWA 0.3 mg/m3 JAN 1993 OEL-AUSTRIA:TWA 0.3 mg/m3 JAN 1993 OEL-BELGIUM:TWA 0.3 mg/m3 JAN 1993 OEL-DENMARK:TWA 0.3 mg/m3;Carcinogen JAN 1993 OEL-FINLAND:TWA 0.3 mg/m3;STEL 0.9 mg/m3 JAN 1993 OEL-FRANCE:TWA 0.3 mg/m3 JAN 1993 OEL-GERMANY:TWA 0.3 mg/m3 JAN 1993 OEL-THE NETHERLANDS:TWA 0.3 mg/m3 JAN 1993 OEL-THE PHILIPPINES:TWA 0.3 mg/m3 JAN 1993 OEL-SWITZERLAND:TWA 0.3 mg/m3;STEL 1.5 mg/m3 JAN 1993 OEL-TURKEY:TWA 0.3 mg/m3 JAN 1993 OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH RECOMMENDED EXPOSURE LEVEL (REL) : NIOSH REL TO ANTU-air:10H TWA 0.3 mg/m3 REFERENCE : NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda. Volume(issue)/page/year: DHHS #92-100,1992 NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - M0294 No. of Facilities: 25 (estimated) No. of Industries: 1 No. of Occupations: 4 No. of Employees: 1450 (estimated)

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安妥安全信息

[ 符号 ]:

GHS06, GHS08

[ 信号词 ]:
Danger

[ 危害声明 ]:
H300-H351

[ 警示性声明 ]:
P301 + P310 + P330

[ 个人防护装备 ]:
Eyeshields;Faceshields;Gloves;type P2 (EN 143) respirator cartridges

[ 危害码 (欧洲) ]:
T+

[ 风险声明 (欧洲) ]:
28-40

[ 安全声明 (欧洲) ]:
S28-S36/37-S45-S25-S23

[ 危险品运输编码 ]:
1651

[ RTECS号 ]:
YT9275000

[ 包装等级 ]:
I

[ 危险类别 ]:
6.1

[ 海关编码 ]:
2930909059

安妥合成路线

详细合成路线

安妥上下游产品

安妥上游产品

安妥下游产品

安妥制备

1.α萘胺与硫氰酸铵反应制得安妥。
2.制备方法二

3.制备方法三

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安妥海关

[ 海关编码 ]: 2930909059

[ 中文概述 ]:
2930909059 烯草酮、磺草酮、嗪草酸甲酯、磺草酮等〔包括苯氟磺胺、甲磺乐灵、氯硫酰草胺、脱叶磷〕。监管条件:S(进出口农药登记证明)。增值税率:17.0%。退税率:9.0%。最低关税:6.5%。普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ 监管条件 ]: S.进出口农药登记证明

[ Summary ]:
HS:2930909059 hydrazinecarbothioamide VAT:17.0% Tax rebate rate:9.0% Supervision conditions:S MFN tariff:6.5% General tariff:30.0%

安妥文献

Effects of peripheral benzodiazepine receptor ligand Ro5-4864 in four animal models of acute lung injury.

J. Surg. Res. 182(2) , 277-84, (2013)

Acute lung injury (ALI) is a syndrome of inflammation and increased permeability of the blood-gas barrier. It is associated with high morbidity and mortality. Despite intensive research, treatments re...

Fluorescein-labeled dextran concentration is increased in BAL fluid after ANTU-induced edema in rats.

J. Appl. Physiol. 85(3) , 842-8, (1998)

Several methodologies have been developed to assess alveolocapillary membrane permeability in acute lung injury. The purpose of this study was to determine the reliability of FITC-dextran compared wit...

Acute effect of endothelin-1 on lung oedema induced by alpha-naphthylthiourea (ANTU).

Pharmacol. Res. 33(6) , 375-8, (1996)

Alpha-naphthylthiourea when injected intraperitoneally to rats (10 mg kg-1 i.p.) produced lung oedema as indicated by an increase in lung weight/body ratio and pleural effusion reaching a maximum with...

更多文献

安妥

安妥用途

安妥名称

安妥物理化学性质

安妥MSDS

详细MSDS(安全技术说明书)

安妥毒性和生态

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

安妥安全信息

安妥合成路线

详细合成路线

安妥上下游产品

安妥上游产品

安妥下游产品

安妥制备

安妥海关

安妥文献

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