对溴苯胺
对溴苯胺用途
用于偶氮染料制造及有机合成
【用途二】
有机合成中间体。
【用途三】
4-溴苯胺(106-40-1)用于制造染料原料,如偶氮染料、喹啉染料等,医药及有机合成中间体。
【用途四】
有机合成,制备二氢喹唑啉。
对溴苯胺名称
[ CAS 号 ]:
106-40-1
[ 中文名 ]:
4-溴苯胺
[ 英文名 ]:
4-Bromoaniline
[中文别名 ]:
[英文别名 ]:
- para bromo aniline
- para-bromoaniline
- Benzenamine,4-bromo
- 4-bromo-aniline
- 4-bromobenzenamide
- 4-Bromoaniline
- EINECS 203-393-9
- 4-Bromobenzenamine
- ZR DE
- MFCD00007822
对溴苯胺物理化学性质
[ 密度 ]:
1.6±0.1 g/cm3
[ 沸点 ]:
225.9±13.0 °C at 760 mmHg
[ 熔点 ]:
56-62 °C(lit.)
[ 分子式 ]:
C6H6BrN
[ 分子量 ]:
172.023
[ 闪点 ]:
90.4±19.8 °C
[ 精确质量 ]:
170.968353
[ PSA ]:
26.02000
[ LogP ]:
2.05
[ 外观性状 ]:
结晶
[ 蒸汽压 ]:
0.1±0.4 mmHg at 25°C
[ 折射率 ]:
1.626
[ 储存条件 ]:
库房通风低温干燥,与氧化剂、酸类、食品添加剂分开存放
[ 稳定性 ]:
Stable. Combustible. Incompatible with strong oxidizing agents, peroxides, acids, acid chlorides, acid anhydrides, chloroformates. May be air sensitive.
[ 水溶解性 ]:
<0.1 g/100 mL at 23 ºC
对溴苯胺MSDS
对溴苯胺毒性和生态
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- BW9280000
- CHEMICAL NAME :
- Aniline, p-bromo-
- CAS REGISTRY NUMBER :
- 106-40-1
- BEILSTEIN REFERENCE NO. :
- 0742031
- LAST UPDATED :
- 199710
- DATA ITEMS CITED :
- 11
- MOLECULAR FORMULA :
- C6-H6-Br-N
- MOLECULAR WEIGHT :
- 172.04
- WISWESSER LINE NOTATION :
- ZR DE
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 456 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 289 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 248 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
MUTATION DATA
- TYPE OF TEST :
- Unscheduled DNA synthesis
- TEST SYSTEM :
- Rodent - rat Liver
- DOSE/DURATION :
- 50 umol/L
- REFERENCE :
- ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For publisher information, see EMMUEG. Volume(issue)/page/year: 3,11,1981 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - M2753 No. of Facilities: 174 (estimated) No. of Industries: 1 No. of Occupations: 2 No. of Employees: 1744 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - M2753 No. of Facilities: 184 (estimated) No. of Industries: 3 No. of Occupations: 6 No. of Employees: 4703 (estimated) No. of Female Employees: 3745 (estimated)
对溴苯胺安全信息
[ 符号 ]:
GHS06
[ 信号词 ]:
Danger
[ 危害声明 ]:
H302-H311-H315-H319-H335
[ 警示性声明 ]:
P261-P280-P305 + P351 + P338-P312
[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Faceshields;Gloves
[ 危害码 (欧洲) ]:
Xn:Harmful
[ 风险声明 (欧洲) ]:
R20/21/22;R36/37/38
[ 安全声明 (欧洲) ]:
S26-S36/37-S36/37/39
[ 危险品运输编码 ]:
UN 2811 6.1/PG 3
[ WGK德国 ]:
3
[ RTECS号 ]:
BW9280000
[ 包装等级 ]:
III
[ 危险类别 ]:
6.1
[ 海关编码 ]:
29214210
对溴苯胺合成路线
对溴苯胺上下游产品
对溴苯胺上游产品
对溴苯胺下游产品
对溴苯胺制备
以对硝基苯胺为原料,经重氮化、溴代得到对溴硝基苯,然后用铁粉还原得到。
对溴苯胺海关
[ 海关编码 ]: 2921420090
[ 中文概述 ]:
2921420090 其他苯胺衍生物及其盐. 增值税率:17.0% 退税率:9.0% 监管条件:无 最惠国关税:6.5% 普通关税:30.0%
[ 申报要素 ]: 品名, 成分含量, 用途
[ Summary ]:
HS:2921420090 aniline derivatives and their salts VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%
对溴苯胺文献
J. Environ Biol. 36 , 909-18, (2015)
Eighteen novel 5-phenyl-3-(substitutedthioxoquinazolinonyl) isoxazoles (5a-r) were synthesized by cycloaddition of various chalcones with hydroxylaminehydrochloride (NH2OH.HCl). All the newly synthesi...
Biopartitioning micellar chromatography to predict mutagenicity of aromatic amines.Eur. J. Med. Chem. 42 , 1396-402, (2007)
Mutagenicity is a toxicity endpoint associated with the chronic exposure to chemicals. Aromatic amines have considerable industrial and environmental importance due to their widespread use in industry...
Acute metobromuron poisoning with severe associated methemoglobinemia. Identification of four metabolites in plasma and urine by LC-DAD, LC-ESI-MS, and LC-ESI-MS-MS.J. Anal. Toxicol. 24(3) , 157-64, (2000)
A case of self poisoning with metobromuron, a urea derivative used as a herbicide, is reported. Severe methemoglobinemia observed at the admission (80%) disappeared only at day 11, and hemolysis appea...
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相关化合物
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