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5-溴靛红

5-溴靛红用途

用于生化研究与有机合成.

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5-溴靛红名称

[ CAS 号 ]:
87-48-9

[ 中文名 ]:
5-溴靛红

[ 英文名 ]:
5-Bromoisatin

[中文别名 ]:

[英文别名 ]:

5-monobromoisatin
MFCD00005719
INDOLE-2,3-DIONE,5-BROMO
5-bromo-1,3-dihydro-indol-2-one
5-Bromoindole-2,3-dione
5-Bromisatin [Czech]
1H-Indole-2,3-dione, 5-bromo-
Isatin,5-bromo
1H-Indole-2,3-dione,5-bromo
5-Bromo-1H-indole-2,3-dione

5-溴靛红物理化学性质

[ 密度 ]:
1.8±0.1 g/cm3

[ 沸点 ]:
136ºC

[ 熔点 ]:
247-252 °C(lit.)

[ 分子式 ]:
C₈H₄BrNO₂

[ 分子量 ]:
226.027

[ 精确质量 ]:
224.942535

[ PSA ]:
46.17000

[ LogP ]:
1.33

[ 外观性状 ]:
红色晶体

[ 折射率 ]:
1.650

[ 储存条件 ]:
库房通风低温干燥

[ 水溶解性 ]:
可溶于：二甲基甲酰胺

5-溴靛红MSDS

5-溴靛红毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: NL7875000

CHEMICAL NAME :: Indole-2,3-dione, 5-bromo-

CAS REGISTRY NUMBER :: 87-48-9

BEILSTEIN REFERENCE NO. :: 0383760

LAST UPDATED :: 199709

DATA ITEMS CITED :: 5

MOLECULAR FORMULA :: C8-H4-Br-N-O2

MOLECULAR WEIGHT :: 226.04

WISWESSER LINE NOTATION :: T56 BMVVJ GE

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration into the eye

SPECIES OBSERVED :: Rodent - rabbit

REFERENCE :: 85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year: -,821,1986 ** ACUTE TOXICITY DATA **

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 680 mg/kg

TOXIC EFFECTS :: Behavioral - excitement Behavioral - muscle contraction or spasticity Lungs, Thorax, or Respiration - other changes

REFERENCE :: GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 53(2),93,1988

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 3430 mg/kg

TOXIC EFFECTS :: Behavioral - excitement Behavioral - muscle contraction or spasticity Lungs, Thorax, or Respiration - other changes

REFERENCE :: GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 53(2),93,1988

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 437 mg/kg

TOXIC EFFECTS :: Lungs, Thorax, or Respiration - respiratory stimulation

REFERENCE :: PCJOAU Pharmaceutical Chemistry Journal (English Translation). Translation of KHFZAN. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) No.1- 1967- Volume(issue)/page/year: 15,858,1981 ** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 45 gm/kg/30D-I

TOXIC EFFECTS :: Liver - liver function tests impaired Nutritional and Gross Metabolic - weight loss or decreased weight gain Related to Chronic Data - death

REFERENCE :: GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 53(2),93,1988

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5-溴靛红安全信息

[ 符号 ]:

GHS05, GHS07

[ 信号词 ]:
Danger

[ 危害声明 ]:
H315-H318-H335

[ 警示性声明 ]:
P261-P280-P305 + P351 + P338

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xi:Irritant;

[ 风险声明 (欧洲) ]:
R37/38;R41

[ 安全声明 (欧洲) ]:
S26-S36/39-S37/39

[ 危险品运输编码 ]:
2811

[ WGK德国 ]:
2

[ RTECS号 ]:
NL7875000

[ 海关编码 ]:
2933990090

5-溴靛红合成路线

5-溴靛红上下游产品

5-溴靛红上游产品

5-溴靛红下游产品

5-溴靛红海关

[ 海关编码 ]: 2933990090

[ 中文概述 ]:
2933990090. 其他仅含氮杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

5-溴靛红文献

Mass spectrometry imaging reveals new biological roles for choline esters and Tyrian purple precursors in muricid molluscs.

Sci. Rep. 5 , 13408, (2015)

Despite significant advances in chemical ecology, the biodistribution, temporal changes and ecological function of most marine secondary metabolites remain unknown. One such example is the association...

Selective inhibition of carboxylesterases by isatins, indole-2,3-diones.

J. Med. Chem. 50 , 1876-85, (2007)

Carboxylesterases (CE) are ubiquitous enzymes thought to be responsible for the metabolism and detoxification of xenobiotics. Numerous clinically used drugs including Demerol, lidocaine, capecitabine,...

In vitro cytotoxicity evaluation of some substituted isatin derivatives.

Bioorg. Med. Chem. 15 , 931-8, (2007)

A range of substituted 1H-indole-2,3-diones (isatins) were synthesized using standard procedures and their cytotoxicity evaluated against the human monocyte-like histiocytic lymphoma (U937) cell line ...

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