荜茇环碱

荜茇环碱用途

Pipernonaline 是胡椒碱衍生物,具有抗前列腺癌活性。Pipernonaline 抑制雄激素依赖/非依赖性 LNCaP/PC-3 前列腺细胞的增殖。Pipernonaline 激活 caspase-3,促进 procaspase-3/PARP 裂解。Pipernonaline 还介导活性氧 (ROS) 产生、胞内 Ca(2+) 增加和线粒体膜去极化。

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荜茇环碱名称

[ CAS 号 ]:
88660-10-0

[ 中文名 ]:
荜茇环碱

[ 英文名 ]:
Pipernonaline

[英文别名 ]:

荜茇环碱生物活性

[ 描述 ]:

[ 相关类别 ]:

信号通路 >> 细胞凋亡 >> 细胞凋亡

研究领域 >> 癌症

信号通路 >> 细胞凋亡 >> 胱天蛋白酶

[参考文献]

[1]. Lee W, et al. Pipernonaline from Piper longum Linn. induces ROS-mediated apoptosis in human prostate cancer PC-3 cells. Biochem Biophys Res Commun. 2013 Jan 4;430(1):406-12..

荜茇环碱物理化学性质

[ 分子式 ]:
C₂₁H₂₇NO₃

[ 分子量 ]:
341.44400

[ 精确质量 ]:
341.19900

[ PSA ]:
38.77000

[ LogP ]:
4.49550

荜茇环碱MSDS

详细MSDS(安全技术说明书)

荜茇环碱安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H302-H413

[ 危险品运输编码 ]:
NONH for all modes of transport

荜茇环碱文献

Antihyperlipidemic compounds from the fruit of Piper longum L.

Phytother Res. 23(8) , 1194-6, (2009)

A bioassay-guided isolation of an ethanol extract of the fruit of Piper longum L. yielded piperlonguminine, piperine and pipernonaline, as the main antihyperlipidemic constituents. They exhibit apprec...

Alkamides from the fruits ofPiper longumandPiper nigrumdisplaying potent cell adhesion inhibition

Bioorg. Med. Chem. Lett. 18 , 4544-6, (2008)

Eight alkamides 1– 8 were isolated from EtOH extracts of the fruits of Piper longum and nigrum. Among the tested alkamide derivatives 1– 8, dehydropipernonaline (8) showed the most inhibition of the d...

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